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A2BWL7

- SYL_PROM5

UniProt

A2BWL7 - SYL_PROM5

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Protein
Leucine--tRNA ligase
Gene
leuS, P9515_09711
Organism
Prochlorococcus marinus (strain MIT 9515)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei631 – 6311ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR167542:GI3N-998-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:P9515_09711
OrganismiProchlorococcus marinus (strain MIT 9515)
Taxonomic identifieri167542 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001589: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Leucine--tRNA ligaseUniRule annotation
PRO_0000334790Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167542.P9515_09711.

Structurei

3D structure databases

ProteinModelPortaliA2BWL7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi57 – 6711"HIGH" regionUniRule annotation
Add
BLAST
Motifi628 – 6325"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2BWL7-1 [UniParc]FASTAAdd to Basket

« Hide

MIYSENTDEK SNQHTNNLYK PCEIENKWQE IWDKENLYKT DDKSSKKEKF    50
YALSMFPYPS GNLHMGHVRN YVITDLIARF QRFQGKSLLH PMGWDAFGLP 100
AENAAIERGI NPNDWTKKNI AHMKSQLKLL GLSVDWDKEF ATCDENYYLW 150
TQFLFLELHK SGLVYQKESE VNWDPIDNTV LANEQVDSEG KSWRSGAKVE 200
KKLLTQWFLK ITNYTEELLQ DLEKLSEWPE RVKIMQENWI GKSKGANIIF 250
KINEFENEKI KVFTTRPDTL FGVTYIAISI NNPLINKISD NEILSKLENL 300
KIYLKKNQDK DQKKIGIPTN LKAINPINSN EIPIWIASYV LDEYGTGAVM 350
GVPAHDQRDF EFAKINFIDI KQVIIKDKDN DKSTFKLKNA FTDNGFLINS 400
NNFNGLCNND AKKQILEQGK INGWAEEEIH YRLRDWLISR QRYWGCPIPI 450
IKCNNCGSIP VNKKNLPVKL PKEIEISSNK INSLGSYKDW VKTTCPKCGN 500
LASRETDTMD TFMCSSWYFL RYPSSKCKTK PFEKDNVNKW LPVDQYVGGV 550
EHAILHLLYA RFLTKALRDN NLFDIDEPFK KLLTQGMVQA AAYKNTKTGK 600
YISPKDIKDF NNPTDPNDDS KLEVLFEKMS KSKYNGIDPE SVIKKYGADT 650
ARMFILFKAP PEKDLEWGDS DVEGQYRFLC RIWKLFLDYR NNESWDNQKN 700
YNREKENSLT KSINIAIKEI SNDIKNNQFN TAISELMKFY NSLSSSMIYV 750
NKDLRKDAFK KFCILLAPFA PHIAEEIWNL IGYQKSVHLE RWPIFNEDAL 800
KEDCYELVIQ INGKVRDKIN VGIDISEDQI KQKTLTRPNV RKWIDQKTIR 850
KIIIVKGKIM NIVV 864
Length:864
Mass (Da):100,650
Last modified:February 20, 2007 - v1
Checksum:i09D84245422D8C19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000552 Genomic DNA. Translation: ABM72178.1.
RefSeqiWP_011820280.1. NC_008817.1.
YP_001011285.1. NC_008817.1.

Genome annotation databases

EnsemblBacteriaiABM72178; ABM72178; P9515_09711.
GeneIDi4719204.
KEGGipmc:P9515_09711.
PATRICi23015544. VBIProMar113831_0997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000552 Genomic DNA. Translation: ABM72178.1 .
RefSeqi WP_011820280.1. NC_008817.1.
YP_001011285.1. NC_008817.1.

3D structure databases

ProteinModelPortali A2BWL7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 167542.P9515_09711.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM72178 ; ABM72178 ; P9515_09711 .
GeneIDi 4719204.
KEGGi pmc:P9515_09711.
PATRICi 23015544. VBIProMar113831_0997.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PMAR167542:GI3N-998-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9515.

Entry informationi

Entry nameiSYL_PROM5
AccessioniPrimary (citable) accession number: A2BWL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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