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A2C6Q5

- IF2_PROM3

UniProt

A2C6Q5 - IF2_PROM3

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi624 – 6318GTPUniRule annotation
Nucleotide bindingi674 – 6785GTPUniRule annotation
Nucleotide bindingi728 – 7314GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR59922:GH54-471-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:P9303_04131
OrganismiProchlorococcus marinus (strain MIT 9303)
Taxonomic identifieri59922 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002274: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11241124Translation initiation factor IF-2PRO_1000008298Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59922.P9303_04131.

Structurei

3D structure databases

ProteinModelPortaliA2C6Q5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini615 – 787173tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni624 – 6318G1By similarity
Regioni649 – 6535G2By similarity
Regioni674 – 6774G3By similarity
Regioni728 – 7314G4By similarity
Regioni764 – 7663G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiNKPSDQG.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2C6Q5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSSGKIRIY ELSKDLGLEN KDVLHAAEKL SIAAKSHSSS ISDDEAKRIR
60 70 80 90 100
GLLRQGSAAN SAPPSKSEPG KTILSVKKAA PTAIKDVAPP MRKATSSSEI
110 120 130 140 150
SQVKPSAPAN PTPTSPERLS RESVAHPAPP TRPVNPTTTP TSSPPKTAAR
160 170 180 190 200
PVNAPISRPA TPSRPSAPTP RSANKPSSPV PPSTGSKDPR AGQTSTSSKA
210 220 230 240 250
TTVSGGGPRP KIISRPQSPA APGRSAPPAK PSIPSDRKAP KPELVGRPKP
260 270 280 290 300
KRPVVAPPSR PEPEGQRPDK KRPGISPRPI GGPNQRANTP QRPGAPIRQG
310 320 330 340 350
KTRPGQPRSA GNTLELVGKP IRRDRSDAGS AGRDSNNRPG APTRPGMPAG
360 370 380 390 400
MRKPVAPGEL MQLQKPTGRP GTPPPRRPDG TSVGTRGGSE GATPPVERPA
410 420 430 440 450
SPTAPKRPGH RPAQAPAAGA PRRPGRPDWD DSAKLEALRN KSPQKQRQKV
460 470 480 490 500
HIIGENDDAL TAETSGYAGE QQAVVLTASL ARPAKPKSQK KPASKPVAAL
510 520 530 540 550
RKRKKETTRQ RQRRRAMELR AAREAKQVRP EMLIVPEANL TVQELADMLS
560 570 580 590 600
IESSEIIKSL FFKGITATVT QSLDLPTIEA VAEEFGVPVL QDDIEEAAKK
610 620 630 640 650
TTEMIEETDL AHLIRRPPVV TVMGHVDHGK TSLLDAIRKA RVAAVEAGGI
660 670 680 690 700
TQHIGAYQVE IDHGGQPRKI TFLDTPGHQA FTAMRARGTK VTDIAVLVVA
710 720 730 740 750
ADDGVRPQTL EAISHARAAK VPIIVAINKT DKEGASPERV KQELSDQNLL
760 770 780 790 800
SEEWGGDVVM VPVSAIKGEN IDKLLEMILL VTEVEDLQAN PDRLAKGTVI
810 820 830 840 850
EAHLDKAKGP VATLLIQNGT LKTGDVLAAG PVLGKVRAMV DDSGARLKQA
860 870 880 890 900
GPADAVEALG FSEVPTAGDE FEVYPDEKSA RAVVGERASD ARATRLAQQM
910 920 930 940 950
ASRRVSLAAM SGQASDGELK ELNLILKADV QGSVEAILGS LEQLPKDEVQ
960 970 980 990 1000
VRVLLSAPGE ITETDVDLAA ASGAVIVGFN TSMASGAKRA ADATGVDVRD
1010 1020 1030 1040 1050
YDVIYKLLED IQMAMEGLLE PELVEESLGE AEVRAVFTIG KSAVAGCYIT
1060 1070 1080 1090 1100
TGKLQRNCRV RVRRAKQVVF EGDLDSLRRN KDDVKEVATG FECGIGCDRF
1110 1120
ANWEERDIIE AHKLVTKRRT LSSS
Length:1,124
Mass (Da):119,452
Last modified:February 20, 2007 - v1
Checksum:i48CE8078F7DB8A05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000554 Genomic DNA. Translation: ABM77165.1.
RefSeqiWP_011825090.1. NC_008820.1.
YP_001016430.1. NC_008820.1.

Genome annotation databases

EnsemblBacteriaiABM77165; ABM77165; P9303_04131.
GeneIDi4778381.
KEGGipmf:P9303_04131.
PATRICi22998243. VBIProMar17757_0445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000554 Genomic DNA. Translation: ABM77165.1 .
RefSeqi WP_011825090.1. NC_008820.1.
YP_001016430.1. NC_008820.1.

3D structure databases

ProteinModelPortali A2C6Q5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59922.P9303_04131.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM77165 ; ABM77165 ; P9303_04131 .
GeneIDi 4778381.
KEGGi pmf:P9303_04131.
PATRICi 22998243. VBIProMar17757_0445.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi NKPSDQG.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci PMAR59922:GH54-471-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9303.

Entry informationi

Entry nameiIF2_PROM3
AccessioniPrimary (citable) accession number: A2C6Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3