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A2BW03 (AROB_PROM5) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:P9515_07551
OrganismProchlorococcus marinus (strain MIT 9515) [Complete proteome] [HAMAP]
Taxonomic identifier167542 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3633633-dehydroquinate synthase HAMAP MF_00110
PRO_1000094565

Sequences

Sequence LengthMass (Da)Tools
A2BW03 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 4BAF588DE9536D13

FASTA36340,730
        10         20         30         40         50         60 
MNKNKIIVPL SNNSYEVTIR QGIINSIGKE LTQIGINNNR KILIVSNKEI SNLFGSKLLN 

        70         80         90        100        110        120 
DLKKYNFSAE IFNIKAGESY KNLASLREIY DAAFEFGLDR NALLIALGGG IVGDVTGFAA 

       130        140        150        160        170        180 
ATWLRGIDYI QIPTTLLSMV DSSVGGKTAV NHPKGKNLIG AFYQPKAVFI DPETLKTLPI 

       190        200        210        220        230        240 
REFKAGMAEV IKYGVIKDKE LFEYLEIDKN REKILNLDNE SLIKIINKSI RTKSYIVSKD 

       250        260        270        280        290        300 
EKENGIRAIL NYGHSFGHVI ENLCGYGEYL HGEAISIGMK IAGDISTEKN LWLKEDSLRQ 

       310        320        330        340        350        360 
DKLIESYGLP TQTPKIKKHD VITILMGDKK VRDGKMRFIL PKGIGEVDIF NDIKESQFLK 


YFD

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9515.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000552 Genomic DNA. Translation: ABM71964.1.
RefSeqYP_001011071.1. NC_008817.1.

3D structure databases

ProteinModelPortalA2BW03.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2BW03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4719507.
GenomeReviewsGene locus P9515_07551 in contig CP000552_GR.
KEGGpmc:P9515_07551.
PATRIC23015100. VBIProMar113831_0777.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMALGQSDFT.
PhylomeDBA2BW03.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycPMAR167542:P9515ORF_0792-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_PROM5
AccessionPrimary (citable) accession number: A2BW03
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 20, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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