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A2BWL7 (SYL_PROM5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:P9515_09711
OrganismProchlorococcus marinus (strain MIT 9515) [Complete proteome] [HAMAP]
Taxonomic identifier167542 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length864 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 864864Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334790

Regions

Motif57 – 6711"HIGH" region HAMAP-Rule MF_00049
Motif628 – 6325"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6311ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A2BWL7 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 09D84245422D8C19

FASTA864100,650
        10         20         30         40         50         60 
MIYSENTDEK SNQHTNNLYK PCEIENKWQE IWDKENLYKT DDKSSKKEKF YALSMFPYPS 

        70         80         90        100        110        120 
GNLHMGHVRN YVITDLIARF QRFQGKSLLH PMGWDAFGLP AENAAIERGI NPNDWTKKNI 

       130        140        150        160        170        180 
AHMKSQLKLL GLSVDWDKEF ATCDENYYLW TQFLFLELHK SGLVYQKESE VNWDPIDNTV 

       190        200        210        220        230        240 
LANEQVDSEG KSWRSGAKVE KKLLTQWFLK ITNYTEELLQ DLEKLSEWPE RVKIMQENWI 

       250        260        270        280        290        300 
GKSKGANIIF KINEFENEKI KVFTTRPDTL FGVTYIAISI NNPLINKISD NEILSKLENL 

       310        320        330        340        350        360 
KIYLKKNQDK DQKKIGIPTN LKAINPINSN EIPIWIASYV LDEYGTGAVM GVPAHDQRDF 

       370        380        390        400        410        420 
EFAKINFIDI KQVIIKDKDN DKSTFKLKNA FTDNGFLINS NNFNGLCNND AKKQILEQGK 

       430        440        450        460        470        480 
INGWAEEEIH YRLRDWLISR QRYWGCPIPI IKCNNCGSIP VNKKNLPVKL PKEIEISSNK 

       490        500        510        520        530        540 
INSLGSYKDW VKTTCPKCGN LASRETDTMD TFMCSSWYFL RYPSSKCKTK PFEKDNVNKW 

       550        560        570        580        590        600 
LPVDQYVGGV EHAILHLLYA RFLTKALRDN NLFDIDEPFK KLLTQGMVQA AAYKNTKTGK 

       610        620        630        640        650        660 
YISPKDIKDF NNPTDPNDDS KLEVLFEKMS KSKYNGIDPE SVIKKYGADT ARMFILFKAP 

       670        680        690        700        710        720 
PEKDLEWGDS DVEGQYRFLC RIWKLFLDYR NNESWDNQKN YNREKENSLT KSINIAIKEI 

       730        740        750        760        770        780 
SNDIKNNQFN TAISELMKFY NSLSSSMIYV NKDLRKDAFK KFCILLAPFA PHIAEEIWNL 

       790        800        810        820        830        840 
IGYQKSVHLE RWPIFNEDAL KEDCYELVIQ INGKVRDKIN VGIDISEDQI KQKTLTRPNV 

       850        860 
RKWIDQKTIR KIIIVKGKIM NIVV 

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9515.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000552 Genomic DNA. Translation: ABM72178.1.
RefSeqYP_001011285.1. NC_008817.1.

3D structure databases

ProteinModelPortalA2BWL7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167542.P9515_09711.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM72178; ABM72178; P9515_09711.
GeneID4719204.
KEGGpmc:P9515_09711.
PATRIC23015544. VBIProMar113831_0997.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycPMAR167542:GI3N-998-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_PROM5
AccessionPrimary (citable) accession number: A2BWL7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 20, 2007
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries