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A2C007 (A2C007_PROM1) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutathione synthetase HAMAP-Rule MF_00162

EC=6.3.2.3 HAMAP-Rule MF_00162
Alternative name(s):
GSH synthetase HAMAP-Rule MF_00162
Glutathione synthase HAMAP-Rule MF_00162
Gene names
Name:gshB HAMAP-Rule MF_00162 EMBL ABM74817.1
Ordered Locus Names:NATL1_02531 EMBL ABM74817.1
OrganismProchlorococcus marinus (strain NATL1A) [Complete proteome] [HAMAP] EMBL ABM74817.1
Taxonomic identifier167555 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione. HAMAP-Rule MF_00162

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. HAMAP-Rule MF_00162

Pathway

Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. HAMAP-Rule MF_00162

Sequence similarities

Belongs to the prokaryotic GSH synthase family. HAMAP-Rule MF_00162

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00162

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain120 – 304185ATP-grasp By similarity HAMAP-Rule MF_00162
Nucleotide binding146 – 20257ATP By similarity HAMAP-Rule MF_00162

Sites

Metal binding2751Magnesium or manganese By similarity HAMAP-Rule MF_00162
Metal binding2771Magnesium or manganese By similarity HAMAP-Rule MF_00162

Sequences

Sequence LengthMass (Da)Tools
A2C007 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 67AF4DC3677C9B6D

FASTA30934,110
        10         20         30         40         50         60 
MKQLFVLDPI ENINPKKDSS AALMQAASRA NIDVWICTPS DLQARGDDAW VVSNKVNCEP 

        70         80         90        100        110        120 
WINVQSPRSL PLRDFSCIWM RKDPPVDEAF LYATHLLEVA ERDGVNVINK PASLRAWNEK 

       130        140        150        160        170        180 
LGALRFSDLM APTLVASRVE QLITFAKEYG EVVLKPLGGK GGQGVIRIAK DAPGLEALLE 

       190        200        210        220        230        240 
LVTSQEHLPV MMQQFLPEVI NGDKRILLVN GEPLGAINRR PKEGDFRSNL ALGGKAETTK 

       250        260        270        280        290        300 
LTPKEIEICN QIKPALQEEG LFFVGIDVIG GMLSEINVTS PTGIREVENL MNVPLADQVI 


DYLIDHLNN 

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NATL1A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000553 Genomic DNA. Translation: ABM74817.1.
RefSeqYP_001014082.1. NC_008819.1.

3D structure databases

ProteinModelPortalA2C007.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167555.NATL1_02531.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM74817; ABM74817; NATL1_02531.
GeneID4779433.
KEGGpme:NATL1_02531.
PATRIC23018031. VBIProMar31285_0261.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0189.
HOGENOMHOG000265022.
KOK01920.
OMAPTCFQEI.
OrthoDBEOG6WMHWB.
ProtClustDBPRK05246.

Enzyme and pathway databases

BioCycPMAR167555:GI3K-257-MONOMER.
UniPathwayUPA00142; UER00210.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00162. GSH_S.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006284. Glut_synth_pro.
IPR004218. GSHS_ATP-bd.
IPR004215. GSHS_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamPF02955. GSH-S_ATP. 1 hit.
PF02951. GSH-S_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01380. glut_syn. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA2C007_PROM1
AccessionPrimary (citable) accession number: A2C007
Entry history
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)