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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Prochlorococcus marinus (strain NATL1A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciPMAR167555:G1G7Z-288-MONOMER
UniPathwayiUPA00070; UER00116

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:NATL1_03121
OrganismiProchlorococcus marinus (strain NATL1A)
Taxonomic identifieri167555 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002592 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003016051 – 339Aspartate carbamoyltransferaseAdd BLAST339

Interactioni

Protein-protein interaction databases

STRINGi167555.NATL1_03121

Structurei

3D structure databases

ProteinModelPortaliA2C066
SMRiA2C066
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXT Bacteria
COG0540 LUCA
HOGENOMiHOG000022685
KOiK00609
OMAiWCDVANM
OrthoDBiPOG091H00PQ

Family and domain databases

Gene3Di3.40.50.13703 hits
HAMAPiMF_00001 Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16 PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

A2C066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNWKHNHVL DLSTFSLEDY KTVLELTTRF KDVHKSSSKK LPALHGRLIA
60 70 80 90 100
NLFFEPSTRT RTSFELAAKR LSADVQNFSV SSSSLSKGET PLDTILTYIS
110 120 130 140 150
MGADILVIRH ESTNVPAELA NYVDINNINT SILNAGDGFH SHPSQGLLDL
160 170 180 190 200
FTLATFFNPN EPSTNSLLNK KITIVGDILH SRVARSNLWA LTACGAEVTL
210 220 230 240 250
CGPPSLLPEE FIDFVQNPRL GQNFDPINKR GSVFIKRSLK DALKNSDAVM
260 270 280 290 300
TLRLQKERMK QNMLKDLDSY YAQYGITHES LKWCEKKVPV LHPGPVNRGV
310 320 330
EISNRLVEDN SINLISKQVE NGIPTRMALL YLLGLNKKD
Length:339
Mass (Da):37,947
Last modified:February 20, 2007 - v1
Checksum:iCC29BB14BDF7FA99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000553 Genomic DNA Translation: ABM74876.1
RefSeqiWP_011823086.1, NC_008819.1

Genome annotation databases

EnsemblBacteriaiABM74876; ABM74876; NATL1_03121
KEGGipme:NATL1_03121

Similar proteinsi

Entry informationi

Entry nameiPYRB_PROM1
AccessioniPrimary (citable) accession number: A2C066
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 20, 2007
Last modified: February 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome