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A2C007

- A2C007_PROM1

UniProt

A2C007 - A2C007_PROM1

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Protein
Glutathione synthetase
Gene
gshB, NATL1_02531
Organism
Prochlorococcus marinus (strain NATL1A)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi275 – 2751Magnesium or manganese By similarityUniRule annotation
Metal bindingi277 – 2771Magnesium or manganese By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi146 – 20257ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutathione synthase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Glutathione biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR167555:GI3K-257-MONOMER.
    UniPathwayiUPA00142; UER00210.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione synthetaseUniRule annotation (EC:6.3.2.3UniRule annotation)
    Alternative name(s):
    GSH synthetase
    Glutathione synthase
    Gene namesi
    Name:gshBUniRule annotationImported
    Ordered Locus Names:NATL1_02531Imported
    OrganismiProchlorococcus marinus (strain NATL1A)Imported
    Taxonomic identifieri167555 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002592: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: InterPro
    Complete GO annotation...

    Interactioni

    Protein-protein interaction databases

    STRINGi167555.NATL1_02531.

    Structurei

    3D structure databases

    ProteinModelPortaliA2C007.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini120 – 304185ATP-grasp By similarityUniRule annotation
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the prokaryotic GSH synthase family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0189.
    HOGENOMiHOG000265022.
    KOiK01920.
    OMAiDWKIARA.
    OrthoDBiEOG6WMHWB.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPiMF_00162. GSH_S.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006284. Glut_synth_pro.
    IPR004218. GSHS_ATP-bd.
    IPR004215. GSHS_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PfamiPF02955. GSH-S_ATP. 1 hit.
    PF02951. GSH-S_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01380. glut_syn. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2C007-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQLFVLDPI ENINPKKDSS AALMQAASRA NIDVWICTPS DLQARGDDAW    50
    VVSNKVNCEP WINVQSPRSL PLRDFSCIWM RKDPPVDEAF LYATHLLEVA 100
    ERDGVNVINK PASLRAWNEK LGALRFSDLM APTLVASRVE QLITFAKEYG 150
    EVVLKPLGGK GGQGVIRIAK DAPGLEALLE LVTSQEHLPV MMQQFLPEVI 200
    NGDKRILLVN GEPLGAINRR PKEGDFRSNL ALGGKAETTK LTPKEIEICN 250
    QIKPALQEEG LFFVGIDVIG GMLSEINVTS PTGIREVENL MNVPLADQVI 300
    DYLIDHLNN 309
    Length:309
    Mass (Da):34,110
    Last modified:February 20, 2007 - v1
    Checksum:i67AF4DC3677C9B6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000553 Genomic DNA. Translation: ABM74817.1.
    RefSeqiWP_011823037.1. NC_008819.1.
    YP_001014082.1. NC_008819.1.

    Genome annotation databases

    EnsemblBacteriaiABM74817; ABM74817; NATL1_02531.
    GeneIDi4779433.
    KEGGipme:NATL1_02531.
    PATRICi23018031. VBIProMar31285_0261.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000553 Genomic DNA. Translation: ABM74817.1 .
    RefSeqi WP_011823037.1. NC_008819.1.
    YP_001014082.1. NC_008819.1.

    3D structure databases

    ProteinModelPortali A2C007.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 167555.NATL1_02531.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM74817 ; ABM74817 ; NATL1_02531 .
    GeneIDi 4779433.
    KEGGi pme:NATL1_02531.
    PATRICi 23018031. VBIProMar31285_0261.

    Phylogenomic databases

    eggNOGi COG0189.
    HOGENOMi HOG000265022.
    KOi K01920.
    OMAi DWKIARA.
    OrthoDBi EOG6WMHWB.

    Enzyme and pathway databases

    UniPathwayi UPA00142 ; UER00210 .
    BioCyci PMAR167555:GI3K-257-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPi MF_00162. GSH_S.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006284. Glut_synth_pro.
    IPR004218. GSHS_ATP-bd.
    IPR004215. GSHS_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    Pfami PF02955. GSH-S_ATP. 1 hit.
    PF02951. GSH-S_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01380. glut_syn. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NATL1A.

    Entry informationi

    Entry nameiA2C007_PROM1
    AccessioniPrimary (citable) accession number: A2C007
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: September 3, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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