A2BVM1 (A2BVM1_PROM5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Hydroxyacylglutathione hydrolase HAMAP MF_01374
EC=3.1.2.6 HAMAP MF_01374

Alternative name(s):
Glyoxalase II HAMAP MF_01374

Gene names

Name:	gloB HAMAP MF_01374
Ordered Locus Names:	P9515_06231

Organism

Prochlorococcus marinus (strain MIT 9515) [Complete proteome] [HAMAP] EMBL ABM71832.1

Taxonomic identifier

167542 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP MF_01374
Catalytic activity	S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP MF_01374
Cofactor	Binds 2 zinc ions per subunit By similarity. HAMAP MF_01374
Pathway	Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374
Subunit structure	Monomer By similarity. HAMAP MF_01374
Sequence similarities	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. HAMAP MF_01374

Ontologies

Keywords
Ligand	Metal-binding HAMAP MF_01374 Zinc HAMAP MF_01374
Molecular function	Hydrolase HAMAP MF_01374 EMBL ABM71832.1
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	hydroxyacylglutathione hydrolase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	58	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	60	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	62	1	Zinc 2 By similarity HAMAP MF_01374
	Metal binding	63	1	Zinc 2 By similarity HAMAP MF_01374
	Metal binding	117	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	137	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	137	1	Zinc 2 By similarity HAMAP MF_01374
	Metal binding	175	1	Zinc 2 By similarity HAMAP MF_01374

Sequences

	Sequence		Length	Mass (Da)
	A2BVM1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 54FFD2A79D3651FF	FASTA	246	28,648
	10 20 30 40 50 60 MEFNKEQTII GIRVLSDNVI WLWRKNNSAV VIDPALSQPV IEYLKTHNLY LKAILQTHHH 70 80 90 100 110 120 HDHIGGTREL IKEWPKVKVI ASAKEKDRIP FQNLSVKDGD KLKLLDEEVH VIEVIGHTRS 130 140 150 160 170 180 HLAFYIHNKV PILFIGDTLF SAGCGRIFEG TYKQMYNSLK KIKSLPKNTT IYCAHEYTKS 190 200 210 220 230 240 NLLWALDLEP ENENIKNKLI EVEKKIALKE LTIPFLLEEE LIINLFLRAD NLKRFSYLRA NKDTWV

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000552 Genomic DNA. Translation: ABM71832.1.
RefSeq	YP_001010939.1. NC_008817.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A2BVM1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4719631.
GenomeReviews	Gene locus P9515_06231 in contig CP000552_GR.
KEGG	pmc:P9515_06231.
PATRIC	23014826. VBIProMar113831_0642.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0491.
HOGENOM	HBG753931.
OMA	FLCRTDN.
PhylomeDB	A2BVM1.
ProtClustDB	CLSK921893.
Enzyme and pathway databases
BioCyc	PMAR167542:P9515ORF_0658-MONOMER.
Family and domain databases
HAMAP	MF_01374. Glyoxalase_2. [Tree]
InterPro	IPR001279. Beta-lactamas-like. IPR017782. Hydroxyacylglutathione_Hdrlase. [Graphical view]
KO	K01069.
PANTHER	PTHR11935:SF7. PTHR11935:SF7. 1 hit.
Pfam	PF00753. Lactamase_B. 1 hit. [Graphical view]
SMART	SM00849. Lactamase_B. 1 hit. [Graphical view]
TIGRFAMs	TIGR03413. GSH_gloB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A2BVM1_PROM5

Accession

Primary (citable) accession number: A2BVM1

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)