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A2C058 (AROC_PROM1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chorismate synthase

EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:NATL1_03041
OrganismProchlorococcus marinus (strain NATL1A) [Complete proteome] [HAMAP]
Taxonomic identifier167555 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP-Rule MF_00300

Cofactor

Reduced flavin By similarity. HAMAP-Rule MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP-Rule MF_00300

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

chorismate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionchorismate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Chorismate synthase HAMAP-Rule MF_00300
PRO_1000022522

Sequences

Sequence LengthMass (Da)Tools
A2C058 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: A98EB58BE0EE5EBA

FASTA36138,830
        10         20         30         40         50         60 
MGSSFGKLFT ISTFGESHGG GVGVIIDGCP PRLELDINEI QNDLNRRRPG QSKITTPRNE 

        70         80         90        100        110        120 
SDEVEILSGL LGNKTLGTPI AMVVRNKDHR PKDYSEIKKT FRPSHADATY QKKYGIQASS 

       130        140        150        160        170        180 
GGGRASARET IGRVAAGSVA KQLLTKFAKT EILAWVKRIH DIEAEIHPSE VTFDEIEKNI 

       190        200        210        220        230        240 
VRCPNQSAAD LMIQRVEAFG KEGDSCGGVI ECVVRNPPIG LGMPVFDKLE ADLAKALMSL 

       250        260        270        280        290        300 
PATKGFEVGS GFGGTYLKGS EHNDPFLPSD SNQLKTATNN SGGIQGGISN GEDIVLRVGF 

       310        320        330        340        350        360 
KPTATIRKSQ KTIDEDGNAI TLKATGRHDP CVLPRAVPMV EAMVALVLAD HLLRQRGQCT 


D 

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NATL1A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000553 Genomic DNA. Translation: ABM74868.1.
RefSeqYP_001014133.1. NC_008819.1.

3D structure databases

ProteinModelPortalA2C058.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167555.NATL1_03041.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM74868; ABM74868; NATL1_03041.
GeneID4780216.
KEGGpme:NATL1_03041.
PATRIC23018129. VBIProMar31285_0310.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0082.
HOGENOMHOG000060335.
KOK01736.
OMARHDPCIA.
OrthoDBEOG6WDSHT.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycPMAR167555:GI3K-308-MONOMER.
UniPathwayUPA00053; UER00090.

Family and domain databases

Gene3D3.60.150.10. 1 hit.
HAMAPMF_00300. Chorismate_synth.
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
PANTHERPTHR21085. PTHR21085. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. SSF103263. 1 hit.
TIGRFAMsTIGR00033. aroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_PROM1
AccessionPrimary (citable) accession number: A2C058
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways