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Protein

Ribonuclease Z

Gene

rnz

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Zinc 1; catalyticUniRule annotation1
Metal bindingi64Zinc 1; catalyticUniRule annotation1
Active sitei66Proton acceptorUniRule annotation1
Metal bindingi66Zinc 2; catalyticUniRule annotation1
Metal bindingi67Zinc 2; catalyticUniRule annotation1
Metal bindingi144Zinc 1; catalyticUniRule annotation1
Metal bindingi215Zinc 1; catalyticUniRule annotation1
Metal bindingi215Zinc 2; catalyticUniRule annotation1
Metal bindingi273Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:P9303_05331
OrganismiProchlorococcus marinus (strain MIT 9303)
Taxonomic identifieri59922 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002274 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000703161 – 318Ribonuclease ZAdd BLAST318

Proteomic databases

PRIDEiA2C725.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA2C725.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000272419.
KOiK00784.
OMAiSYAFCSD.
OrthoDBiPOG091H07TH.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 2 hits.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

A2C725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVTFLGTSS GVPTRARNVS AVALRLPQRA ELWLFDCGEG TQHQFLRSDL
60 70 80 90 100
RLSQLRRVFV SHMHGDHVFG LPGLLASLGL SGNSNGVDLY GPDPLESYLQ
110 120 130 140 150
GVLRNSSTRI GYPLKVHRVR DAAEQNLIVF EDKDILVRCT PLTHRVPAYA
160 170 180 190 200
YRVEQKPKPG HFNLERAQRL GIPPGPVYAA LKRGEQVSLD DGRVVDGRDF
210 220 230 240 250
CGPDRPGASI VFCTDTVFSE AAVALAAGAD LLIHEATFAH SEAEMAYQKQ
260 270 280 290 300
HSTSTMAAQT AAEAGVGKLV LTHLSPRYAP GNPVTPNDLL REAQAIFSNT
310
ILAKDFLSFE VAPRCNSS
Length:318
Mass (Da):34,612
Last modified:February 20, 2007 - v1
Checksum:i862433E24197E468
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000554 Genomic DNA. Translation: ABM77285.1.
RefSeqiWP_011825207.1. NC_008820.1.

Genome annotation databases

EnsemblBacteriaiABM77285; ABM77285; P9303_05331.
KEGGipmf:P9303_05331.
PATRICi22998497. VBIProMar17757_0571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000554 Genomic DNA. Translation: ABM77285.1.
RefSeqiWP_011825207.1. NC_008820.1.

3D structure databases

ProteinModelPortaliA2C725.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA2C725.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM77285; ABM77285; P9303_05331.
KEGGipmf:P9303_05331.
PATRICi22998497. VBIProMar17757_0571.

Phylogenomic databases

HOGENOMiHOG000272419.
KOiK00784.
OMAiSYAFCSD.
OrthoDBiPOG091H07TH.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 2 hits.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNZ_PROM3
AccessioniPrimary (citable) accession number: A2C725
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.