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A2C5D4

- GCSP_PROM1

UniProt

A2C5D4 - GCSP_PROM1

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, NATL1_21381
Organism
Prochlorococcus marinus (strain NATL1A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMAR167555:GI3K-2186-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:NATL1_21381
OrganismiProchlorococcus marinus (strain NATL1A)
Taxonomic identifieri167555 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 968968Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000045594Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei712 – 7121N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi167555.NATL1_21381.

Structurei

3D structure databases

ProteinModelPortaliA2C5D4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A2C5D4-1 [UniParc]FASTAAdd to Basket

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MSKAELKDFT FKSRHIGPTN EDEALMLQHL GYENSEEFIS SVIPNEIFDS    50
ENNVVSIPDG CDQNKALKEI NIISKKNVEH RSLIGLGYHS TVIPPVIQRN 100
VLENPNWYTA YTPYQAEISQ GRLEALFNFQ TLISELTGLP ISNASLLDEA 150
TAAAEAISLS LAVRKNKNAN KFLVDQEILP QTFDVLKTRC EPLGISLEMF 200
ENNNFEIDKN IFGILIQLPG KNGRIWDPTK IINDAHKCNA IVTIAIDPLA 250
QVLIKPMGEF GADIVVGSAQ RFGVPIACGG PHAAFFATKE IYKRQIPGRI 300
VGQSVDVEGN QALRLALQTR EQHIRRDKAT SNICTAQVLL AVLSSFYAVH 350
HGPKGLKQIA ENVVKYRSNF ESILMNLEYP IEKYSAFDSV DVYCSEASEV 400
IQLASEEGYN FRVLPIGSDF ENAKGFGVTF DELTCDEEIY TLHQILAQVK 450
GKKAHDLSNF LNENASLVDI PLREKSWLEQ SVFNQYQSET DLMRYIHSLV 500
SKDFSLVQGM IPLGSCTMKL NSAAELLPIE WREFSSIHPF APHAQLAGFH 550
EIINDLENWL SALTGFQGVS LQPNAGSQGE FAGLLVIRSW HQSLGEGHRN 600
ICLIPTSAHG TNPASAVMSG FKVVSVKCDE YGNVDLEDLK NKSKIHSKNL 650
AALMVTYPST HGVFEPNIRE MCQVIHQEGG QVYLDGANLN AQVGICRPGS 700
YGIDVCHLNL HKTFSIPHGG GGPGVGPIAV ADHLVPYLPG HSIIKCGGEK 750
AISAVSAAPF GSAGILPISW MYIRMMGSDG LRKASSIAIL SANYLAKRLD 800
PYYPVLFKDP NGLVAHECIL DLRPLKSQLG IEVEDVAKRL MDYGFHAPTI 850
SWPVAGTLMV EPTESESLPE LDRFCDAMIG IREEIEQIKL GKIDPINNPL 900
KQSPHTLKRV TSDDWDRPYS RKEAAYPLPD QEKYKFWPSV SRINNAYGDR 950
NLICSCPSVQ DLEDINSV 968
Length:968
Mass (Da):107,028
Last modified:February 20, 2007 - v1
Checksum:i84FEBA73081CEF65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000553 Genomic DNA. Translation: ABM76694.1.
RefSeqiWP_011824632.1. NC_008819.1.
YP_001015958.1. NC_008819.1.

Genome annotation databases

EnsemblBacteriaiABM76694; ABM76694; NATL1_21381.
GeneIDi4780859.
KEGGipme:NATL1_21381.
PATRICi23021945. VBIProMar31285_2181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000553 Genomic DNA. Translation: ABM76694.1 .
RefSeqi WP_011824632.1. NC_008819.1.
YP_001015958.1. NC_008819.1.

3D structure databases

ProteinModelPortali A2C5D4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167555.NATL1_21381.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM76694 ; ABM76694 ; NATL1_21381 .
GeneIDi 4780859.
KEGGi pme:NATL1_21381.
PATRICi 23021945. VBIProMar31285_2181.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PMAR167555:GI3K-2186-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL1A.

Entry informationi

Entry nameiGCSP_PROM1
AccessioniPrimary (citable) accession number: A2C5D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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