A2BV78 (MQO_PROM5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase
EC=1.1.5.4

Alternative name(s):
MQO
Malate dehydrogenase [quinone]

Gene names

Name:	mqo
Ordered Locus Names:	P9515_04801

Organism

Prochlorococcus marinus (strain MIT 9515) [Complete proteome] [HAMAP]

Taxonomic identifier

167542 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Probable malate:quinone oxidoreductase HAMAP MF_00212		PRO_1000023813

Sequences

	Sequence		Length	Mass (Da)
	A2BV78 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: E561FE082A24B688	FASTA	497	55,883
	10 20 30 40 50 60 MTSKKFSDKK NNYDAILVGA GIMSGTLALL LTEILPELKI LIIEKLKIPG SESSGAFNNA 70 80 90 100 110 120 GTGHAANCEL NYTPLDDYGH LKIEKALSIN RSFEKSMSLW ASLYSSQKID IKKFLKFIPH 130 140 150 160 170 180 ISFVTGSENV SFLKKRFKKM TEYKEFEDME FSSSFNQISS WAPLITKSRN PLDEVAATRV 190 200 210 220 230 240 KRGTDINFEV LTREYLKYIS KNKNVEISYE TELNDLKKTS NKEWELNISM EGRKVNLKTS 250 260 270 280 290 300 YVFLGAGGKT INYLQKSNIP EAKVYGGFPV SGKWLICEEN SLTEKHNAKV YGRADIGSPP 310 320 330 340 350 360 MSVPHLDTRW IEGKKFLLYG PFAGFTTKFL KQGSYLDLFN SLKKNNLLSM LDVGIKNNDL 370 380 390 400 410 420 INYLFSQSIK SHKSRVENLR NMMPSADPSN WYLENAGQRV QIIKKTKKGG SLKFGTEIVN 430 440 450 460 470 480 AADGSLSALL GASPGASTAV SIMIEVLKKS CLFTLDKSIL EQKISHLLYE SELKNQNEND 490 FLENLKKRNN SILGFHP

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MIT 9515.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000552 Genomic DNA. Translation: ABM71689.1.
RefSeq	YP_001010796.1. NC_008817.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A2BV78.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4719232.
GenomeReviews	Gene locus P9515_04801 in contig CP000552_GR.
KEGG	pmc:P9515_04801.
PATRIC	23014534. VBIProMar113831_0498.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0579.
HOGENOM	HBG289663.
OMA	LEKEWAY.
PhylomeDB	A2BV78.
ProtClustDB	PRK05257.
Enzyme and pathway databases
BioCyc	PMAR167542:P9515ORF_0514-MONOMER.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO_PROM5

Accession

Primary (citable) accession number: A2BV78

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 20, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program