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A2C242

- SYL_PROM1

UniProt

A2C242 - SYL_PROM1

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Protein
Leucine--tRNA ligase
Gene
leuS, NATL1_09941
Organism
Prochlorococcus marinus (strain NATL1A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei627 – 6271ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR167555:GI3K-1016-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:NATL1_09941
OrganismiProchlorococcus marinus (strain NATL1A)
Taxonomic identifieri167555 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002592: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Leucine--tRNA ligaseUniRule annotation
PRO_0000334791Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167555.NATL1_09941.

Structurei

3D structure databases

ProteinModelPortaliA2C242.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 6111"HIGH" regionUniRule annotation
Add
BLAST
Motifi624 – 6285"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR024909. Cys-tRNA/MSH_ligase.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2C242-1 [UniParc]FASTAAdd to Basket

« Hide

MNNTTSDIND QRYEPREVEA YWQKEWANDD LYRTNTEVNK ENTFYALSMF    50
PYPSGSLHMG HVRNYVITDV LARYKRMKGL NVLHPMGWDS FGLPAENAAI 100
ERETSPSTWT DKNISQMKDQ LDRLGLSIDW SKEVTTCKED YYKWTQYIFN 150
QLHKNNLAYQ KKATVNWDPI DQTVLANEQV DAEGKSWRSG AKVEKKELNQ 200
WFLRITSFAE DLNKDLVTLN DWPDRVRVMQ KNWIGKSIGA EITFDIKNSD 250
QKITAFTTRI DTVYGVSYLV LASNHPLIDQ LISSNDIDKL NDFRQTQEKL 300
SDLERNSDTR QKLGMYLGVD AINPANNKEI PIWIGDYVIM EYGTGAVMGV 350
PAHDSRDYQF AKSYDLPIQY VIKPNIGEDE SYLNAEFVDK GVMINSDKFN 400
GIESDIAKTK ILEFGSNSNW AKPKITYKLR DWLISRQRYW GCPIPIINCK 450
KCGQVRVPDD DLPVVLPIDI KLTGKGKSPL TTKTEWINTC CPKCGTDAKR 500
ETDTMDTFMC SSWYFLRYIN PDNCEKPFLK SEIDKWLPVK QYVGGIEHAI 550
LHLLYSRFLT KALKRCGLIN IDEPFKKLLT QGMVQAVTFK NPNTNKYFSK 600
DQIKDIDNPK DPLTGENIEI IYEKMSKSKY NGVDPSVVID KYGADTARMF 650
ILFKAPPEKD LEWDDSDVEG QYRFIQRLWK FVINTFKLTN NNSRSNIEKE 700
KSKDEEALRL INIAIKEITD DLDNLQFNTA ISELMKVVNG LSLIVNYCSN 750
ETLNKVISIL VKITSPFSPH IAEELWKTIG NTQSIHLQSW PEFDAGAIEQ 800
DTFKLMIQIN GKVRGSINAS KNLSKENLED LAIKTEAAIK WMDGKEPKRI 850
IVVPNKLVNI VI 862
Length:862
Mass (Da):99,157
Last modified:February 20, 2007 - v1
Checksum:i51BCCCE7FB0922A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000553 Genomic DNA. Translation: ABM75552.1.
RefSeqiWP_011823678.1. NC_008819.1.
YP_001014817.1. NC_008819.1.

Genome annotation databases

EnsemblBacteriaiABM75552; ABM75552; NATL1_09941.
GeneIDi4780516.
KEGGipme:NATL1_09941.
PATRICi23019583. VBIProMar31285_1018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000553 Genomic DNA. Translation: ABM75552.1 .
RefSeqi WP_011823678.1. NC_008819.1.
YP_001014817.1. NC_008819.1.

3D structure databases

ProteinModelPortali A2C242.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167555.NATL1_09941.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM75552 ; ABM75552 ; NATL1_09941 .
GeneIDi 4780516.
KEGGi pme:NATL1_09941.
PATRICi 23019583. VBIProMar31285_1018.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PMAR167555:GI3K-1016-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR024909. Cys-tRNA/MSH_ligase.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL1A.

Entry informationi

Entry nameiSYL_PROM1
AccessioniPrimary (citable) accession number: A2C242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi