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A2C126 (A2C126_PROM1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase HAMAP MF_00219
Short name=DHOase HAMAP MF_00219
EC=3.5.2.3 HAMAP MF_00219
Gene names
Name:pyrC HAMAP MF_00219
Ordered Locus Names:NATL1_06241
OrganismProchlorococcus marinus (strain NATL1A) [Complete proteome] [HAMAP] EMBL ABM75186.1
Taxonomic identifier167555 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP MF_00219 SAAS SAAS004721

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_00219 SAAS SAAS004721

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP MF_00219 SAAS SAAS004721

Subunit structure

Homodimer By similarity. HAMAP MF_00219 SAAS SAAS004721

Sequence similarities

Belongs to the DHOase family. Type 1 subfamily. HAMAP MF_00219

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding171Zinc 1 By similarity HAMAP MF_00219
Metal binding191Zinc 1 By similarity HAMAP MF_00219
Metal binding1031Zinc 1; via carbamate group By similarity HAMAP MF_00219
Metal binding1031Zinc 2; via carbamate group By similarity HAMAP MF_00219
Metal binding1401Zinc 2 By similarity HAMAP MF_00219
Metal binding1781Zinc 2 By similarity HAMAP MF_00219
Metal binding2511Zinc 1 By similarity HAMAP MF_00219

Amino acid modifications

Modified residue1031N6-carboxylysine By similarity HAMAP MF_00219

Sequences

Sequence LengthMass (Da)Tools
A2C126 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 5E996A2A5C86E1E9

FASTA35439,622
        10         20         30         40         50         60 
MIASVNQISL LKPDDWHLHL RDGKILKGVL SHTADVFCRA IIMPNLDPPI TTLSQAQEYK 

        70         80         90        100        110        120 
KRIIQSIPEG VSFTPLMTAY LTDDMPANVL ERGFREGVFH GAKLYPANVT TNSSYGVTDI 

       130        140        150        160        170        180 
SKVGNLFETM ERIGMPLLIH GEVTDFNVDV FDREAVFIER HLEPLLRTFS SLKVVLEHIT 

       190        200        210        220        230        240 
TIDAIDFVEN SEFDIAATIT PHHLHINRNA MFNGGLRSDF YCLPTAKREI HRIALRQAAT 

       250        260        270        280        290        300 
SGKTCFFLGT DSAPHTRRFK ESSCGCAGIF NAPFALESYL KVFEEENALD RFEAFSSING 

       310        320        330        340        350 
ATFYGLPLNT ERITLIRKDI SVPQMIDVGL DGNPNDFVKP FHSGETLSWA IKDV

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000553 Genomic DNA. Translation: ABM75186.1.
RefSeqYP_001014451.1. NC_008819.1.

3D structure databases

ProteinModelPortalA2C126.
SMRA2C126. Positions 8-352.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2C126.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4779514.
GenomeReviewsGene locus NATL1_06241 in contig CP000553_GR.
KEGGpme:NATL1_06241.
PATRIC23018809. VBIProMar31285_0636.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0418.
HOGENOMHBG628648.
OMACLPVAKR.
PhylomeDBA2C126.
ProtClustDBPRK05451.

Enzyme and pathway databases

BioCycPMAR167555:NATL1_06241-MONOMER.

Family and domain databases

HAMAPMF_00219. PyrC_type1.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsTIGR00856. PyrC_dimer. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA2C126_PROM1
AccessionPrimary (citable) accession number: A2C126
Entry history
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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