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A2C6Q5

- IF2_PROM3

UniProt

A2C6Q5 - IF2_PROM3

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi624 – 6318GTPUniRule annotation
    Nucleotide bindingi674 – 6785GTPUniRule annotation
    Nucleotide bindingi728 – 7314GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR59922:GH54-471-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:P9303_04131
    OrganismiProchlorococcus marinus (strain MIT 9303)
    Taxonomic identifieri59922 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002274: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11241124Translation initiation factor IF-2PRO_1000008298Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi59922.P9303_04131.

    Structurei

    3D structure databases

    ProteinModelPortaliA2C6Q5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini615 – 787173tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni624 – 6318G1By similarity
    Regioni649 – 6535G2By similarity
    Regioni674 – 6774G3By similarity
    Regioni728 – 7314G4By similarity
    Regioni764 – 7663G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiNKPSDQG.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2C6Q5-1 [UniParc]FASTAAdd to Basket

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    MTSSGKIRIY ELSKDLGLEN KDVLHAAEKL SIAAKSHSSS ISDDEAKRIR     50
    GLLRQGSAAN SAPPSKSEPG KTILSVKKAA PTAIKDVAPP MRKATSSSEI 100
    SQVKPSAPAN PTPTSPERLS RESVAHPAPP TRPVNPTTTP TSSPPKTAAR 150
    PVNAPISRPA TPSRPSAPTP RSANKPSSPV PPSTGSKDPR AGQTSTSSKA 200
    TTVSGGGPRP KIISRPQSPA APGRSAPPAK PSIPSDRKAP KPELVGRPKP 250
    KRPVVAPPSR PEPEGQRPDK KRPGISPRPI GGPNQRANTP QRPGAPIRQG 300
    KTRPGQPRSA GNTLELVGKP IRRDRSDAGS AGRDSNNRPG APTRPGMPAG 350
    MRKPVAPGEL MQLQKPTGRP GTPPPRRPDG TSVGTRGGSE GATPPVERPA 400
    SPTAPKRPGH RPAQAPAAGA PRRPGRPDWD DSAKLEALRN KSPQKQRQKV 450
    HIIGENDDAL TAETSGYAGE QQAVVLTASL ARPAKPKSQK KPASKPVAAL 500
    RKRKKETTRQ RQRRRAMELR AAREAKQVRP EMLIVPEANL TVQELADMLS 550
    IESSEIIKSL FFKGITATVT QSLDLPTIEA VAEEFGVPVL QDDIEEAAKK 600
    TTEMIEETDL AHLIRRPPVV TVMGHVDHGK TSLLDAIRKA RVAAVEAGGI 650
    TQHIGAYQVE IDHGGQPRKI TFLDTPGHQA FTAMRARGTK VTDIAVLVVA 700
    ADDGVRPQTL EAISHARAAK VPIIVAINKT DKEGASPERV KQELSDQNLL 750
    SEEWGGDVVM VPVSAIKGEN IDKLLEMILL VTEVEDLQAN PDRLAKGTVI 800
    EAHLDKAKGP VATLLIQNGT LKTGDVLAAG PVLGKVRAMV DDSGARLKQA 850
    GPADAVEALG FSEVPTAGDE FEVYPDEKSA RAVVGERASD ARATRLAQQM 900
    ASRRVSLAAM SGQASDGELK ELNLILKADV QGSVEAILGS LEQLPKDEVQ 950
    VRVLLSAPGE ITETDVDLAA ASGAVIVGFN TSMASGAKRA ADATGVDVRD 1000
    YDVIYKLLED IQMAMEGLLE PELVEESLGE AEVRAVFTIG KSAVAGCYIT 1050
    TGKLQRNCRV RVRRAKQVVF EGDLDSLRRN KDDVKEVATG FECGIGCDRF 1100
    ANWEERDIIE AHKLVTKRRT LSSS 1124
    Length:1,124
    Mass (Da):119,452
    Last modified:February 20, 2007 - v1
    Checksum:i48CE8078F7DB8A05
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000554 Genomic DNA. Translation: ABM77165.1.
    RefSeqiYP_001016430.1. NC_008820.1.

    Genome annotation databases

    EnsemblBacteriaiABM77165; ABM77165; P9303_04131.
    GeneIDi4778381.
    KEGGipmf:P9303_04131.
    PATRICi22998243. VBIProMar17757_0445.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000554 Genomic DNA. Translation: ABM77165.1 .
    RefSeqi YP_001016430.1. NC_008820.1.

    3D structure databases

    ProteinModelPortali A2C6Q5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59922.P9303_04131.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM77165 ; ABM77165 ; P9303_04131 .
    GeneIDi 4778381.
    KEGGi pmf:P9303_04131.
    PATRICi 22998243. VBIProMar17757_0445.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi NKPSDQG.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci PMAR59922:GH54-471-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9303.

    Entry informationi

    Entry nameiIF2_PROM3
    AccessioniPrimary (citable) accession number: A2C6Q5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3