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Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Prochlorococcus marinus (strain NATL1A)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation
Displays a CMP kinase activity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361Proton donorUniRule annotation
Binding sitei64 – 641Beta-alanineUniRule annotation
Binding sitei64 – 641PantoateUniRule annotation
Binding sitei159 – 1591PantoateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 368ATPUniRule annotation
Nucleotide bindingi153 – 1564ATPUniRule annotation
Nucleotide bindingi190 – 1934ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cytidylate kinase activity Source: UniProtKB-HAMAP
  3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
  2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ligase, Transferase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR167555:GI3K-2085-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
Including the following 2 domains:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Cytidylate kinaseUniRule annotation (EC:2.7.4.14UniRule annotation)
Short name:
CKUniRule annotation
Alternative name(s):
Cytidine monophosphate kinaseUniRule annotation
Short name:
CMP kinaseUniRule annotation
Gene namesi
Name:panC/cmkUniRule annotation
Ordered Locus Names:NATL1_20401
OrganismiProchlorococcus marinus (strain NATL1A)
Taxonomic identifieri167555 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002592 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Bifunctional pantoate ligase/cytidylate kinasePRO_0000333299Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167555.NATL1_20401.

Structurei

3D structure databases

ProteinModelPortaliA2C536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 279279Pantoate--beta-alanine ligaseAdd
BLAST
Regioni280 – 516237Cytidylate kinaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.UniRule annotation
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0283.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

A2C536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRKIFQTNA ELKDWLSEQN SAIIFIPTMG GLHPGHQYLI QKAKERKTNT
60 70 80 90 100
NQIILVSIFV NPLQFSKGED FKKYPRNINR DAELAFSAGA DAIWAPDYDE
110 120 130 140 150
VFPGGADSHF KIEVPKTLHN QLCGAERKGH FDGVATVIIR LIKIIKPKKL
160 170 180 190 200
VLGEKDWQQL IIIRKLFQEL SIPVKIESYS TQRDQSGFAY SSRNSYLSDS
210 220 230 240 250
ERVNAQSLPN AIKEAKTEFD KGKVINLTKI ASIFKENNLK IEYLKIVDPF
260 270 280 290 300
SLKETENINR LCLLAVAVKC GSTRLIDHTF LMHRKPIIAI DGPAGAGKST
310 320 330 340 350
VTKAFAKKLG FIYLDTGAMY RAVTWLIISN SIDPNDQVEI KNILKDSKLE
360 370 380 390 400
FKSSSFVEQK IFINNIDVTE KIRSPKVTSM VSEIAKQQFV RELLTRKQQV
410 420 430 440 450
IGNNGGLVAE GRDIGTAVFP DADLKIFLTA SPTERAKRRA LDLHKRGYEF
460 470 480 490 500
SSIEDLEKEI KERDKKDSER KIAPLKKAQD AIELVTDGMN IEDVLKELID
510
IFRSKIPEEV WPTPNS
Length:516
Mass (Da):58,348
Last modified:February 20, 2007 - v1
Checksum:i6F1E35E3BFD96C4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000553 Genomic DNA. Translation: ABM76596.1.
RefSeqiYP_001015860.1. NC_008819.1.

Genome annotation databases

EnsemblBacteriaiABM76596; ABM76596; NATL1_20401.
KEGGipme:NATL1_20401.
PATRICi23021743. VBIProMar31285_2082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000553 Genomic DNA. Translation: ABM76596.1.
RefSeqiYP_001015860.1. NC_008819.1.

3D structure databases

ProteinModelPortaliA2C536.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi167555.NATL1_20401.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM76596; ABM76596; NATL1_20401.
KEGGipme:NATL1_20401.
PATRICi23021743. VBIProMar31285_2082.

Phylogenomic databases

eggNOGiCOG0283.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiEOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.
BioCyciPMAR167555:GI3K-2085-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL1A.

Entry informationi

Entry nameiPANCY_PROM1
AccessioniPrimary (citable) accession number: A2C536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 20, 2007
Last modified: April 1, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.