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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi624 – 631GTPUniRule annotation8
Nucleotide bindingi674 – 678GTPUniRule annotation5
Nucleotide bindingi728 – 731GTPUniRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:P9303_04131
OrganismiProchlorococcus marinus (strain MIT 9303)
Taxonomic identifieri59922 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002274 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000082981 – 1124Translation initiation factor IF-2Add BLAST1124

Structurei

3D structure databases

ProteinModelPortaliA2C6Q5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini615 – 787tr-type GAdd BLAST173

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni624 – 631G1By similarity8
Regioni649 – 653G2By similarity5
Regioni674 – 677G3By similarity4
Regioni728 – 731G4By similarity4
Regioni764 – 766G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076906.
KOiK02519.
OMAiNRPGMPN.
OrthoDBiPOG091H00EY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2C6Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSGKIRIY ELSKDLGLEN KDVLHAAEKL SIAAKSHSSS ISDDEAKRIR
60 70 80 90 100
GLLRQGSAAN SAPPSKSEPG KTILSVKKAA PTAIKDVAPP MRKATSSSEI
110 120 130 140 150
SQVKPSAPAN PTPTSPERLS RESVAHPAPP TRPVNPTTTP TSSPPKTAAR
160 170 180 190 200
PVNAPISRPA TPSRPSAPTP RSANKPSSPV PPSTGSKDPR AGQTSTSSKA
210 220 230 240 250
TTVSGGGPRP KIISRPQSPA APGRSAPPAK PSIPSDRKAP KPELVGRPKP
260 270 280 290 300
KRPVVAPPSR PEPEGQRPDK KRPGISPRPI GGPNQRANTP QRPGAPIRQG
310 320 330 340 350
KTRPGQPRSA GNTLELVGKP IRRDRSDAGS AGRDSNNRPG APTRPGMPAG
360 370 380 390 400
MRKPVAPGEL MQLQKPTGRP GTPPPRRPDG TSVGTRGGSE GATPPVERPA
410 420 430 440 450
SPTAPKRPGH RPAQAPAAGA PRRPGRPDWD DSAKLEALRN KSPQKQRQKV
460 470 480 490 500
HIIGENDDAL TAETSGYAGE QQAVVLTASL ARPAKPKSQK KPASKPVAAL
510 520 530 540 550
RKRKKETTRQ RQRRRAMELR AAREAKQVRP EMLIVPEANL TVQELADMLS
560 570 580 590 600
IESSEIIKSL FFKGITATVT QSLDLPTIEA VAEEFGVPVL QDDIEEAAKK
610 620 630 640 650
TTEMIEETDL AHLIRRPPVV TVMGHVDHGK TSLLDAIRKA RVAAVEAGGI
660 670 680 690 700
TQHIGAYQVE IDHGGQPRKI TFLDTPGHQA FTAMRARGTK VTDIAVLVVA
710 720 730 740 750
ADDGVRPQTL EAISHARAAK VPIIVAINKT DKEGASPERV KQELSDQNLL
760 770 780 790 800
SEEWGGDVVM VPVSAIKGEN IDKLLEMILL VTEVEDLQAN PDRLAKGTVI
810 820 830 840 850
EAHLDKAKGP VATLLIQNGT LKTGDVLAAG PVLGKVRAMV DDSGARLKQA
860 870 880 890 900
GPADAVEALG FSEVPTAGDE FEVYPDEKSA RAVVGERASD ARATRLAQQM
910 920 930 940 950
ASRRVSLAAM SGQASDGELK ELNLILKADV QGSVEAILGS LEQLPKDEVQ
960 970 980 990 1000
VRVLLSAPGE ITETDVDLAA ASGAVIVGFN TSMASGAKRA ADATGVDVRD
1010 1020 1030 1040 1050
YDVIYKLLED IQMAMEGLLE PELVEESLGE AEVRAVFTIG KSAVAGCYIT
1060 1070 1080 1090 1100
TGKLQRNCRV RVRRAKQVVF EGDLDSLRRN KDDVKEVATG FECGIGCDRF
1110 1120
ANWEERDIIE AHKLVTKRRT LSSS
Length:1,124
Mass (Da):119,452
Last modified:February 20, 2007 - v1
Checksum:i48CE8078F7DB8A05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000554 Genomic DNA. Translation: ABM77165.1.
RefSeqiWP_011825090.1. NC_008820.1.

Genome annotation databases

EnsemblBacteriaiABM77165; ABM77165; P9303_04131.
KEGGipmf:P9303_04131.
PATRICi22998243. VBIProMar17757_0445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000554 Genomic DNA. Translation: ABM77165.1.
RefSeqiWP_011825090.1. NC_008820.1.

3D structure databases

ProteinModelPortaliA2C6Q5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM77165; ABM77165; P9303_04131.
KEGGipmf:P9303_04131.
PATRICi22998243. VBIProMar17757_0445.

Phylogenomic databases

HOGENOMiHOG000076906.
KOiK02519.
OMAiNRPGMPN.
OrthoDBiPOG091H00EY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2_PROM3
AccessioniPrimary (citable) accession number: A2C6Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.