A2C745 (LPXB_PROM3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	P9303_05531

Organism

Prochlorococcus marinus (strain MIT 9303) [Complete proteome] [HAMAP]

Taxonomic identifier

59922 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Lipid-A-disaccharide synthase HAMAP MF_00392		PRO_1000049406

Sequences

	Sequence		Length	Mass (Da)
	A2C745 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 30F2DD5364FBC44A	FASTA	392	43,485
	10 20 30 40 50 60 MVRLLISTGE VSGDLQGSLL IQALQREVER RSLPLELMAL GGPRMQASGA ELLADTAPMG 70 80 90 100 110 120 AIGLWEALPL VLPTLRLQSR VDHVLKQRPP DAVVLIDYMG ANVRLGHKLR RWFPRVPIIY 130 140 150 160 170 180 YIAPQEWAWR FGDGGTTQLL SFTDRILAIF PVEAEFYAQR GAKVTWVGHP LLDTVSVLPD 190 200 210 220 230 240 RQLARERLGL KSGQRLLLLL PASRQQELRY LMPTLAKAAA LLQQRDPSLE VIVPAGLASF 250 260 270 280 290 300 ETSLQKALEA AAVRGRVLSA QQADELKPML YAAADLALGK SGTVNMELAL RGVPQVVGYK 310 320 330 340 350 360 VSRITAFVAR HFLRFRVDHI SPVNLLLKER LVPELLQDEF TAEALVQAAI PLLEDPAQRH 370 380 390 EMLEGYWRLR QTLGVPGVTD RAAKEILDLT KP

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MIT 9303.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000554 Genomic DNA. Translation: ABM77305.1.
RefSeq	YP_001016570.1. NC_008820.1.
3D structure databases
ProteinModelPortal	A2C745.
ModBase	Search...
Protein-protein interaction databases
STRING	A2C745.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4778596.
GenomeReviews	Gene locus P9303_05531 in contig CP000554_GR.
KEGG	pmf:P9303_05531.
PATRIC	22998535. VBIProMar17757_0590.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	PDFNLGL.
PhylomeDB	A2C745.
ProtClustDB	PRK00025.
Family and domain databases
HAMAP	MF_00392. LpxB. [Tree]
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_PROM3

Accession

Primary (citable) accession number: A2C745

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 20, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program