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A2C405 (RNPA_PROM1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein component

Short name=RNase P protein
Short name=RNaseP protein
EC=3.1.26.5
Alternative name(s):
Protein C5
Gene names
Name:rnpA
Ordered Locus Names:NATL1_16581
OrganismProchlorococcus marinus (strain NATL1A) [Complete proteome] [HAMAP]
Taxonomic identifier167555 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length128 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme By similarity. HAMAP-Rule MF_00227

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP-Rule MF_00227

Subunit structure

Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit By similarity.

Sequence similarities

Belongs to the RnpA family.

Ontologies

Keywords
   Biological processtRNA processing
   LigandRNA-binding
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionribonuclease P activity

Inferred from electronic annotation. Source: UniProtKB-EC

tRNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 128128Ribonuclease P protein component HAMAP-Rule MF_00227
PRO_1000194663

Sequences

Sequence LengthMass (Da)Tools
A2C405 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 2F18C278A32EF985

FASTA12814,761
        10         20         30         40         50         60 
MVLPKHMRLK GHRCFDFIYK EGSRFYSSSM VLRVTDANKK PQVKGKQSKT RPSIKCAISI 

        70         80         90        100        110        120 
SNKVSKKSVT RNKLRRLFHH HLSLRLSNMS CDKEIWAFIS LKPSSMKNSY STLLKECDKL 


LTKAGITK 

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NATL1A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000553 Genomic DNA. Translation: ABM76215.1.
RefSeqYP_001015480.1. NC_008819.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167555.NATL1_16581.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM76215; ABM76215; NATL1_16581.
GeneID4779405.
KEGGpme:NATL1_16581.
PATRIC23020943. VBIProMar31285_1692.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGcyaNOG04004.
HOGENOMHOG000266301.
KOK03536.
OMAMRLKGHR.
OrthoDBEOG6N94CP.

Enzyme and pathway databases

BioCycPMAR167555:GI3K-1690-MONOMER.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00227. RNase_P.
InterProIPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
[Graphical view]
PfamPF00825. Ribonuclease_P. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 1 hit.
TIGRFAMsTIGR00188. rnpA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRNPA_PROM1
AccessionPrimary (citable) accession number: A2C405
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 20, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families