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A2C098

- PUR9_PROM1

UniProt

A2C098 - PUR9_PROM1

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, NATL1_03441
Organism
Prochlorococcus marinus (strain NATL1A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPMAR167555:GI3K-350-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:NATL1_03441
OrganismiProchlorococcus marinus (strain NATL1A)
Taxonomic identifieri167555 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018926Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167555.NATL1_03441.

Structurei

3D structure databases

ProteinModelPortaliA2C098.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A2C098-1 [UniParc]FASTAAdd to Basket

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MSPIALLSVS DKTGLIPLAK ALVNELGFKI ISSGGTAKLI ESENLPVTRV    50
ADYTGFPEIL GGRVKTLNPK IHGGILARRD KQSHLDDLDK QNINPIDLVV 100
VNLYPFVKTI SKENVSWEEA IENIDIGGPT MIRAAAKNHQ DVLVVTDPSQ 150
YSNLIDAYKS KKITPELRKK YSQQAFEHTA TYDLTISNWI ANQSSSKKVS 200
WLQSLPLKQE LRYGENPHQK ASWYGEPEKG WSGANQLQGK ELSTNNLLDL 250
EAALSTLREF GYKNTISNPS YQKAAVVIKH TNPCGVAIGD SPSSALKRAL 300
DGDRVSAFGG IIAINCPVDE AAAKEIENIF IECVVAPYFD ETAKEILSKK 350
KNLRLLELKA ESVQKADKNH IRSILGGLLI QDLDEPSIDQ KKWKSVTELI 400
PTDEEMNDLS FAWKIVKHIR SNAIAVASNQ QSLGIGAGQM NRVGSAKLAL 450
EAAGTKSKGA VLASDGFFPF DDTVKMASDY GISSIIQPGG SIRDEDSIKA 500
CNELGIKMIL TGKRHFLH 518
Length:518
Mass (Da):56,646
Last modified:February 20, 2007 - v1
Checksum:i89066F355F623F81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000553 Genomic DNA. Translation: ABM74908.1.
RefSeqiYP_001014173.1. NC_008819.1.

Genome annotation databases

EnsemblBacteriaiABM74908; ABM74908; NATL1_03441.
GeneIDi4779059.
KEGGipme:NATL1_03441.
PATRICi23018215. VBIProMar31285_0351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000553 Genomic DNA. Translation: ABM74908.1 .
RefSeqi YP_001014173.1. NC_008819.1.

3D structure databases

ProteinModelPortali A2C098.
ModBasei Search...

Protein-protein interaction databases

STRINGi 167555.NATL1_03441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM74908 ; ABM74908 ; NATL1_03441 .
GeneIDi 4779059.
KEGGi pme:NATL1_03441.
PATRICi 23018215. VBIProMar31285_0351.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PMAR167555:GI3K-350-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL1A.

Entry informationi

Entry nameiPUR9_PROM1
AccessioniPrimary (citable) accession number: A2C098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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