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UniProtKB - A2C066 (PYRB_PROM1)

UniProt

A2C066 - PYRB_PROM1

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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Prochlorococcus marinus (strain NATL1A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase (glutamine-hydrolyzing) (carB), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciPMAR167555:GI3K-316-MONOMER.
UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:NATL1_03121
OrganismiProchlorococcus marinus (strain NATL1A)
Taxonomic identifieri167555 [NCBI]
Taxonomic lineageiBacteria › Cyanobacteria › Prochlorales › Prochlorococcaceae › Prochlorococcus ›
Proteomesi
  • UP000002592 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Aspartate carbamoyltransferasePRO_0000301605Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167555.NATL1_03121.

Structurei

3D structure databases

ProteinModelPortaliA2C066.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXT. Bacteria.
COG0540. LUCA.
HOGENOMiHOG000022685.
KOiK00609.
OMAiMHPGPMV.
OrthoDBiPOG091H00PQ.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2C066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNWKHNHVL DLSTFSLEDY KTVLELTTRF KDVHKSSSKK LPALHGRLIA 
        60         70         80         90        100
NLFFEPSTRT RTSFELAAKR LSADVQNFSV SSSSLSKGET PLDTILTYIS 
       110        120        130        140        150
MGADILVIRH ESTNVPAELA NYVDINNINT SILNAGDGFH SHPSQGLLDL 
       160        170        180        190        200
FTLATFFNPN EPSTNSLLNK KITIVGDILH SRVARSNLWA LTACGAEVTL 
       210        220        230        240        250
CGPPSLLPEE FIDFVQNPRL GQNFDPINKR GSVFIKRSLK DALKNSDAVM 
       260        270        280        290        300
TLRLQKERMK QNMLKDLDSY YAQYGITHES LKWCEKKVPV LHPGPVNRGV 
       310        320        330 
EISNRLVEDN SINLISKQVE NGIPTRMALL YLLGLNKKD
Length:339
Mass (Da):37,947
Last modified:February 20, 2007 - v1
Checksum:iCC29BB14BDF7FA99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000553 Genomic DNA. Translation: ABM74876.1.
RefSeqiWP_011823086.1. NC_008819.1.

Genome annotation databases

EnsemblBacteriaiABM74876; ABM74876; NATL1_03121.
KEGGipme:NATL1_03121.
PATRICi23018145. VBIProMar31285_0318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000553 Genomic DNA. Translation: ABM74876.1.
RefSeqiWP_011823086.1. NC_008819.1.

3D structure databases

ProteinModelPortaliA2C066.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi167555.NATL1_03121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM74876; ABM74876; NATL1_03121.
KEGGipme:NATL1_03121.
PATRICi23018145. VBIProMar31285_0318.

Phylogenomic databases

eggNOGiENOG4105CXT. Bacteria.
COG0540. LUCA.
HOGENOMiHOG000022685.
KOiK00609.
OMAiMHPGPMV.
OrthoDBiPOG091H00PQ.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00116.
BioCyciPMAR167555:GI3K-316-MONOMER.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYRB_PROM1
AccessioniPrimary (citable) accession number: A2C066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.