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A2C535

- PUR5_PROM1

UniProt

A2C535 - PUR5_PROM1

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Prochlorococcus marinus (strain NATL1A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR167555:GI3K-2084-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:NATL1_20391
    OrganismiProchlorococcus marinus (strain NATL1A)
    Taxonomic identifieri167555 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002592: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000046454Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi167555.NATL1_20391.

    Structurei

    3D structure databases

    ProteinModelPortaliA2C535.
    SMRiA2C535. Positions 1-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiEFEMYRT.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2C535-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYKTAGVDV TAGRAFVERI KSCVEKTHKS EVIGGLGGFG GCIRIPKGFE    50
    SPVLVSGTDG VGTKLELAQQ YGCHFGVGID LVAMCVNDVI TNGARPLFFL 100
    DYIASGTLTP DALAEVIEGI AAGCCQSDCS LLGGETAEMP GFYPSGRYDL 150
    AGFCVGIVEN HHLIDGTKIN CGDQIIGIKS NGVHSNGFSL VRKVLSMANV 200
    DENTLYGKDK RNLIQSLLEP TAIYVQLVEK LLRENLPIHG MTHITGGGLP 250
    ENLPRIFPSG LLPHIDITTW EITEIFNWLQ NAGDIPEIDL WNTFNMGIGF 300
    CLIVPKNEVN SALEICMKND FEAWNIGQVV ESQNNSKHSG ILGIPS 346
    Length:346
    Mass (Da):37,255
    Last modified:February 20, 2007 - v1
    Checksum:i55F2D29468FBB178
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000553 Genomic DNA. Translation: ABM76595.1.
    RefSeqiWP_011824545.1. NC_008819.1.
    YP_001015859.1. NC_008819.1.

    Genome annotation databases

    EnsemblBacteriaiABM76595; ABM76595; NATL1_20391.
    GeneIDi4779866.
    KEGGipme:NATL1_20391.
    PATRICi23021741. VBIProMar31285_2081.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000553 Genomic DNA. Translation: ABM76595.1 .
    RefSeqi WP_011824545.1. NC_008819.1.
    YP_001015859.1. NC_008819.1.

    3D structure databases

    ProteinModelPortali A2C535.
    SMRi A2C535. Positions 1-335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167555.NATL1_20391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM76595 ; ABM76595 ; NATL1_20391 .
    GeneIDi 4779866.
    KEGGi pme:NATL1_20391.
    PATRICi 23021741. VBIProMar31285_2081.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi EFEMYRT.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci PMAR167555:GI3K-2084-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NATL1A.

    Entry informationi

    Entry nameiPUR5_PROM1
    AccessioniPrimary (citable) accession number: A2C535
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3