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Protein

Ribonuclease Z

Gene

rnz

Organism
Prochlorococcus marinus (strain NATL1A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Zinc 1; catalyticUniRule annotation
Metal bindingi64 – 641Zinc 1; catalyticUniRule annotation
Active sitei66 – 661Proton acceptorUniRule annotation
Metal bindingi66 – 661Zinc 2; catalyticUniRule annotation
Metal bindingi67 – 671Zinc 2; catalyticUniRule annotation
Metal bindingi144 – 1441Zinc 1; catalyticUniRule annotation
Metal bindingi215 – 2151Zinc 1; catalyticUniRule annotation
Metal bindingi215 – 2151Zinc 2; catalyticUniRule annotation
Metal bindingi273 – 2731Zinc 2; catalyticUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciPMAR167555:GI3K-1815-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:NATL1_17761
OrganismiProchlorococcus marinus (strain NATL1A)
Taxonomic identifieri167555 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
Proteomesi
  • UP000002592 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Ribonuclease ZPRO_1000070314Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi167555.NATL1_17761.

Structurei

3D structure databases

ProteinModelPortaliA2C4C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105IES. Bacteria.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiWYLVDCG.
OrthoDBiEOG61P6TK.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 2 hits.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

A2C4C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVTFLGTSS GVPTLNRNVS AMVLKPPQRS ELWLFDCGEG TQHQFIRSNL
60 70 80 90 100
KLSQIKKIFI THMHGDHIYG LPGLLASIGL AGSSSGIELY GPAPLKNFID
110 120 130 140 150
SCLYNSSSRL AYSLKFHRVE NAANNKEILF EDSELEVKTA PLKHRIPSFA
160 170 180 190 200
YRVNQKTRPG RFDIEKAKLK GIPPGPVYAD LQRGEEVRLE DGRIFSGKEF
210 220 230 240 250
CGPPRPGVSM VYCTDTVYTE SAIEISRKAD LLIHESTYSY KETEMAYERG
260 270 280 290 300
HSTATMAAQI AAKANVDQLI LTHLSPRYTP GNQTCPNDLL NEAKAIFPNT
310
QLAKDFLQID LNKS
Length:314
Mass (Da):34,938
Last modified:February 20, 2007 - v1
Checksum:i802EEA816545A63A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000553 Genomic DNA. Translation: ABM76332.1.
RefSeqiWP_011824326.1. NC_008819.1.

Genome annotation databases

EnsemblBacteriaiABM76332; ABM76332; NATL1_17761.
KEGGipme:NATL1_17761.
PATRICi23021189. VBIProMar31285_1810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000553 Genomic DNA. Translation: ABM76332.1.
RefSeqiWP_011824326.1. NC_008819.1.

3D structure databases

ProteinModelPortaliA2C4C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi167555.NATL1_17761.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM76332; ABM76332; NATL1_17761.
KEGGipme:NATL1_17761.
PATRICi23021189. VBIProMar31285_1810.

Phylogenomic databases

eggNOGiENOG4105IES. Bacteria.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiWYLVDCG.
OrthoDBiEOG61P6TK.

Enzyme and pathway databases

BioCyciPMAR167555:GI3K-1815-MONOMER.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 2 hits.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL1A.

Entry informationi

Entry nameiRNZ_PROM1
AccessioniPrimary (citable) accession number: A2C4C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.