A2C4K6 (A2C4K6_PROM1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NADPH-dependent 7-cyano-7-deazaguanine reductase HAMAP MF_00818
EC=1.7.1.13 HAMAP MF_00818

Alternative name(s):
7-cyano-7-carbaguanine reductase HAMAP MF_00818
NADPH-dependent nitrile oxidoreductase HAMAP MF_00818
PreQ(0) reductase HAMAP MF_00818

Gene names

Name:	queF HAMAP MF_00818
Ordered Locus Names:	NATL1_18601

Organism

Prochlorococcus marinus (strain NATL1A) [Complete proteome] [HAMAP] EMBL ABM76416.1

Taxonomic identifier

167555 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) By similarity. HAMAP MF_00818
Catalytic activity	7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH. HAMAP MF_00818
Pathway	tRNA modification; tRNA-queuosine biosynthesis. HAMAP MF_00818
Subcellular location	Cytoplasm By similarity HAMAP MF_00818.
Sequence similarities	Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. HAMAP MF_00818

Ontologies

Keywords
Biological process	Queuosine biosynthesis HAMAP MF_00818
Cellular component	Cytoplasm HAMAP MF_00818
Ligand	NADP HAMAP MF_00818
Molecular function	Hydrolase EMBL ABM76416.1 Oxidoreductase HAMAP MF_00818
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	queuosine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor Inferred from electronic annotation. Source: HAMAP preQ1 synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2C4K6 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 40621FB275D1550D	FASTA	128	14,955
	10 20 30 40 50 60 MYGEREIEAG SLICFPNPNI NRDYEISIDF PEFTCKCPFS GYPDFATLKI KYQPNTKVIE 70 80 90 100 110 120 LKAIKLYLNS FREKKISHEE VTNKIIDDFV EVSDPKWMQL EADFNPRGNV HTIIRVCHGK RKNLDLIL

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000553 Genomic DNA. Translation: ABM76416.1.
RefSeq	YP_001015680.1. NC_008819.1.
3D structure databases
ProteinModelPortal	A2C4K6.
ModBase	Search...
Protein-protein interaction databases
STRING	A2C4K6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4780427.
GenomeReviews	Gene locus NATL1_18601 in contig CP000553_GR.
KEGG	pme:NATL1_18601.
PATRIC	23021369. VBIProMar31285_1899.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0780.
HOGENOM	HBG294103.
OMA	FRNAGIF.
PhylomeDB	A2C4K6.
ProtClustDB	PRK13258.
Enzyme and pathway databases
BioCyc	PMAR167555:NATL1_18601-MONOMER.
Family and domain databases
HAMAP	MF_00818. QueF_type1. [Tree]
InterPro	IPR016856. CN_OxRdtase_NADPH-dep_QueF. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. [Graphical view]
KO	K09457.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
PIRSF	PIRSF027377. Nitrile_oxidored_QueF. 1 hit.
TIGRFAMs	TIGR03139. QueF-II. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A2C4K6_PROM1

Accession

Primary (citable) accession number: A2C4K6

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)