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Protein

1,4-dihydroxy-2-naphthoyl-CoA hydrolase

Gene

P9515_02021

Organism
Prochlorococcus marinus (strain MIT 9515)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.UniRule annotation

Catalytic activityi

1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA.UniRule annotation

Pathwayi: phylloquinone biosynthesis

This protein is involved in the pathway phylloquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway phylloquinone biosynthesis and in Cofactor biosynthesis.

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. 1,4-dihydroxy-2-naphthoyl-CoA hydrolase (P9515_02021)
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei19UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPMAR167542:GI3N-205-MONOMER.
UniPathwayiUPA00995.
UPA01057; UER01033.

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-dihydroxy-2-naphthoyl-CoA hydrolaseUniRule annotation (EC:3.1.2.28UniRule annotation)
Short name:
DHNA-CoA hydrolaseUniRule annotation
Alternative name(s):
DHNA-CoA thioesteraseUniRule annotation
Gene namesi
Ordered Locus Names:P9515_02021
OrganismiProchlorococcus marinus (strain MIT 9515)
Taxonomic identifieri167542 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001589 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003770231 – 1501,4-dihydroxy-2-naphthoyl-CoA hydrolaseAdd BLAST150

Interactioni

Protein-protein interaction databases

STRINGi167542.P9515_02021.

Structurei

3D structure databases

ProteinModelPortaliA2BUF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105WGP. Bacteria.
COG0824. LUCA.
HOGENOMiHOG000056134.
KOiK12073.
OMAiHEAWEES.
OrthoDBiPOG091H02B8.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_02101. DHNA_CoA_hydrolase. 1 hit.
InterProiIPR022829. DHNA_CoA_hydrolase.
IPR029069. HotDog_dom.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.

Sequencei

Sequence statusi: Complete.

A2BUF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPHSWLILK RKVRFGDCDS AGVIHFHNLL RWAHESWEES IDIYGISHQV
60 70 80 90 100
IFPSCHSHEN QNILPIVNCE ANFLLPIKLG DLLTVKIFPK KISNHLFQVN
110 120 130 140 150
TLFLKDEIKV AEGKIIHCSL DMNSKLKVKL PDQLERWIEA SNINTHLKEC
Length:150
Mass (Da):17,386
Last modified:February 20, 2007 - v1
Checksum:iE367F2F676F03B38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000552 Genomic DNA. Translation: ABM71411.1.
RefSeqiWP_011819525.1. NC_008817.1.

Genome annotation databases

EnsemblBacteriaiABM71411; ABM71411; P9515_02021.
KEGGipmc:P9515_02021.
PATRICi23013922. VBIProMar113831_0204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000552 Genomic DNA. Translation: ABM71411.1.
RefSeqiWP_011819525.1. NC_008817.1.

3D structure databases

ProteinModelPortaliA2BUF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi167542.P9515_02021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM71411; ABM71411; P9515_02021.
KEGGipmc:P9515_02021.
PATRICi23013922. VBIProMar113831_0204.

Phylogenomic databases

eggNOGiENOG4105WGP. Bacteria.
COG0824. LUCA.
HOGENOMiHOG000056134.
KOiK12073.
OMAiHEAWEES.
OrthoDBiPOG091H02B8.

Enzyme and pathway databases

UniPathwayiUPA00995.
UPA01057; UER01033.
BioCyciPMAR167542:GI3N-205-MONOMER.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_02101. DHNA_CoA_hydrolase. 1 hit.
InterProiIPR022829. DHNA_CoA_hydrolase.
IPR029069. HotDog_dom.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDNCH_PROM5
AccessioniPrimary (citable) accession number: A2BUF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.