A2BVS6 (AROA_PROM5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	P9515_06781

Organism

Prochlorococcus marinus (strain MIT 9515) [Complete proteome] [HAMAP]

Taxonomic identifier

167542 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000325372

Sequences

	Sequence		Length	Mass (Da)
	A2BVS6 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: EE3DB37DAE69E5E4	FASTA	438	47,184
	10 20 30 40 50 60 MNTNDIRTVK GEKSLQGTIK VPGDKSISHR SLIIGSIAEG ETNIEGFLYS EDPLSTADCL 70 80 90 100 110 120 RKLGVHIPEI KKDQPFTIRG LGIDGFREPK EILNCGNSGT TMRLLMGLLA GQTDRNFILT 130 140 150 160 170 180 GDKSLNERPM GRVSKPLSLM GGKIYGRENG TKAPISITGN KLKGCVIGTP VASAQVKSAI 190 200 210 220 230 240 LLAGLNASGT TSVIEPASSR DHTERMLKAF GADIKIRGEL GRNIVIKSGN NLTGQNILIP 250 260 270 280 290 300 GDISSAAFWM IAASIVPESE ILVKNVGLNP TRTGILHVMD EMGCDYKIIE KSTIAGEPIG 310 320 330 340 350 360 SIKVKYVSNL KPFKVQGDIL PKLIDEIPIL TVAACFCNGV SEIKDAKELR VKETDRLKVM 370 380 390 400 410 420 ARQLKKFGAN ITEKEDGLII TGESKFHSAE VDSETDHRVS MSLAIASLLA KGSTRIARAG 430 ASNVSYPTFW DDLEKLIN

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MIT 9515.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000552 Genomic DNA. Translation: ABM71887.1.
RefSeq	YP_001010994.1. NC_008817.1.
3D structure databases
ProteinModelPortal	A2BVS6.
ModBase	Search...
Protein-protein interaction databases
STRING	A2BVS6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4719556.
GenomeReviews	Gene locus P9515_06781 in contig CP000552_GR.
KEGG	pmc:P9515_06781.
PATRIC	23014938. VBIProMar113831_0697.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	GEDPRST.
PhylomeDB	A2BVS6.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	PMAR167542:P9515ORF_0714-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_PROM5

Accession

Primary (citable) accession number: A2BVS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	February 20, 2007
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program