UniProtKB - A2C066 (PYRB_PROM1)
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Protein
Aspartate carbamoyltransferase
Gene
pyrB
Organism
Prochlorococcus marinus (strain NATL1A)
Status
Functioni
Catalytic activityi
Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation
: UMP biosynthesis via de novo pathway Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA)
- Aspartate carbamoyltransferase (pyrB)
- Dihydroorotase (pyrC)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.
GO - Molecular functioni
- amino acid binding Source: InterPro
- aspartate carbamoyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
- 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
- cellular amino acid metabolic process Source: InterPro
Keywordsi
Molecular function | Transferase |
Biological process | Pyrimidine biosynthesis |
Enzyme and pathway databases
BioCyci | PMAR167555:G1G7Z-288-MONOMER |
UniPathwayi | UPA00070; UER00116 |
Names & Taxonomyi
Protein namesi | Recommended name: Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)Alternative name(s): Aspartate transcarbamylaseUniRule annotation Short name: ATCaseUniRule annotation |
Gene namesi | Name:pyrBUniRule annotation Ordered Locus Names:NATL1_03121 |
Organismi | Prochlorococcus marinus (strain NATL1A) |
Taxonomic identifieri | 167555 [NCBI] |
Taxonomic lineagei | Bacteria › Cyanobacteria › Synechococcales › Prochloraceae › Prochlorococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000301605 | 1 – 339 | Aspartate carbamoyltransferaseAdd BLAST | 339 |
Structurei
3D structure databases
ProteinModelPortali | A2C066 |
SMRi | A2C066 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the ATCase/OTCase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105CXT Bacteria COG0540 LUCA |
HOGENOMi | HOG000022685 |
KOi | K00609 |
OMAi | WCDVANM |
OrthoDBi | POG091H00PQ |
Family and domain databases
Gene3Di | 3.40.50.13703 hits |
HAMAPi | MF_00001 Asp_carb_tr, 1 hit |
InterProi | View protein in InterPro IPR006132 Asp/Orn_carbamoyltranf_P-bd IPR006130 Asp/Orn_carbamoylTrfase IPR036901 Asp/Orn_carbamoylTrfase_sf IPR002082 Asp_carbamoyltransf IPR006131 Asp_carbamoyltransf_Asp/Orn-bd |
PANTHERi | PTHR11405:SF16 PTHR11405:SF16, 1 hit |
Pfami | View protein in Pfam PF00185 OTCace, 1 hit PF02729 OTCace_N, 1 hit |
PRINTSi | PR00100 AOTCASE PR00101 ATCASE |
SUPFAMi | SSF53671 SSF53671, 1 hit |
TIGRFAMsi | TIGR00670 asp_carb_tr, 1 hit |
PROSITEi | View protein in PROSITE PS00097 CARBAMOYLTRANSFERASE, 1 hit |
i Sequence
Sequence statusi: Complete.
A2C066-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNWKHNHVL DLSTFSLEDY KTVLELTTRF KDVHKSSSKK LPALHGRLIA
60 70 80 90 100
NLFFEPSTRT RTSFELAAKR LSADVQNFSV SSSSLSKGET PLDTILTYIS
110 120 130 140 150
MGADILVIRH ESTNVPAELA NYVDINNINT SILNAGDGFH SHPSQGLLDL
160 170 180 190 200
FTLATFFNPN EPSTNSLLNK KITIVGDILH SRVARSNLWA LTACGAEVTL
210 220 230 240 250
CGPPSLLPEE FIDFVQNPRL GQNFDPINKR GSVFIKRSLK DALKNSDAVM
260 270 280 290 300
TLRLQKERMK QNMLKDLDSY YAQYGITHES LKWCEKKVPV LHPGPVNRGV
310 320 330
EISNRLVEDN SINLISKQVE NGIPTRMALL YLLGLNKKD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000553 Genomic DNA Translation: ABM74876.1 |
RefSeqi | WP_011823086.1, NC_008819.1 |
Genome annotation databases
EnsemblBacteriai | ABM74876; ABM74876; NATL1_03121 |
KEGGi | pme:NATL1_03121 |
Similar proteinsi
Entry informationi
Entry namei | PYRB_PROM1 | |
Accessioni | A2C066Primary (citable) accession number: A2C066 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 28, 2018 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |