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A2C6Q5

- IF2_PROM3

UniProt

A2C6Q5 - IF2_PROM3

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Protein

Translation initiation factor IF-2

Gene
infB, P9303_04131
Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi624 – 6318GTP By similarity
Nucleotide bindingi674 – 6785GTP By similarity
Nucleotide bindingi728 – 7314GTP By similarity

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR59922:GH54-471-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:P9303_04131
OrganismiProchlorococcus marinus (strain MIT 9303)
Taxonomic identifieri59922 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002274: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11241124Translation initiation factor IF-2UniRule annotationPRO_1000008298Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59922.P9303_04131.

Structurei

3D structure databases

ProteinModelPortaliA2C6Q5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini615 – 787173tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni624 – 6318G1 By similarity
Regioni649 – 6535G2 By similarity
Regioni674 – 6774G3 By similarity
Regioni728 – 7314G4 By similarity
Regioni764 – 7663G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiNKPSDQG.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2C6Q5-1 [UniParc]FASTAAdd to Basket

« Hide

MTSSGKIRIY ELSKDLGLEN KDVLHAAEKL SIAAKSHSSS ISDDEAKRIR     50
GLLRQGSAAN SAPPSKSEPG KTILSVKKAA PTAIKDVAPP MRKATSSSEI 100
SQVKPSAPAN PTPTSPERLS RESVAHPAPP TRPVNPTTTP TSSPPKTAAR 150
PVNAPISRPA TPSRPSAPTP RSANKPSSPV PPSTGSKDPR AGQTSTSSKA 200
TTVSGGGPRP KIISRPQSPA APGRSAPPAK PSIPSDRKAP KPELVGRPKP 250
KRPVVAPPSR PEPEGQRPDK KRPGISPRPI GGPNQRANTP QRPGAPIRQG 300
KTRPGQPRSA GNTLELVGKP IRRDRSDAGS AGRDSNNRPG APTRPGMPAG 350
MRKPVAPGEL MQLQKPTGRP GTPPPRRPDG TSVGTRGGSE GATPPVERPA 400
SPTAPKRPGH RPAQAPAAGA PRRPGRPDWD DSAKLEALRN KSPQKQRQKV 450
HIIGENDDAL TAETSGYAGE QQAVVLTASL ARPAKPKSQK KPASKPVAAL 500
RKRKKETTRQ RQRRRAMELR AAREAKQVRP EMLIVPEANL TVQELADMLS 550
IESSEIIKSL FFKGITATVT QSLDLPTIEA VAEEFGVPVL QDDIEEAAKK 600
TTEMIEETDL AHLIRRPPVV TVMGHVDHGK TSLLDAIRKA RVAAVEAGGI 650
TQHIGAYQVE IDHGGQPRKI TFLDTPGHQA FTAMRARGTK VTDIAVLVVA 700
ADDGVRPQTL EAISHARAAK VPIIVAINKT DKEGASPERV KQELSDQNLL 750
SEEWGGDVVM VPVSAIKGEN IDKLLEMILL VTEVEDLQAN PDRLAKGTVI 800
EAHLDKAKGP VATLLIQNGT LKTGDVLAAG PVLGKVRAMV DDSGARLKQA 850
GPADAVEALG FSEVPTAGDE FEVYPDEKSA RAVVGERASD ARATRLAQQM 900
ASRRVSLAAM SGQASDGELK ELNLILKADV QGSVEAILGS LEQLPKDEVQ 950
VRVLLSAPGE ITETDVDLAA ASGAVIVGFN TSMASGAKRA ADATGVDVRD 1000
YDVIYKLLED IQMAMEGLLE PELVEESLGE AEVRAVFTIG KSAVAGCYIT 1050
TGKLQRNCRV RVRRAKQVVF EGDLDSLRRN KDDVKEVATG FECGIGCDRF 1100
ANWEERDIIE AHKLVTKRRT LSSS 1124
Length:1,124
Mass (Da):119,452
Last modified:February 20, 2007 - v1
Checksum:i48CE8078F7DB8A05
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000554 Genomic DNA. Translation: ABM77165.1.
RefSeqiYP_001016430.1. NC_008820.1.

Genome annotation databases

EnsemblBacteriaiABM77165; ABM77165; P9303_04131.
GeneIDi4778381.
KEGGipmf:P9303_04131.
PATRICi22998243. VBIProMar17757_0445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000554 Genomic DNA. Translation: ABM77165.1 .
RefSeqi YP_001016430.1. NC_008820.1.

3D structure databases

ProteinModelPortali A2C6Q5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59922.P9303_04131.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM77165 ; ABM77165 ; P9303_04131 .
GeneIDi 4778381.
KEGGi pmf:P9303_04131.
PATRICi 22998243. VBIProMar17757_0445.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi NKPSDQG.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci PMAR59922:GH54-471-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9303.

Entry informationi

Entry nameiIF2_PROM3
AccessioniPrimary (citable) accession number: A2C6Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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