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A2BUP7

- PUR9_PROM5

UniProt

A2BUP7 - PUR9_PROM5

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Prochlorococcus marinus (strain MIT 9515)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciPMAR167542:GI3N-305-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:P9515_02991
    OrganismiProchlorococcus marinus (strain MIT 9515)
    Taxonomic identifieri167542 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001589: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Bifunctional purine biosynthesis protein PurHPRO_1000018928Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi167542.P9515_02991.

    Structurei

    3D structure databases

    ProteinModelPortaliA2BUP7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2BUP7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPLALVSVS DKTNIIPFCK DLVEKFGYNI LSSGGTAEYL TEAKVPVLKV    50
    ADFTESPEIL DGRVKTLHPK IHGGILAKRS NEEHQREILE NKLELIDLVV 100
    VNLYPFKKKV EEQCPWEEAI ENIDIGGPSM IRSAAKNHAD VAVLVDPNQY 150
    QNYIEEIKKG PLSKDFKTKL AFEAFQHTAS YDSAISNWIS KEKDLRPSNF 200
    IESYPLIKQL RYGENPHQKA LWYGLNNIGW NSAEQLQGKE LSYNNILDLE 250
    SALLTVLEFG YETKPNIKTE SIAAVILKHN NPCGASISNS ASSSFKNALK 300
    CDSVSAFGGI VAFNANVDKE TALILKDIFL ECVVAPSFDK EALEIFKTKK 350
    NLRVLKLTKE MLPKENQTCS KSIMGGILIQ DSDNQENSED SWISVTKKNP 400
    TEQEYLDLKF AWKICKHVKS NAIVVAKDQQ TLGIGAGQMN RVGASKIALE 450
    AAKEIDSGGV LASDGFFPFA DTVRLADKYG ISSIIQPGGS IRDEESIKMC 500
    DSRGISMIFT HKRHFLH 517
    Length:517
    Mass (Da):57,437
    Last modified:February 20, 2007 - v1
    Checksum:iAE9C2D43313409ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000552 Genomic DNA. Translation: ABM71508.1.
    RefSeqiYP_001010615.1. NC_008817.1.

    Genome annotation databases

    EnsemblBacteriaiABM71508; ABM71508; P9515_02991.
    GeneIDi4720172.
    KEGGipmc:P9515_02991.
    PATRICi23014124. VBIProMar113831_0303.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000552 Genomic DNA. Translation: ABM71508.1 .
    RefSeqi YP_001010615.1. NC_008817.1.

    3D structure databases

    ProteinModelPortali A2BUP7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167542.P9515_02991.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM71508 ; ABM71508 ; P9515_02991 .
    GeneIDi 4720172.
    KEGGi pmc:P9515_02991.
    PATRICi 23014124. VBIProMar113831_0303.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci PMAR167542:GI3N-305-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9515.

    Entry informationi

    Entry nameiPUR9_PROM5
    AccessioniPrimary (citable) accession number: A2BUP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3