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A2C745

- LPXB_PROM3

UniProt

A2C745 - LPXB_PROM3

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPMAR59922:GH54-613-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:P9303_05531
OrganismiProchlorococcus marinus (strain MIT 9303)
Taxonomic identifieri59922 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002274: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Lipid-A-disaccharide synthasePRO_1000049406Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59922.P9303_05531.

Structurei

3D structure databases

ProteinModelPortaliA2C745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A2C745-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRLLISTGE VSGDLQGSLL IQALQREVER RSLPLELMAL GGPRMQASGA
60 70 80 90 100
ELLADTAPMG AIGLWEALPL VLPTLRLQSR VDHVLKQRPP DAVVLIDYMG
110 120 130 140 150
ANVRLGHKLR RWFPRVPIIY YIAPQEWAWR FGDGGTTQLL SFTDRILAIF
160 170 180 190 200
PVEAEFYAQR GAKVTWVGHP LLDTVSVLPD RQLARERLGL KSGQRLLLLL
210 220 230 240 250
PASRQQELRY LMPTLAKAAA LLQQRDPSLE VIVPAGLASF ETSLQKALEA
260 270 280 290 300
AAVRGRVLSA QQADELKPML YAAADLALGK SGTVNMELAL RGVPQVVGYK
310 320 330 340 350
VSRITAFVAR HFLRFRVDHI SPVNLLLKER LVPELLQDEF TAEALVQAAI
360 370 380 390
PLLEDPAQRH EMLEGYWRLR QTLGVPGVTD RAAKEILDLT KP
Length:392
Mass (Da):43,485
Last modified:February 20, 2007 - v1
Checksum:i30F2DD5364FBC44A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000554 Genomic DNA. Translation: ABM77305.1.
RefSeqiWP_011825227.1. NC_008820.1.
YP_001016570.1. NC_008820.1.

Genome annotation databases

EnsemblBacteriaiABM77305; ABM77305; P9303_05531.
GeneIDi4778596.
KEGGipmf:P9303_05531.
PATRICi22998535. VBIProMar17757_0590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000554 Genomic DNA. Translation: ABM77305.1 .
RefSeqi WP_011825227.1. NC_008820.1.
YP_001016570.1. NC_008820.1.

3D structure databases

ProteinModelPortali A2C745.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59922.P9303_05531.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM77305 ; ABM77305 ; P9303_05531 .
GeneIDi 4778596.
KEGGi pmf:P9303_05531.
PATRICi 22998535. VBIProMar17757_0590.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PMAR59922:GH54-613-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9303.

Entry informationi

Entry nameiLPXB_PROM3
AccessioniPrimary (citable) accession number: A2C745
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3