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A2BRN2

- RUVC_PROMS

UniProt

A2BRN2 - RUVC_PROMS

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Protein
Crossover junction endodeoxyribonuclease RuvC
Gene
ruvC, A9601_11591
Organism
Prochlorococcus marinus (strain AS9601)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Magnesium By similarity
Metal bindingi67 – 671Magnesium By similarity
Metal bindingi139 – 1391Magnesium By similarity
Metal bindingi142 – 1421Magnesium By similarity

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciPMAR146891:GH90-1179-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene namesi
Name:ruvC
Ordered Locus Names:A9601_11591
OrganismiProchlorococcus marinus (strain AS9601)
Taxonomic identifieri146891 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002590: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157Crossover junction endodeoxyribonuclease RuvCUniRule annotation
PRO_1000002797Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi146891.A9601_11591.

Structurei

3D structure databases

ProteinModelPortaliA2BRN2.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.

Phylogenomic databases

eggNOGiCOG0817.
HOGENOMiHOG000012182.
KOiK01159.
OMAiRQVQEMV.
OrthoDBiEOG6RG044.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC.
InterProiIPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamiPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

A2BRN2-1 [UniParc]FASTAAdd to Basket

« Hide

MRIIGIDPGL ARVGYGIIEI ENERKILLDC GVIETGKDKK EEDRLYEIFQ    50
DLNELINHWK PTVAAVEKFF FYRSSTTISV VQARGVIMMV LASKKIHVSE 100
YSPAKIKLTI AGSGKASKKD ILDAVMYNLD LDKPPKPDDS ADALAIALTK 150
LNEDGFN 157
Length:157
Mass (Da):17,470
Last modified:February 20, 2007 - v1
Checksum:iDC39558517940E3A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000551 Genomic DNA. Translation: ABM70443.1.
RefSeqiWP_011818592.1. NC_008816.1.
YP_001009550.1. NC_008816.1.

Genome annotation databases

EnsemblBacteriaiABM70443; ABM70443; A9601_11591.
GeneIDi4717872.
KEGGipmb:A9601_11591.
PATRICi22983821. VBIProMar75723_1166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000551 Genomic DNA. Translation: ABM70443.1 .
RefSeqi WP_011818592.1. NC_008816.1.
YP_001009550.1. NC_008816.1.

3D structure databases

ProteinModelPortali A2BRN2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 146891.A9601_11591.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM70443 ; ABM70443 ; A9601_11591 .
GeneIDi 4717872.
KEGGi pmb:A9601_11591.
PATRICi 22983821. VBIProMar75723_1166.

Phylogenomic databases

eggNOGi COG0817.
HOGENOMi HOG000012182.
KOi K01159.
OMAi RQVQEMV.
OrthoDBi EOG6RG044.

Enzyme and pathway databases

BioCyci PMAR146891:GH90-1179-MONOMER.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00034. RuvC.
InterProi IPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view ]
Pfami PF02075. RuvC. 1 hit.
[Graphical view ]
PRINTSi PR00696. RSOLVASERUVC.
SUPFAMi SSF53098. SSF53098. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AS9601.

Entry informationi

Entry nameiRUVC_PROMS
AccessioniPrimary (citable) accession number: A2BRN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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