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A2BUM1

- TRMB_PROM5

UniProt

A2BUM1 - TRMB_PROM5

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Prochlorococcus marinus (strain MIT 9515)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351S-adenosyl-L-methionineUniRule annotation
Binding sitei60 – 601S-adenosyl-L-methionineUniRule annotation
Binding sitei87 – 871S-adenosyl-L-methionineUniRule annotation
Active sitei113 – 1131By similarity
Binding sitei113 – 1131S-adenosyl-L-methionineUniRule annotation
Binding sitei117 – 1171SubstrateUniRule annotation
Binding sitei149 – 1491SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPMAR167542:GI3N-277-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:P9515_02731
OrganismiProchlorococcus marinus (strain MIT 9515)
Taxonomic identifieri167542 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001589: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209tRNA (guanine-N(7)-)-methyltransferasePRO_0000288200Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167542.P9515_02731.

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000237936.
KOiK03439.
OMAiVIQPEFI.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2BUM1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRQHVNPLSK NFFEIDPIPP LNEVFENPQL PLHLDIGCAS GDFLMELSLK
60 70 80 90 100
NKNWNYIGIE IREKLVLNAN LKIKNREYKN VYFSFGNAIN ILNNTNNKTL
110 120 130 140 150
IDAITSISFY FPDPWFKKKH HKRRVIQPEF INLLSNAMRT RSLIFIKTDV
160 170 180 190 200
QELFEYMELT ILESLKFKKL AYEDFRVNES FNPIKTQTKR EKYVLLSQFE

IYESIYIRI
Length:209
Mass (Da):24,918
Last modified:February 20, 2007 - v1
Checksum:i1045BB90A6C43BF8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000552 Genomic DNA. Translation: ABM71482.1.
RefSeqiWP_011819594.1. NC_008817.1.
YP_001010589.1. NC_008817.1.

Genome annotation databases

EnsemblBacteriaiABM71482; ABM71482; P9515_02731.
GeneIDi4720144.
KEGGipmc:P9515_02731.
PATRICi23014068. VBIProMar113831_0276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000552 Genomic DNA. Translation: ABM71482.1 .
RefSeqi WP_011819594.1. NC_008817.1.
YP_001010589.1. NC_008817.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167542.P9515_02731.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM71482 ; ABM71482 ; P9515_02731 .
GeneIDi 4720144.
KEGGi pmc:P9515_02731.
PATRICi 23014068. VBIProMar113831_0276.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000237936.
KOi K03439.
OMAi VIQPEFI.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci PMAR167542:GI3N-277-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9515.

Entry informationi

Entry nameiTRMB_PROM5
AccessioniPrimary (citable) accession number: A2BUM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 20, 2007
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3