pyrB

Functionⁱ

Catalytic activityⁱ

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayⁱ: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA)
Aspartate carbamoyltransferase (pyrB)
Dihydroorotase (pyrC)

This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functionⁱ

amino acid binding Source: InterPro
aspartate carbamoyltransferase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
cellular amino acid metabolic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Transferase
Biological process	Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayⁱ	UPA00070; UER00116.

UniPathwayⁱ

UPA00070; UER00116.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation) Alternative name(s): Aspartate transcarbamylaseUniRule annotation Short name: ATCaseUniRule annotation
Gene namesⁱ	Name:pyrBUniRule annotation Ordered Locus Names:NATL1_03121
Organismⁱ	Prochlorococcus marinus (strain NATL1A)
Taxonomic identifierⁱ	167555 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Cyanobacteria › Synechococcales › Prochloraceae › Prochlorococcus › Prochlorococcus marinus
Proteomesⁱ	UP000002592 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000301605	1 – 339	Aspartate carbamoyltransferaseAdd BLAST		339

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	167555.NATL1_03121.

STRINGⁱ

167555.NATL1_03121.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A2C066.
SMRⁱ	A2C066.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105CXT. Bacteria. COG0540. LUCA.
HOGENOMⁱ	HOG000022685.
KEGG Orthology (KO) More...KOⁱ	K00609.
OMAⁱ	WCDVANM.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00PQ.

Family and domain databases

Gene3Dⁱ	3.40.50.1370. 2 hits.
HAMAPⁱ	MF_00001. Asp_carb_tr. 1 hit.
InterProⁱ	View protein in InterPro IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR002082. Asp_carbamoyltransf. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
PANTHERⁱ	PTHR11405:SF53. PTHR11405:SF53. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit.
PRINTSⁱ	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAMⁱ	SSF53671. SSF53671. 1 hit.
TIGRFAMsⁱ	TIGR00670. asp_carb_tr. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00097. CARBAMOYLTRANSFERASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A2C066-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNNWKHNHVL DLSTFSLEDY KTVLELTTRF KDVHKSSSKK LPALHGRLIA 
        60         70         80         90        100
NLFFEPSTRT RTSFELAAKR LSADVQNFSV SSSSLSKGET PLDTILTYIS 
       110        120        130        140        150
MGADILVIRH ESTNVPAELA NYVDINNINT SILNAGDGFH SHPSQGLLDL 
       160        170        180        190        200
FTLATFFNPN EPSTNSLLNK KITIVGDILH SRVARSNLWA LTACGAEVTL 
       210        220        230        240        250
CGPPSLLPEE FIDFVQNPRL GQNFDPINKR GSVFIKRSLK DALKNSDAVM 
       260        270        280        290        300
TLRLQKERMK QNMLKDLDSY YAQYGITHES LKWCEKKVPV LHPGPVNRGV 
       310        320        330 
EISNRLVEDN SINLISKQVE NGIPTRMALL YLLGLNKKD

Length:339

Mass (Da):37,947

Last modified:February 20, 2007 - v1

Checksum:ⁱCC29BB14BDF7FA99

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000553 Genomic DNA. Translation: ABM74876.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011823086.1. NC_008819.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABM74876; ABM74876; NATL1_03121.
KEGGⁱ	pme:NATL1_03121.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000553 Genomic DNA. Translation: ABM74876.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011823086.1. NC_008819.1.

3D structure databases

ProteinModelPortalⁱ	A2C066.
SMRⁱ	A2C066.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	167555.NATL1_03121.

STRINGⁱ

167555.NATL1_03121.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABM74876; ABM74876; NATL1_03121.
KEGGⁱ	pme:NATL1_03121.

Phylogenomic databases

eggNOGⁱ	ENOG4105CXT. Bacteria. COG0540. LUCA.
HOGENOMⁱ	HOG000022685.
KEGG Orthology (KO) More...KOⁱ	K00609.
OMAⁱ	WCDVANM.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00PQ.

Enzyme and pathway databases

UniPathwayⁱ	UPA00070; UER00116.

UniPathwayⁱ

UPA00070; UER00116.

Family and domain databases

Gene3Dⁱ	3.40.50.1370. 2 hits.
HAMAPⁱ	MF_00001. Asp_carb_tr. 1 hit.
InterProⁱ	View protein in InterPro IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR002082. Asp_carbamoyltransf. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
PANTHERⁱ	PTHR11405:SF53. PTHR11405:SF53. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit.
PRINTSⁱ	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAMⁱ	SSF53671. SSF53671. 1 hit.
TIGRFAMsⁱ	TIGR00670. asp_carb_tr. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00097. CARBAMOYLTRANSFERASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PYRB_PROM1
Accessionⁱ	A2C066Primary (citable) accession number: A2C066
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	February 20, 2007
	Last modified:	June 7, 2017
	This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB - A2C066 (PYRB_PROM1)

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Aspartate carbamoyltransferase

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: UMP biosynthesis via de novo pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

PTM / Processingⁱ

Molecule processing

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A2C066 (PYRB_PROM1)

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Aspartate carbamoyltransferase

pyrB

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: UMP biosynthesis via de novo pathway

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: UMP biosynthesis via de novo pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ