Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fumarate hydratase class II

Gene

fumC

Organism
Prochlorococcus marinus (strain AS9601)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.UniRule annotation

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.UniRule annotation

Catalytic activityi

(S)-malate = fumarate + H2O.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes (S)-malate from fumarate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Fumarate hydratase class II (fumC)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from fumarate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei188SubstrateUniRule annotation1
Active sitei189Proton donor/acceptorUniRule annotation1
Active sitei319UniRule annotation1
Binding sitei320SubstrateUniRule annotation1
Sitei332Important for catalytic activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processTricarboxylic acid cycleUniRule annotation

Enzyme and pathway databases

BioCyciPMAR146891:G1G7X-1581-MONOMER
UniPathwayiUPA00223; UER01007

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate hydratase class IIUniRule annotation (EC:4.2.1.2UniRule annotation)
Short name:
Fumarase CUniRule annotation
Alternative name(s):
Aerobic fumaraseUniRule annotation
Iron-independent fumaraseUniRule annotation
Gene namesi
Name:fumCUniRule annotationImported
Ordered Locus Names:A9601_16681Imported
OrganismiProchlorococcus marinus (strain AS9601)Imported
Taxonomic identifieri146891 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002590 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi146891.A9601_16681

Structurei

3D structure databases

ProteinModelPortaliA2BT40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 343Lyase_1InterPro annotationAdd BLAST331
Domaini409 – 461FumaraseC_CInterPro annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni99 – 101Substrate bindingUniRule annotation3
Regioni130 – 133Substrate binding (B site)UniRule annotation4
Regioni140 – 142Substrate bindingUniRule annotation3
Regioni325 – 327Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9Q Bacteria
COG0114 LUCA
HOGENOMiHOG000061736
KOiK01679
OMAiVSFTDNC
OrthoDBiPOG091H01XG

Family and domain databases

CDDicd01362 Fumarase_classII, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00743 FumaraseC, 1 hit
InterProiView protein in InterPro
IPR005677 Fum_hydII
IPR024083 Fumarase/histidase_N
IPR018951 Fumarase_C_C
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR11444 PTHR11444, 1 hit
PfamiView protein in Pfam
PF10415 FumaraseC_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

A2BT40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKNFRIEKD SMGTIEVPME ALWGAQTQRS IINFSIGEEL IPIELIYSLT
60 70 80 90 100
LIKKAASIAN FNLGLIDKRK KDLIVEACTE ILDGLHDSQF PLKVWQTGSG
110 120 130 140 150
TQTNMNVNEV ISNIAALKTN SELGSHQPIH PNDDVNKSQS TNDTFPAAIQ
160 170 180 190 200
ISVVNEIIKN LVPTIRELTK VFDKKSEEWK DLIKIGRTHF QDAVPLTFGQ
210 220 230 240 250
EISGWSEQLK DAENAIIMSL NELYFLPLGG TAVGTGINCP KGFCEESIKS
260 270 280 290 300
ISDDTNLMFY KSKNNFSIMA SHDRLAQVMS QIKILASALF KISNDIKILS
310 320 330 340 350
SGPRSGIYEL IIPQNEPGSS IMPGKVNPTQ CEALSMVCTQ IMGLEYAVSM
360 370 380 390 400
ANSSGTLQMN EYKPLIGFNI LTSLKLLKNV IENFRKKLVD GMQPNQKKMK
410 420 430 440 450
LNLENSLMLV TAIVPKVGYE KAAEIANLAF KESLNLKEAT IKLGYLNEDE
460
FDEAMNINSM I
Length:461
Mass (Da):51,135
Last modified:February 20, 2007 - v1
Checksum:iDC4455699BCF9956
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000551 Genomic DNA Translation: ABM70951.1
RefSeqiWP_011819079.1, NC_008816.1

Genome annotation databases

EnsemblBacteriaiABM70951; ABM70951; A9601_16681
GeneIDi4718398
KEGGipmb:A9601_16681

Similar proteinsi

Entry informationi

Entry nameiA2BT40_PROMS
AccessioniPrimary (citable) accession number: A2BT40
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: February 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health