A2C4A6 (A2C4A6_PROM1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 2 HAMAP MF_01401
Short name=Protein-methionine-S-oxide reductase 2 HAMAP MF_01401
EC=1.8.4.11 HAMAP MF_01401

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 2 HAMAP MF_01401

Gene names

Name:	msrA2 HAMAP MF_01401
Ordered Locus Names:	NATL1_17601

Organism

Prochlorococcus marinus (strain NATL1A) [Complete proteome] [HAMAP] EMBL ABM76316.1

Taxonomic identifier

167555 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family. HAMAP MF_01401

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP MF_01401 EMBL ABM76316.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	41	1	By similarity HAMAP MF_01401

Sequences

	Sequence		Length	Mass (Da)
	A2C4A6 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: CE791BAFAB380396	FASTA	203	23,426
	10 20 30 40 50 60 MIAMNKIFRR LIVFSILLQL LIACPLKAFA ESEEAIFAGG CFWCLEHDLE KLDGVVSAES 70 80 90 100 110 120 GYSGGDLINP TYQDHSGHQE VVKVIFDSDI ISYKDLLKQY WVNIDPFDNN GQFCDRGDSY 130 140 150 160 170 180 KPVIFTSNQE QKRDAKESQE TISVGLNIPL EQLKVDIVES KVFWLAENYH QDFAVKNPLK 190 200 YNFYRTSCGR DNRLKKVWGE YKY

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000553 Genomic DNA. Translation: ABM76316.1.
RefSeq	YP_001015580.1. NC_008819.1.
3D structure databases
ProteinModelPortal	A2C4A6.
ModBase	Search...
Protein-protein interaction databases
STRING	A2C4A6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4780084.
GenomeReviews	Gene locus NATL1_17601 in contig CP000553_GR.
KEGG	pme:NATL1_17601.
PATRIC	23021157. VBIProMar31285_1794.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	KIEYDVA.
PhylomeDB	A2C4A6.
ProtClustDB	CLSK716011.
Enzyme and pathway databases
BioCyc	PMAR167555:NATL1_17601-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A2C4A6_PROM1

Accession

Primary (citable) accession number: A2C4A6

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)