A2C172 (COMB_PROM1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 2-phosphosulfolactate phosphatase
EC=3.1.3.71

Gene names

Name:	comB
Ordered Locus Names:	NATL1_06721

Organism

Prochlorococcus marinus (strain NATL1A) [Complete proteome] [HAMAP]

Taxonomic identifier

167555 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate. HAMAP MF_00490
Cofactor	Magnesium By similarity. HAMAP MF_00490
Sequence similarities	Belongs to the ComB family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme M biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-phosphosulfolactate phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Probable 2-phosphosulfolactate phosphatase HAMAP MF_00490		PRO_1000014466

Sequences

	Sequence		Length	Mass (Da)
	A2C172 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 93CBB8FCC8CC5CCF	FASTA	242	26,337
	10 20 30 40 50 60 MKLSYFYVAA DVPDGIIPES SVVIDVLRAT TTIAWALENG ADSVQVFADV DELKNQAKTF 70 80 90 100 110 120 DSKEKILVGE RGGKKLDGFD LGNSPLGVSS ESVKGKRVFM STTNGTRSLH RVRESKSLYT 130 140 150 160 170 180 MALPNRKAIA ERLKSDNPKE VWIVGSGWEG SYSLEDSLAA GALASLLMDQ LESVQIVNDE 190 200 210 220 230 240 LMASIALWKN WENDVEGCLR IASHGQRLAG IGNHDDDFAC CASLDNLSVI PKQIEMGVLR SN

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NATL1A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000553 Genomic DNA. Translation: ABM75232.1.
RefSeq	YP_001014497.1. NC_008819.1.
3D structure databases
ProteinModelPortal	A2C172.
ModBase	Search...
Protein-protein interaction databases
STRING	A2C172.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4779993.
GenomeReviews	Gene locus NATL1_06721 in contig CP000553_GR.
KEGG	pme:NATL1_06721.
PATRIC	23018907. VBIProMar31285_0684.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2045.
HOGENOM	HBG633644.
OMA	GWEGAYS.
PhylomeDB	A2C172.
ProtClustDB	PRK00886.
Enzyme and pathway databases
BioCyc	PMAR167555:NATL1_06721-MONOMER.
Family and domain databases
HAMAP	MF_00490. ComB. [Tree]
InterPro	IPR005238. 2-PSlactate_phosphatase. IPR022995. Pase_ComB. [Graphical view]
Gene3D	G3DSA:3.90.1560.10. 2-PSlactate_phosphatase. 1 hit.
KO	K05979.
Pfam	PF04029. 2-ph_phosp. 1 hit. [Graphical view]
SUPFAM	SSF142823. SSF142823. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COMB_PROM1

Accession

Primary (citable) accession number: A2C172

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 20, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program