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A2C6Q5 (IF2_PROM3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:P9303_04131
OrganismProchlorococcus marinus (strain MIT 9303) [Complete proteome] [HAMAP]
Taxonomic identifier59922 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length1124 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11241124Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_1000008298

Regions

Nucleotide binding624 – 6318GTP By similarity
Nucleotide binding674 – 6785GTP By similarity
Nucleotide binding728 – 7314GTP By similarity
Region618 – 770153G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
A2C6Q5 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 48CE8078F7DB8A05

FASTA1,124119,452
        10         20         30         40         50         60 
MTSSGKIRIY ELSKDLGLEN KDVLHAAEKL SIAAKSHSSS ISDDEAKRIR GLLRQGSAAN 

        70         80         90        100        110        120 
SAPPSKSEPG KTILSVKKAA PTAIKDVAPP MRKATSSSEI SQVKPSAPAN PTPTSPERLS 

       130        140        150        160        170        180 
RESVAHPAPP TRPVNPTTTP TSSPPKTAAR PVNAPISRPA TPSRPSAPTP RSANKPSSPV 

       190        200        210        220        230        240 
PPSTGSKDPR AGQTSTSSKA TTVSGGGPRP KIISRPQSPA APGRSAPPAK PSIPSDRKAP 

       250        260        270        280        290        300 
KPELVGRPKP KRPVVAPPSR PEPEGQRPDK KRPGISPRPI GGPNQRANTP QRPGAPIRQG 

       310        320        330        340        350        360 
KTRPGQPRSA GNTLELVGKP IRRDRSDAGS AGRDSNNRPG APTRPGMPAG MRKPVAPGEL 

       370        380        390        400        410        420 
MQLQKPTGRP GTPPPRRPDG TSVGTRGGSE GATPPVERPA SPTAPKRPGH RPAQAPAAGA 

       430        440        450        460        470        480 
PRRPGRPDWD DSAKLEALRN KSPQKQRQKV HIIGENDDAL TAETSGYAGE QQAVVLTASL 

       490        500        510        520        530        540 
ARPAKPKSQK KPASKPVAAL RKRKKETTRQ RQRRRAMELR AAREAKQVRP EMLIVPEANL 

       550        560        570        580        590        600 
TVQELADMLS IESSEIIKSL FFKGITATVT QSLDLPTIEA VAEEFGVPVL QDDIEEAAKK 

       610        620        630        640        650        660 
TTEMIEETDL AHLIRRPPVV TVMGHVDHGK TSLLDAIRKA RVAAVEAGGI TQHIGAYQVE 

       670        680        690        700        710        720 
IDHGGQPRKI TFLDTPGHQA FTAMRARGTK VTDIAVLVVA ADDGVRPQTL EAISHARAAK 

       730        740        750        760        770        780 
VPIIVAINKT DKEGASPERV KQELSDQNLL SEEWGGDVVM VPVSAIKGEN IDKLLEMILL 

       790        800        810        820        830        840 
VTEVEDLQAN PDRLAKGTVI EAHLDKAKGP VATLLIQNGT LKTGDVLAAG PVLGKVRAMV 

       850        860        870        880        890        900 
DDSGARLKQA GPADAVEALG FSEVPTAGDE FEVYPDEKSA RAVVGERASD ARATRLAQQM 

       910        920        930        940        950        960 
ASRRVSLAAM SGQASDGELK ELNLILKADV QGSVEAILGS LEQLPKDEVQ VRVLLSAPGE 

       970        980        990       1000       1010       1020 
ITETDVDLAA ASGAVIVGFN TSMASGAKRA ADATGVDVRD YDVIYKLLED IQMAMEGLLE 

      1030       1040       1050       1060       1070       1080 
PELVEESLGE AEVRAVFTIG KSAVAGCYIT TGKLQRNCRV RVRRAKQVVF EGDLDSLRRN 

      1090       1100       1110       1120 
KDDVKEVATG FECGIGCDRF ANWEERDIIE AHKLVTKRRT LSSS 

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9303.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000554 Genomic DNA. Translation: ABM77165.1.
RefSeqYP_001016430.1. NC_008820.1.

3D structure databases

ProteinModelPortalA2C6Q5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING59922.P9303_04131.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM77165; ABM77165; P9303_04131.
GeneID4778381.
KEGGpmf:P9303_04131.
PATRIC22998243. VBIProMar17757_0445.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMANKPSDQG.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycPMAR59922:GH54-471-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_PROM3
AccessionPrimary (citable) accession number: A2C6Q5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries