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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi495MagnesiumUniRule annotation1
Metal bindingi501MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciPMAR59922:G1G80-553-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:P9303_06021
OrganismiProchlorococcus marinus (strain MIT 9303)
Taxonomic identifieri59922 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002274 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003297671 – 721Polyribonucleotide nucleotidyltransferaseAdd BLAST721

Proteomic databases

PRIDEiA2C794

Structurei

3D structure databases

ProteinModelPortaliA2C794
SMRiA2C794
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini562 – 621KHUniRule annotationAdd BLAST60
Domaini631 – 699S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

A2C794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGQTQSISF DGREIRLTTG RYAPQAGGSV MMECGDTSVL VTATRSTGRE
60 70 80 90 100
GIDFLPLICD YEERLYAAGR IPGSFMRREG RPPERATLIA RLIDRPMRPL
110 120 130 140 150
FPSWMRDDLQ IVATCLSLDE RVPADVLAVT GASMATLLAG IPFQGPMAAV
160 170 180 190 200
RVGLLGDDFV LNPSYREIER GDLDLVVAGT PDGVVMVEAG ANQLPEGDVI
210 220 230 240 250
EAIDFGYEAV CELIKAQQSI LKDAGIKQVQ PEPPTQDTKL STYLEKNCSK
260 270 280 290 300
SIGEVLKQFE QTKAERDSKL DAIKAKTAEA IDSLKEDDAV RKSVNANSKV
310 320 330 340 350
LSNNFKALTK KLMREQIIKQ GKRVDGRKLD EVRTITSAAG VLPKRVHGSG
360 370 380 390 400
LFQRGLTQVL STATLGTPSD AQEMDDLNPG PEKTYLHHYN FPPYSVGETR
410 420 430 440 450
PMRSPGRREV GHGSLAERAI IPVLPPKDTF PYVLRVVSEV LSSNGSTSMG
460 470 480 490 500
SVCGSTLALM DAGVPLKAPV SGAAMGLIKE DAEIRILTDI QGIEDFLGDM
510 520 530 540 550
DFKVAGTKDG ITALQMDMKI TGLPVKTIAE AVNQARPARI HILEKMLEAI
560 570 580 590 600
DAPRTSLSPH APRLLSFRID PELIGTVIGP GGRTIKGITE RTNTKIDIED
610 620 630 640 650
GGIVTIASHD GAAAEAAQRI IEGLTRKVNE GEVFSGTITR IIPIGAFVEI
660 670 680 690 700
LPGKEGMIHI SQLSEARVEK VDDVVKVGDE VTVRIREIDN RGRINLTLRG
710 720
VPQNGEETQS EPAPTPVAPL N
Length:721
Mass (Da):77,898
Last modified:February 20, 2007 - v1
Checksum:i848AE2F244C8E85B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000554 Genomic DNA Translation: ABM77354.1

Genome annotation databases

EnsemblBacteriaiABM77354; ABM77354; P9303_06021
KEGGipmf:P9303_06021

Similar proteinsi

Entry informationi

Entry nameiPNP_PROM3
AccessioniPrimary (citable) accession number: A2C794
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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