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A2C745

- LPXB_PROM3

UniProt

A2C745 - LPXB_PROM3

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciPMAR59922:GH54-613-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:P9303_05531
    OrganismiProchlorococcus marinus (strain MIT 9303)
    Taxonomic identifieri59922 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002274: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Lipid-A-disaccharide synthasePRO_1000049406Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi59922.P9303_05531.

    Structurei

    3D structure databases

    ProteinModelPortaliA2C745.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2C745-1 [UniParc]FASTAAdd to Basket

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    MVRLLISTGE VSGDLQGSLL IQALQREVER RSLPLELMAL GGPRMQASGA    50
    ELLADTAPMG AIGLWEALPL VLPTLRLQSR VDHVLKQRPP DAVVLIDYMG 100
    ANVRLGHKLR RWFPRVPIIY YIAPQEWAWR FGDGGTTQLL SFTDRILAIF 150
    PVEAEFYAQR GAKVTWVGHP LLDTVSVLPD RQLARERLGL KSGQRLLLLL 200
    PASRQQELRY LMPTLAKAAA LLQQRDPSLE VIVPAGLASF ETSLQKALEA 250
    AAVRGRVLSA QQADELKPML YAAADLALGK SGTVNMELAL RGVPQVVGYK 300
    VSRITAFVAR HFLRFRVDHI SPVNLLLKER LVPELLQDEF TAEALVQAAI 350
    PLLEDPAQRH EMLEGYWRLR QTLGVPGVTD RAAKEILDLT KP 392
    Length:392
    Mass (Da):43,485
    Last modified:February 20, 2007 - v1
    Checksum:i30F2DD5364FBC44A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000554 Genomic DNA. Translation: ABM77305.1.
    RefSeqiYP_001016570.1. NC_008820.1.

    Genome annotation databases

    EnsemblBacteriaiABM77305; ABM77305; P9303_05531.
    GeneIDi4778596.
    KEGGipmf:P9303_05531.
    PATRICi22998535. VBIProMar17757_0590.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000554 Genomic DNA. Translation: ABM77305.1 .
    RefSeqi YP_001016570.1. NC_008820.1.

    3D structure databases

    ProteinModelPortali A2C745.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59922.P9303_05531.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM77305 ; ABM77305 ; P9303_05531 .
    GeneIDi 4778596.
    KEGGi pmf:P9303_05531.
    PATRICi 22998535. VBIProMar17757_0590.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci PMAR59922:GH54-613-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9303.

    Entry informationi

    Entry nameiLPXB_PROM3
    AccessioniPrimary (citable) accession number: A2C745
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3