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A2C0U2

- GSA_PROM1

UniProt

A2C0U2 - GSA_PROM1

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene
hemL, NATL1_05401
Organism
Prochlorococcus marinus (strain NATL1A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-HAMAP
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Chlorophyll biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMAR167555:GI3K-557-MONOMER.
UniPathwayiUPA00251; UER00317.
UPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:NATL1_05401
OrganismiProchlorococcus marinus (strain NATL1A)
Taxonomic identifieri167555 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002592: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotationPRO_1000201029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi167555.NATL1_05401.

Structurei

3D structure databases

ProteinModelPortaliA2C0U2.
SMRiA2C0U2. Positions 3-427.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2C0U2-1 [UniParc]FASTAAdd to Basket

« Hide

MNTKRSEEIF GAAKNLMPGG VSSPVRAFKS VEGDPIVFDR VKGPYAWDVD    50
GNRYIDYVGS WGPAICGHAH PEVIAALQET LEKGTSFGAP CVLENQLAEM 100
VIDAVPSVEM VRFVNSGTEA CMAVLRLMRA FTGRDKVIKF EGCYHGHADM 150
FLVKAGSGVA TLGLPDSPGV PRSTTANTLT APYNDLEAVK ELFAENPDAI 200
SGVILEPVVG NAGFITPEPG FLEGLREVTQ ENGALLVFDE VMTGFRISYG 250
GAQERFGVTP DLTTMGKVIG GGLPVGAYGG RKEIMSMVSP SGPMYQAGTL 300
SGNPLAMTAG IKTLELLKQE GTYEKLEALT KKLLDGILTA AKESNIPIYG 350
QSISAMFGFY LCEGPVRNFE EAKSSDTELF SKIHRLMLQK GVYLAPSAFE 400
AGFTSLAHSE DDINATIKAF QEIFSEIS 428
Length:428
Mass (Da):45,823
Last modified:February 20, 2007 - v1
Checksum:i5186802BEC729C86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000553 Genomic DNA. Translation: ABM75102.1.
RefSeqiWP_011823279.1. NC_008819.1.
YP_001014367.1. NC_008819.1.

Genome annotation databases

EnsemblBacteriaiABM75102; ABM75102; NATL1_05401.
GeneIDi4780455.
KEGGipme:NATL1_05401.
PATRICi23018637. VBIProMar31285_0550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000553 Genomic DNA. Translation: ABM75102.1 .
RefSeqi WP_011823279.1. NC_008819.1.
YP_001014367.1. NC_008819.1.

3D structure databases

ProteinModelPortali A2C0U2.
SMRi A2C0U2. Positions 3-427.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167555.NATL1_05401.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM75102 ; ABM75102 ; NATL1_05401 .
GeneIDi 4780455.
KEGGi pme:NATL1_05401.
PATRICi 23018637. VBIProMar31285_0550.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
UPA00668 .
BioCyci PMAR167555:GI3K-557-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL1A.

Entry informationi

Entry nameiGSA_PROM1
AccessioniPrimary (citable) accession number: A2C0U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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