A2C241 (G6PI_PROM1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	NATL1_09931

Organism

Prochlorococcus marinus (strain NATL1A) [Complete proteome] [HAMAP]

Taxonomic identifier

167555 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 532	532	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000060397
Sites
	Active site	330	1	Proton donor By similarity
	Active site	359	1	By similarity
	Active site	461	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A2C241 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 5FD27170D553A1E6	FASTA	532	59,157
	10 20 30 40 50 60 MAITDIFQLN NNDKWERYCD LLYSDDSLGF WLDISRMDVA INDFEDFNEI YSKAFDALES 70 80 90 100 110 120 LENGSIANID EGRQVGHYWL RNPKVAPSAE ISDSITKEIQ NISKFGASIL NGEITNRHGK 130 140 150 160 170 180 KYTDVFWIGI GGSGLGPLLI KESFKRESIG LNLHFLDNVD PEGISHKLNS ILPNLDSTLF 190 200 210 220 230 240 VVVSKSGGTP EPLIGMEQAM KFVLDHSQNW SSRAIAITSK GSKLDVLANN ENWLDIFDLP 250 260 270 280 290 300 DWVGGRTSIT GAVGLLPAAL IGADINKFLN GASQMDALTR VKDIKNNPAA LLSLAWFKSG 310 320 330 340 350 360 NGKGLRDMVV LPYRDRLEVF SRYLQQLVME SLGKKFDRDE NQVNQGIAVY GNKGSTDQHA 370 380 390 400 410 420 YVQQLRDGID NFFVNFIEIL HDPLEIVEVK NKRPGDYLSG FLQGTRSALT EGGRQNLTIT 430 440 450 460 470 480 FKSFDESSLG ALIALFERAV SLYAELINVN AYNQPGVEAG KEAATKIIKL QKEIEELLDD 490 500 510 520 530 GKQRTLNEIN DALSSDSTES IYLILRKLSE NSDHYSMIGN QSNPDKLIIS KT

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NATL1A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000553 Genomic DNA. Translation: ABM75551.1.
RefSeq	YP_001014816.1. NC_008819.1.
3D structure databases
ProteinModelPortal	A2C241.
ModBase	Search...
Protein-protein interaction databases
STRING	A2C241.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4779187.
GenomeReviews	Gene locus NATL1_09931 in contig CP000553_GR.
KEGG	pme:NATL1_09931.
PATRIC	23019581. VBIProMar31285_1017.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG285902.
OMA	RTSITSA.
PhylomeDB	A2C241.
ProtClustDB	PRK14096.
Enzyme and pathway databases
BioCyc	PMAR167555:NATL1_09931-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. False negative. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_PROM1

Accession

Primary (citable) accession number: A2C241

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 20, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program