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Protein

UvrABC system protein B

Gene

uvrB

Organism
Prochlorococcus marinus (strain NATL1A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease, Helicase, Hydrolase
Biological processDNA damage, DNA excision, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotation
Ordered Locus Names:NATL1_21171
OrganismiProchlorococcus marinus (strain NATL1A)
Taxonomic identifieri167555 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002592 Componenti: Chromosome

Subcellular locationi

A2C5B3:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000779091 – 678UvrABC system protein BAdd BLAST678

Proteomic databases

PRIDEiA2C5B3.

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi167555.NATL1_21171.

Structurei

3D structure databases

ProteinModelPortaliA2C5B3.
SMRiA2C5B3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 176Helicase ATP-bindingUniRule annotationAdd BLAST152
Domaini429 – 591Helicase C-terminalUniRule annotationAdd BLAST163
Domaini639 – 674UVRUniRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi91 – 114Beta-hairpinAdd BLAST24

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCW. Bacteria.
COG0556. LUCA.
HOGENOMiHOG000073580.
KOiK03702.
OMAiRYMHSEI.
OrthoDBiPOG091H02LK.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
Gene3Di4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB. 1 hit.
InterProiView protein in InterPro
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.

Sequencei

Sequence statusi: Complete.

A2C5B3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEYKLQAPY TPKGDQPAAI KGLVGGVNDG EKFQTLLGAT GTGKTFTIAN
60 70 80 90 100
LIAQTGRPAL VLAHNKTLAA QLCNELREFF PDNAVEYFIS YYDYYQPEAY
110 120 130 140 150
VPVSDTYIAK TSSINEEIDM LRHSATRSLF ERDDVIVVAS ISCIYGLGIP
160 170 180 190 200
SEYLKASVKF QVGQSIDLRS CLRSLVSNQY TRNDIEISRG RFRVRGDVLE
210 220 230 240 250
IGPAYDDRLV RLELFGDEVE SISYVDPTTG EILNKLDSIN IYPAKHFVTP
260 270 280 290 300
KDRLDSAIKA IKKELKDRLE FLNQEGKLLE AQRLEQRTIY DLEMLKEVGY
310 320 330 340 350
CNGVENYARH LSGREPGSAP ECLIDYFPKD WLLLIDESHV TCPQLRAMYN
360 370 380 390 400
GDQARKKVLI DHGFRLPSAA DNRPLKDIEF WNKAKQTVFI SATPGDWELS
410 420 430 440 450
QSTKNIVEQV IRPTGVLDPL VEVRPTHGQV DDLLFEIRKR ASKNQRILVT
460 470 480 490 500
TLTKRMAEDL TDYLSENKIR VRYLHSEIHS IERIEIIQDL RLGEYDVLVG
510 520 530 540 550
VNLLREGLDL PEVSLVVILD ADKEGFLRAQ RSLIQTIGRA ARHVEGLALL
560 570 580 590 600
YADKMTDSMA KAISETERRR EIQNIYNIEH GITPKPAGKK ASNSILSFLE
610 620 630 640 650
ISRRLNQDGS TDDFVDIADK LIEHSAKDSD SGVSLESLPE LIEKLESKMK
660 670
IKAKDLDFEK AAILRDRIKK LRHRLVGR
Length:678
Mass (Da):76,771
Last modified:February 20, 2007 - v1
Checksum:i677F11BDF606FFE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000553 Genomic DNA. Translation: ABM76673.1.
RefSeqiWP_011824617.1. NC_008819.1.

Genome annotation databases

EnsemblBacteriaiABM76673; ABM76673; NATL1_21171.
KEGGipme:NATL1_21171.

Similar proteinsi

Entry informationi

Entry nameiUVRB_PROM1
AccessioniPrimary (citable) accession number: A2C5B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 20, 2007
Last modified: October 25, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families