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A2BY35

- PYRF_PROM5

UniProt

A2BY35 - PYRF_PROM5

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Prochlorococcus marinus (strain MIT 9515)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151SubstrateUniRule annotation
Binding sitei36 – 361SubstrateUniRule annotation
Active sitei65 – 651Proton donorUniRule annotation
Binding sitei127 – 1271SubstrateUniRule annotation
Binding sitei189 – 1891SubstrateUniRule annotation
Binding sitei198 – 1981SubstrateUniRule annotation
Binding sitei218 – 2181Substrate; via amide nitrogenUniRule annotation
Binding sitei219 – 2191SubstrateUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciPMAR167542:GI3N-1533-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:P9515_14891
OrganismiProchlorococcus marinus (strain MIT 9515)
Taxonomic identifieri167542 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001589: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Orotidine 5'-phosphate decarboxylasePRO_1000065929Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi167542.P9515_14891.

Structurei

3D structure databases

ProteinModelPortaliA2BY35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 7210Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OMAiRPITQSA.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2BY35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKINLEDKI ILAIDGLNIQ EAKLFLERCP NIKWVKVGLE LFTREGPNVI
60 70 80 90 100
KFLKDLNKKI FLDLKFHDIP NTMEAACYEV SKLGVDIISV HASSGYKALT
110 120 130 140 150
SSKNASLDGA NLASVNPPNI VGITVLTSFS SEEFRNDLDR KNSIEENVVR
160 170 180 190 200
LAKLCFDAGL DGCVCSPWEA KRLRSIYKNN FELITPGIRT KTQNKDDQNR
210 220 230
IMTPYEALKN GASRLVIGRA ISKAKDPNKV FLDICNSIY
Length:239
Mass (Da):26,738
Last modified:February 20, 2007 - v1
Checksum:i9F03ACF10AB310DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000552 Genomic DNA. Translation: ABM72696.1.
RefSeqiYP_001011803.1. NC_008817.1.

Genome annotation databases

EnsemblBacteriaiABM72696; ABM72696; P9515_14891.
GeneIDi4720053.
KEGGipmc:P9515_14891.
PATRICi23016636. VBIProMar113831_1532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000552 Genomic DNA. Translation: ABM72696.1 .
RefSeqi YP_001011803.1. NC_008817.1.

3D structure databases

ProteinModelPortali A2BY35.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167542.P9515_14891.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM72696 ; ABM72696 ; P9515_14891 .
GeneIDi 4720053.
KEGGi pmc:P9515_14891.
PATRICi 23016636. VBIProMar113831_1532.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OMAi RPITQSA.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci PMAR167542:GI3N-1533-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9515.

Entry informationi

Entry nameiPYRF_PROM5
AccessioniPrimary (citable) accession number: A2BY35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: October 1, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3