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A2C1E0 (AROB_PROM1) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:NATL1_07421
OrganismProchlorococcus marinus (strain NATL1A) [Complete proteome] [HAMAP]
Taxonomic identifier167555 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3683683-dehydroquinate synthase HAMAP MF_00110
PRO_1000094561

Sequences

Sequence LengthMass (Da)Tools
A2C1E0 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 31D44EF2808B9EB4

FASTA36840,601
        10         20         30         40         50         60 
MNKDNHHIKV SLTNNPYEIV IGKNSLESIG DELFNIGFRE GLKVLVVSNK EVSDHYGDCI 

        70         80         90        100        110        120 
IKSLIKSKFK PKLLIIKAGE DQKNQSSIDL IHNAAYEARL ERGSLMIALG GGVIGDMTGF 

       130        140        150        160        170        180 
AAATWLRGVN VVQIPTTLLA MVDASIGGKT GINHSKGKNL IGAFHQPRLV LIDPKTLISL 

       190        200        210        220        230        240 
PSREFKAGMA EIIKYGVISD LELFDLLERQ ENIADLSNIK EKLLLEIIKR SAKSKAEIVI 

       250        260        270        280        290        300 
KDEKESGVRA FLNYGHTFGH VIENLCGYGK WLHGEAVAMG MVAVGQLAVQ RGLWNEDNAK 

       310        320        330        340        350        360 
RQKRLIEKAG LPSNWPKLDI ESVLSSLQGD KKVKNGKVSF VMPLKIGDVK LFNNISNKEI 


RECLQKIS

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NATL1A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000553 Genomic DNA. Translation: ABM75300.1.
RefSeqYP_001014565.1. NC_008819.1.

3D structure databases

ProteinModelPortalA2C1E0.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2C1E0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4780370.
GenomeReviewsGene locus NATL1_07421 in contig CP000553_GR.
KEGGpme:NATL1_07421.
PATRIC23019053. VBIProMar31285_0756.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAWMRGVRV.
PhylomeDBA2C1E0.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycPMAR167555:NATL1_07421-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_PROM1
AccessionPrimary (citable) accession number: A2C1E0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 20, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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