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Protein

Ribonuclease Z

Gene

rnz

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Zinc 1; catalyticUniRule annotation1
Metal bindingi64Zinc 1; catalyticUniRule annotation1
Active sitei66Proton acceptorUniRule annotation1
Metal bindingi66Zinc 2; catalyticUniRule annotation1
Metal bindingi67Zinc 2; catalyticUniRule annotation1
Metal bindingi144Zinc 1; catalyticUniRule annotation1
Metal bindingi215Zinc 1; catalyticUniRule annotation1
Metal bindingi215Zinc 2; catalyticUniRule annotation1
Metal bindingi273Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciPMAR59922:G1G80-491-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:P9303_05331
OrganismiProchlorococcus marinus (strain MIT 9303)
Taxonomic identifieri59922 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002274 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000703161 – 318Ribonuclease ZAdd BLAST318

Proteomic databases

PRIDEiA2C725

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA2C725
SMRiA2C725
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000272419
KOiK00784
OMAiGTQRQMM
OrthoDBiPOG091H07TH

Family and domain databases

CDDicd07717 RNaseZ_ZiPD-like_MBL-fold, 1 hit
Gene3Di3.60.15.10, 1 hit
HAMAPiMF_01818 RNase_Z_BN, 1 hit
InterProiView protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR013471 RNase_Z/BN
PfamiView protein in Pfam
PF12706 Lactamase_B_2, 2 hits
SUPFAMiSSF56281 SSF56281, 1 hit
TIGRFAMsiTIGR02651 RNase_Z, 1 hit

Sequencei

Sequence statusi: Complete.

A2C725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVTFLGTSS GVPTRARNVS AVALRLPQRA ELWLFDCGEG TQHQFLRSDL
60 70 80 90 100
RLSQLRRVFV SHMHGDHVFG LPGLLASLGL SGNSNGVDLY GPDPLESYLQ
110 120 130 140 150
GVLRNSSTRI GYPLKVHRVR DAAEQNLIVF EDKDILVRCT PLTHRVPAYA
160 170 180 190 200
YRVEQKPKPG HFNLERAQRL GIPPGPVYAA LKRGEQVSLD DGRVVDGRDF
210 220 230 240 250
CGPDRPGASI VFCTDTVFSE AAVALAAGAD LLIHEATFAH SEAEMAYQKQ
260 270 280 290 300
HSTSTMAAQT AAEAGVGKLV LTHLSPRYAP GNPVTPNDLL REAQAIFSNT
310
ILAKDFLSFE VAPRCNSS
Length:318
Mass (Da):34,612
Last modified:February 20, 2007 - v1
Checksum:i862433E24197E468
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000554 Genomic DNA Translation: ABM77285.1

Genome annotation databases

EnsemblBacteriaiABM77285; ABM77285; P9303_05331
KEGGipmf:P9303_05331

Similar proteinsi

Entry informationi

Entry nameiRNZ_PROM3
AccessioniPrimary (citable) accession number: A2C725
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: February 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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