A2BRP1 (A2BRP1_PROMS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897
Ordered Locus Names:	A9601_11681

Organism

Prochlorococcus marinus (strain AS9601) [Complete proteome] [HAMAP] EMBL ABM70452.1

Taxonomic identifier

146891 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	865 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2BRP1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 2771D127828A3931	FASTA	865	96,258
	10 20 30 40 50 60 MSDILDSDNS GLSEDNDRII QTDLRNEMSR SYLEYAMSVI VGRALPDARD GLKPVHRRIL 70 80 90 100 110 120 YAMYELGLTS GRPYRKCARV VGEVLGKYHP HGDTAVYDAL VRMAQDFSMR MPLIDGHGNF 130 140 150 160 170 180 GSVDNDPPAA MRYTESRLQS LTDESLLEDI ESETVDFADN FDGSQQEPTV LPARIPQLLL 190 200 210 220 230 240 NGSSGIAVGM ATNIPPHNLG ELINGLKSII KNPSLEDREL FEIIKGPDFP TGGQILGRDG 250 260 270 280 290 300 IKETFKTGRG SITMRGVANI EQIKSTSRAE KDAVIITELP FQTNKAALIE RIADLVNEKK 310 320 330 340 350 360 LEGISDIRDE SDRDGMRIVI ELKRDAYPQV VLNNLFKLTP LQNNFSANIL ALVKGEPTTL 370 380 390 400 410 420 SLRKMLDVFL DFRVETIRRR TGFLLKKAEE RDHIVNGLLL ALGAMDEIIN LIRSAKDTVS 430 440 450 460 470 480 ARENLQADHE LSATQAEAIL QMQLRRLTAL EADKIKGEHD ELTRKINLYK QILNSKERIF 490 500 510 520 530 540 EIILEELNKI DERFSSPRKT EILDLGGGLD DIDLIANDRS VVLLTEAGYL KRMPVNEFES 550 560 570 580 590 600 TSRGSRGKAG TKTQEDDEVK LFISCNDHDT LLLFSDRGVS YALPAYRVPM SSRTAKGTPS 610 620 630 640 650 660 VQLLPIPREE KITSLVAVDS FDNDCYLLML TKAGFIKRTS LSAFSKIRSN GLIAINLEDG 670 680 690 700 710 720 DALTWVRLSR EGDSVLIGSR TGMAIHFRLD INELRPLGRT ARGVKSMNLR KGDNLVSMDV 730 740 750 760 770 780 LTSDLVDQLA KSEDITKESD ENLEVNSSEG PWVLIASAFG LGKRVPVTQF RLQKRAGMGL 790 800 810 820 830 840 RAIKFRIKDD VLVCLKVLGE GEELLFVTEK GVIVRTNADK ISQQSRAATG VKLQRLDMGD 850 860 HLSEVVLVPH EQTEEADQSN SDKEN

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000551 Genomic DNA. Translation: ABM70452.1.
RefSeq	YP_001009559.1. NC_008816.1.
3D structure databases
ProteinModelPortal	A2BRP1.
ModBase	Search...
Protein-protein interaction databases
STRING	A2BRP1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4717881.
GenomeReviews	Gene locus A9601_11681 in contig CP000551_GR.
KEGG	pmb:A9601_11681.
PATRIC	22983839. VBIProMar75723_1175.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
HOGENOM	HBG635183.
OMA	VCLKVLG.
PhylomeDB	A2BRP1.
ProtClustDB	PRK05560.
Enzyme and pathway databases
BioCyc	PMAR146891:A9601_11681-MONOMER.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A2BRP1_PROMS

Accession

Primary (citable) accession number: A2BRP1

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)