A2C066 (PYRB_PROM1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	NATL1_03121

Organism

Prochlorococcus marinus (strain NATL1A) [Complete proteome] [HAMAP]

Taxonomic identifier

167555 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Prochlorales › Prochlorococcaceae › Prochlorococcus › Prochlorococcus marinus

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP-Rule MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP-Rule MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' UMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway 'de novo' pyrimidine nucleobase biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Aspartate carbamoyltransferase HAMAP-Rule MF_00001		PRO_0000301605

Sequences

	Sequence		Length	Mass (Da)
	A2C066 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: CC29BB14BDF7FA99	FASTA	339	37,947
	10 20 30 40 50 60 MNNWKHNHVL DLSTFSLEDY KTVLELTTRF KDVHKSSSKK LPALHGRLIA NLFFEPSTRT 70 80 90 100 110 120 RTSFELAAKR LSADVQNFSV SSSSLSKGET PLDTILTYIS MGADILVIRH ESTNVPAELA 130 140 150 160 170 180 NYVDINNINT SILNAGDGFH SHPSQGLLDL FTLATFFNPN EPSTNSLLNK KITIVGDILH 190 200 210 220 230 240 SRVARSNLWA LTACGAEVTL CGPPSLLPEE FIDFVQNPRL GQNFDPINKR GSVFIKRSLK 250 260 270 280 290 300 DALKNSDAVM TLRLQKERMK QNMLKDLDSY YAQYGITHES LKWCEKKVPV LHPGPVNRGV 310 320 330 EISNRLVEDN SINLISKQVE NGIPTRMALL YLLGLNKKD

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NATL1A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000553 Genomic DNA. Translation: ABM74876.1.
RefSeq	YP_001014141.1. NC_008819.1.
3D structure databases
ProteinModelPortal	A2C066.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	167555.NATL1_03121.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABM74876; ABM74876; NATL1_03121.
GeneID	4780421.
KEGG	pme:NATL1_03121.
PATRIC	23018145. VBIProMar31285_0318.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HOG000022685.
KO	K00609.
OMA	MTLNAMR.
OrthoDB	EOG61KBJZ.
Enzyme and pathway databases
BioCyc	PMAR167555:GI3K-316-MONOMER.
UniPathway	UPA00070; UER00116.
Family and domain databases
Gene3D	3.40.50.1370. 2 hits.
HAMAP	MF_00001. Asp_carb_tr.
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR002082. Asp_carbamoyltransf. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. SSF53671. 1 hit.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_PROM1

Accession

Primary (citable) accession number: A2C066

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	February 20, 2007
Last modified:	May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program