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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Prochlorococcus marinus (strain NATL1A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPMAR167555:GI3K-35-MONOMER.
UniPathwayiUPA00148; UER00227.

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:NATL1_00341
OrganismiProchlorococcus marinus (strain NATL1A)
Taxonomic identifieri167555 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
Proteomesi
  • UP000002592 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Cobalt-precorrin-5B C(1)-methyltransferasePRO_1000046871Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167555.NATL1_00341.

Structurei

3D structure databases

ProteinModelPortaliA2BZD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107VQD. Bacteria.
COG1903. LUCA.
HOGENOMiHOG000232408.
KOiK02188.
OMAiLGYHGKL.
OrthoDBiPOG091H02QJ.

Family and domain databases

HAMAPiMF_00787. CbiD. 1 hit.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.

Sequencei

Sequence statusi: Complete.

A2BZD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQFTLPVWV VAAAKSATNI LIGNKFRDKE RIDLPNKEES ISVPISSSAL
60 70 80 90 100
LDNGKRSLAV SHCQSGLPLD ITRGVEIWAY IQLSKGSSQS KGKVQNGFPD
110 120 130 140 150
WLDFHAGCGV GKFQSSGQPC ISQFARDLLC INLYPLVPKG NSIKVEIILP
160 170 180 190 200
EGKDRASKTS NEAFGVVDGL SLIGTQAEVQ ISASPDQLKN CKEILYHKCS
210 220 230 240 250
EAKFDGCLTF VIGENGMDLA MKYGLPANQI IKTGNWLGPL LVAAAENGVK
260 270 280 290 300
KLLLFGYHGK LIKLSGGVFH THHHLADGRI EILTSLAFRE GISFDLIELI
310 320 330 340 350
SKSTSVENAL LTLEVSNPDA VSLIWSRMAK EIEIKSRSYV NRYLSSSMEI
360 370 380
GSVLFDRKRQ MRWAGLEGLK QINSLGLILK R
Length:381
Mass (Da):41,729
Last modified:February 20, 2007 - v1
Checksum:i447ED318C4FC2679
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000553 Genomic DNA. Translation: ABM74598.1.
RefSeqiWP_011822836.1. NC_008819.1.

Genome annotation databases

EnsemblBacteriaiABM74598; ABM74598; NATL1_00341.
KEGGipme:NATL1_00341.
PATRICi23017575. VBIProMar31285_0035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000553 Genomic DNA. Translation: ABM74598.1.
RefSeqiWP_011822836.1. NC_008819.1.

3D structure databases

ProteinModelPortaliA2BZD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi167555.NATL1_00341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM74598; ABM74598; NATL1_00341.
KEGGipme:NATL1_00341.
PATRICi23017575. VBIProMar31285_0035.

Phylogenomic databases

eggNOGiENOG4107VQD. Bacteria.
COG1903. LUCA.
HOGENOMiHOG000232408.
KOiK02188.
OMAiLGYHGKL.
OrthoDBiPOG091H02QJ.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227.
BioCyciPMAR167555:GI3K-35-MONOMER.

Family and domain databases

HAMAPiMF_00787. CbiD. 1 hit.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCBID_PROM1
AccessioniPrimary (citable) accession number: A2BZD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.