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A2BWL7

- SYL_PROM5

UniProt

A2BWL7 - SYL_PROM5

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain MIT 9515)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei631 – 6311ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR167542:GI3N-998-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:P9515_09711
OrganismiProchlorococcus marinus (strain MIT 9515)
Taxonomic identifieri167542 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001589: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Leucine--tRNA ligasePRO_0000334790Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167542.P9515_09711.

Structurei

3D structure databases

ProteinModelPortaliA2BWL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi57 – 6711"HIGH" regionAdd
BLAST
Motifi628 – 6325"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2BWL7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIYSENTDEK SNQHTNNLYK PCEIENKWQE IWDKENLYKT DDKSSKKEKF
60 70 80 90 100
YALSMFPYPS GNLHMGHVRN YVITDLIARF QRFQGKSLLH PMGWDAFGLP
110 120 130 140 150
AENAAIERGI NPNDWTKKNI AHMKSQLKLL GLSVDWDKEF ATCDENYYLW
160 170 180 190 200
TQFLFLELHK SGLVYQKESE VNWDPIDNTV LANEQVDSEG KSWRSGAKVE
210 220 230 240 250
KKLLTQWFLK ITNYTEELLQ DLEKLSEWPE RVKIMQENWI GKSKGANIIF
260 270 280 290 300
KINEFENEKI KVFTTRPDTL FGVTYIAISI NNPLINKISD NEILSKLENL
310 320 330 340 350
KIYLKKNQDK DQKKIGIPTN LKAINPINSN EIPIWIASYV LDEYGTGAVM
360 370 380 390 400
GVPAHDQRDF EFAKINFIDI KQVIIKDKDN DKSTFKLKNA FTDNGFLINS
410 420 430 440 450
NNFNGLCNND AKKQILEQGK INGWAEEEIH YRLRDWLISR QRYWGCPIPI
460 470 480 490 500
IKCNNCGSIP VNKKNLPVKL PKEIEISSNK INSLGSYKDW VKTTCPKCGN
510 520 530 540 550
LASRETDTMD TFMCSSWYFL RYPSSKCKTK PFEKDNVNKW LPVDQYVGGV
560 570 580 590 600
EHAILHLLYA RFLTKALRDN NLFDIDEPFK KLLTQGMVQA AAYKNTKTGK
610 620 630 640 650
YISPKDIKDF NNPTDPNDDS KLEVLFEKMS KSKYNGIDPE SVIKKYGADT
660 670 680 690 700
ARMFILFKAP PEKDLEWGDS DVEGQYRFLC RIWKLFLDYR NNESWDNQKN
710 720 730 740 750
YNREKENSLT KSINIAIKEI SNDIKNNQFN TAISELMKFY NSLSSSMIYV
760 770 780 790 800
NKDLRKDAFK KFCILLAPFA PHIAEEIWNL IGYQKSVHLE RWPIFNEDAL
810 820 830 840 850
KEDCYELVIQ INGKVRDKIN VGIDISEDQI KQKTLTRPNV RKWIDQKTIR
860
KIIIVKGKIM NIVV
Length:864
Mass (Da):100,650
Last modified:February 20, 2007 - v1
Checksum:i09D84245422D8C19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000552 Genomic DNA. Translation: ABM72178.1.
RefSeqiYP_001011285.1. NC_008817.1.

Genome annotation databases

EnsemblBacteriaiABM72178; ABM72178; P9515_09711.
GeneIDi4719204.
KEGGipmc:P9515_09711.
PATRICi23015544. VBIProMar113831_0997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000552 Genomic DNA. Translation: ABM72178.1 .
RefSeqi YP_001011285.1. NC_008817.1.

3D structure databases

ProteinModelPortali A2BWL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167542.P9515_09711.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM72178 ; ABM72178 ; P9515_09711 .
GeneIDi 4719204.
KEGGi pmc:P9515_09711.
PATRICi 23015544. VBIProMar113831_0997.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PMAR167542:GI3N-998-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9515.

Entry informationi

Entry nameiSYL_PROM5
AccessioniPrimary (citable) accession number: A2BWL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3