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A2BUM1

- TRMB_PROM5

UniProt

A2BUM1 - TRMB_PROM5

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, P9515_02731
Organism
Prochlorococcus marinus (strain MIT 9515)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351S-adenosyl-L-methionine By similarity
Binding sitei60 – 601S-adenosyl-L-methionine By similarity
Binding sitei87 – 871S-adenosyl-L-methionine By similarity
Active sitei113 – 1131 By similarity
Binding sitei113 – 1131S-adenosyl-L-methionine By similarity
Binding sitei117 – 1171Substrate By similarity
Binding sitei149 – 1491Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciPMAR167542:GI3N-277-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:P9515_02731
    OrganismiProchlorococcus marinus (strain MIT 9515)
    Taxonomic identifieri167542 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001589: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000288200Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi167542.P9515_02731.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000237936.
    KOiK03439.
    OMAiVIQPEFI.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2BUM1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRQHVNPLSK NFFEIDPIPP LNEVFENPQL PLHLDIGCAS GDFLMELSLK    50
    NKNWNYIGIE IREKLVLNAN LKIKNREYKN VYFSFGNAIN ILNNTNNKTL 100
    IDAITSISFY FPDPWFKKKH HKRRVIQPEF INLLSNAMRT RSLIFIKTDV 150
    QELFEYMELT ILESLKFKKL AYEDFRVNES FNPIKTQTKR EKYVLLSQFE 200
    IYESIYIRI 209
    Length:209
    Mass (Da):24,918
    Last modified:February 20, 2007 - v1
    Checksum:i1045BB90A6C43BF8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000552 Genomic DNA. Translation: ABM71482.1.
    RefSeqiWP_011819594.1. NC_008817.1.
    YP_001010589.1. NC_008817.1.

    Genome annotation databases

    EnsemblBacteriaiABM71482; ABM71482; P9515_02731.
    GeneIDi4720144.
    KEGGipmc:P9515_02731.
    PATRICi23014068. VBIProMar113831_0276.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000552 Genomic DNA. Translation: ABM71482.1 .
    RefSeqi WP_011819594.1. NC_008817.1.
    YP_001010589.1. NC_008817.1.

    3D structure databases

    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 167542.P9515_02731.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM71482 ; ABM71482 ; P9515_02731 .
    GeneIDi 4720144.
    KEGGi pmc:P9515_02731.
    PATRICi 23014068. VBIProMar113831_0276.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000237936.
    KOi K03439.
    OMAi VIQPEFI.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci PMAR167542:GI3N-277-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9515.

    Entry informationi

    Entry nameiTRMB_PROM5
    AccessioniPrimary (citable) accession number: A2BUM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 20, 2007
    Last modified: September 3, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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