ID   A2BYQ0_PROM5            Unreviewed;       604 AA.
AC   A2BYQ0;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   SubName: Full=Bifunctional cbiH protein and precorrin-3B C17-methyltransferase {ECO:0000313|EMBL:ABM72911.1};
DE            EC=2.1.1.131 {ECO:0000313|EMBL:ABM72911.1};
GN   Name=cobJ {ECO:0000313|EMBL:ABM72911.1};
GN   OrderedLocusNames=P9515_17041 {ECO:0000313|EMBL:ABM72911.1};
OS   Prochlorococcus marinus (strain MIT 9515).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC   Prochlorococcaceae; Prochlorococcus.
OX   NCBI_TaxID=167542 {ECO:0000313|EMBL:ABM72911.1, ECO:0000313|Proteomes:UP000001589};
RN   [1] {ECO:0000313|EMBL:ABM72911.1, ECO:0000313|Proteomes:UP000001589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9515 {ECO:0000313|EMBL:ABM72911.1,
RC   ECO:0000313|Proteomes:UP000001589};
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004953}.
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DR   EMBL; CP000552; ABM72911.1; -; Genomic_DNA.
DR   RefSeq; WP_011821003.1; NC_008817.1.
DR   AlphaFoldDB; A2BYQ0; -.
DR   STRING; 167542.P9515_17041; -.
DR   GeneID; 60200961; -.
DR   KEGG; pmc:P9515_17041; -.
DR   eggNOG; COG1010; Bacteria.
DR   eggNOG; COG2073; Bacteria.
DR   HOGENOM; CLU_009721_2_1_3; -.
DR   OrthoDB; 9772960at2; -.
DR   UniPathway; UPA00148; -.
DR   Proteomes; UP000001589; Chromosome.
DR   GO; GO:0030789; F:precorrin-3B C17-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR   Gene3D; 3.40.50.11220; -; 1.
DR   Gene3D; 3.30.420.180; CobE/GbiG C-terminal domain; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR021744; CbiG_N.
DR   InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR   InterPro; IPR002750; CobE/GbiG_C.
DR   InterPro; IPR036518; CobE/GbiG_C_sf.
DR   InterPro; IPR038029; GbiG_N_sf.
DR   NCBIfam; TIGR01466; cobJ_cbiH; 1.
DR   PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR   Pfam; PF01890; CbiG_C; 1.
DR   Pfam; PF11760; CbiG_N; 1.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF159672; CbiG N-terminal domain-like; 1.
DR   SUPFAM; SSF159664; CobE/GbiG C-terminal domain-like; 1.
DR   SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE   4: Predicted;
KW   Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:ABM72911.1};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABM72911.1}.
FT   DOMAIN          53..129
FT                   /note="Cobalamin synthesis G N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11760"
FT   DOMAIN          222..350
FT                   /note="CobE/GbiG C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01890"
FT   DOMAIN          363..566
FT                   /note="Tetrapyrrole methylase"
FT                   /evidence="ECO:0000259|Pfam:PF00590"
SQ   SEQUENCE   604 AA;  67076 MW;  F3796F899E01DEF8 CRC64;
     MKGIAIGFSD ASKEILKRLK KTEFINEIYI GSSSQIDKKI KDSIECLKPK LILKKKWKEL
     ELIIFVGSVG ASIRLINSLL SSKDKDPGII VIDKKGSKII PLIGAHQSNV QNIAFQICNL
     FGGEIIETNN SIEENYLNID SFGYQWGWKR SGDTKDWSKL VIKQANNKEI FCSQSSGNDL
     WKTSDSGKNI TQISEKDNEP NKASFNISIF SNHKNTWHPA MLWIGLGCER NTSKQLIEDS
     IQKFLATNNL SPLSIAGYAT IDIKKDEQAF LKISRENKLP IKFFRAELLS TINVPNPSNI
     VLNEIGTPSV AEAACILAAG EGAKLLGEKK IFKNIDLSKS KFGAVTIAVA RSKNQYYPLT
     GEIHVVGIGP GDISYLTNDA RKALSKCSIW IGYKMYLDLI KPLKRKDQVI IESNLTEERE
     RCEKAIKLSE EGIKVALISS GDAGVYGMAG LLLELIQTMK KELRPSFEIH PGISSMQLAA
     ALGGAPLMND FCSISLSDKL TPWESIEKRI EGALLGDFVI TIFNPQSIER NWQLKRAIKL
     VLGHRPGNTP VLVGRQVGRK NQSKRFFSLD SIPLEEIDML SIIIIGNSKT TLVDDIFLTP
     RGYL
//