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A2C5D4

- GCSP_PROM1

UniProt

A2C5D4 - GCSP_PROM1

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Prochlorococcus marinus (strain NATL1A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPMAR167555:GI3K-2186-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:NATL1_21381
    OrganismiProchlorococcus marinus (strain NATL1A)
    Taxonomic identifieri167555 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002592: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 968968Glycine dehydrogenase (decarboxylating)PRO_1000045594Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei712 – 7121N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi167555.NATL1_21381.

    Structurei

    3D structure databases

    ProteinModelPortaliA2C5D4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2C5D4-1 [UniParc]FASTAAdd to Basket

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    MSKAELKDFT FKSRHIGPTN EDEALMLQHL GYENSEEFIS SVIPNEIFDS    50
    ENNVVSIPDG CDQNKALKEI NIISKKNVEH RSLIGLGYHS TVIPPVIQRN 100
    VLENPNWYTA YTPYQAEISQ GRLEALFNFQ TLISELTGLP ISNASLLDEA 150
    TAAAEAISLS LAVRKNKNAN KFLVDQEILP QTFDVLKTRC EPLGISLEMF 200
    ENNNFEIDKN IFGILIQLPG KNGRIWDPTK IINDAHKCNA IVTIAIDPLA 250
    QVLIKPMGEF GADIVVGSAQ RFGVPIACGG PHAAFFATKE IYKRQIPGRI 300
    VGQSVDVEGN QALRLALQTR EQHIRRDKAT SNICTAQVLL AVLSSFYAVH 350
    HGPKGLKQIA ENVVKYRSNF ESILMNLEYP IEKYSAFDSV DVYCSEASEV 400
    IQLASEEGYN FRVLPIGSDF ENAKGFGVTF DELTCDEEIY TLHQILAQVK 450
    GKKAHDLSNF LNENASLVDI PLREKSWLEQ SVFNQYQSET DLMRYIHSLV 500
    SKDFSLVQGM IPLGSCTMKL NSAAELLPIE WREFSSIHPF APHAQLAGFH 550
    EIINDLENWL SALTGFQGVS LQPNAGSQGE FAGLLVIRSW HQSLGEGHRN 600
    ICLIPTSAHG TNPASAVMSG FKVVSVKCDE YGNVDLEDLK NKSKIHSKNL 650
    AALMVTYPST HGVFEPNIRE MCQVIHQEGG QVYLDGANLN AQVGICRPGS 700
    YGIDVCHLNL HKTFSIPHGG GGPGVGPIAV ADHLVPYLPG HSIIKCGGEK 750
    AISAVSAAPF GSAGILPISW MYIRMMGSDG LRKASSIAIL SANYLAKRLD 800
    PYYPVLFKDP NGLVAHECIL DLRPLKSQLG IEVEDVAKRL MDYGFHAPTI 850
    SWPVAGTLMV EPTESESLPE LDRFCDAMIG IREEIEQIKL GKIDPINNPL 900
    KQSPHTLKRV TSDDWDRPYS RKEAAYPLPD QEKYKFWPSV SRINNAYGDR 950
    NLICSCPSVQ DLEDINSV 968
    Length:968
    Mass (Da):107,028
    Last modified:February 20, 2007 - v1
    Checksum:i84FEBA73081CEF65
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000553 Genomic DNA. Translation: ABM76694.1.
    RefSeqiWP_011824632.1. NC_008819.1.
    YP_001015958.1. NC_008819.1.

    Genome annotation databases

    EnsemblBacteriaiABM76694; ABM76694; NATL1_21381.
    GeneIDi4780859.
    KEGGipme:NATL1_21381.
    PATRICi23021945. VBIProMar31285_2181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000553 Genomic DNA. Translation: ABM76694.1 .
    RefSeqi WP_011824632.1. NC_008819.1.
    YP_001015958.1. NC_008819.1.

    3D structure databases

    ProteinModelPortali A2C5D4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167555.NATL1_21381.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM76694 ; ABM76694 ; NATL1_21381 .
    GeneIDi 4780859.
    KEGGi pme:NATL1_21381.
    PATRICi 23021945. VBIProMar31285_2181.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PMAR167555:GI3K-2186-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NATL1A.

    Entry informationi

    Entry nameiGCSP_PROM1
    AccessioniPrimary (citable) accession number: A2C5D4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3