A2C3W9 (SYGA_PROM1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycine--tRNA ligase alpha subunit
EC=6.1.1.14

Alternative name(s):
Glycyl-tRNA synthetase alpha subunit
Short name=GlyRS

Gene names

Name:	glyQ
Ordered Locus Names:	NATL1_16221

Organism

Prochlorococcus marinus (strain NATL1A) [Complete proteome] [HAMAP]

Taxonomic identifier

167555 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). HAMAP MF_00254
Subunit structure	Tetramer of two alpha and two beta subunits By similarity.
Subcellular location	Cytoplasm HAMAP MF_00254.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Glycine--tRNA ligase alpha subunit HAMAP MF_00254		PRO_1000047460

Sequences

	Sequence		Length	Mass (Da)
	A2C3W9 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 16EB988A4DB236AE	FASTA	290	33,425
	10 20 30 40 50 60 MYFQDIISNL NNFWSEKGCL LLQPYDLEKG AGTMSPHSFL RAIGPEPWAV AYPEPCRRPT 70 80 90 100 110 120 DGRYGDNPNR AQHYFQYQVL IKPSLDGIQE IYLSSLEALG ISAKEHDIRF VEDNWESPTL 130 140 150 160 170 180 GAWGVGWEVW LDGMEVTQFT YFQQCGGLDC KPVSIEITYG LERLAMYLQN VESIWDLSWN 190 200 210 220 230 240 KKTKYGDIWL PFEKGQCKYN FEESNSENLR KLFEIYEEEA HQLIAKKLPA PCLDYVLKCS 250 260 270 280 290 HTFNLLEARG VISVTERTKI IARIRSLARK VAEAWLEERG TLGFPLCAEN

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NATL1A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000553 Genomic DNA. Translation: ABM76179.1.
RefSeq	YP_001015444.1. NC_008819.1.
3D structure databases
ProteinModelPortal	A2C3W9.
SMR	A2C3W9. Positions 1-277.
ModBase	Search...
Protein-protein interaction databases
STRING	A2C3W9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4780063.
GenomeReviews	Gene locus NATL1_16221 in contig CP000553_GR.
KEGG	pme:NATL1_16221.
PATRIC	23020869. VBIProMar31285_1655.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0752.
HOGENOM	HBG285316.
OMA	CRRPTDG.
PhylomeDB	A2C3W9.
ProtClustDB	PRK09348.
Enzyme and pathway databases
BioCyc	PMAR167555:NATL1_16221-MONOMER.
Family and domain databases
HAMAP	MF_00254. Gly_tRNA_synth_alpha. [Tree]
InterPro	IPR006194. Gly-tRNA-synth_II_heterodimer. IPR002310. Gly-tRNA_synth_IIc_asu. [Graphical view]
KO	K01878.
Pfam	PF02091. tRNA-synt_2e. 1 hit. [Graphical view]
PRINTS	PR01044. TRNASYNTHGA.
TIGRFAMs	TIGR00388. GlyQ. 1 hit.
PROSITE	PS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYGA_PROM1

Accession

Primary (citable) accession number: A2C3W9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 20, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program