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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain AS9601)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei625ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR146891:G1G7X-943-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:A9601_09721
OrganismiProchlorococcus marinus (strain AS9601)
Taxonomic identifieri146891 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002590 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093951 – 856Leucine--tRNA ligaseAdd BLAST856

Proteomic databases

PRIDEiA2BR45

Interactioni

Protein-protein interaction databases

STRINGi146891.A9601_09721

Structurei

3D structure databases

ProteinModelPortaliA2BR45
SMRiA2BR45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi53 – 63"HIGH" regionAdd BLAST11
Motifi622 – 626"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A2BR45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISPDKRYEA DTNLYNPSEI EKKWQSIWTE NNLYKTDELT ENSDKFYALS
60 70 80 90 100
MFPYPSGNLH MGHVRNYVIT DLIARFQRFK GKSVLHPMGW DAFGLPAENA
110 120 130 140 150
AIERGISPSV WTKKNISHMK SQLKLLGLSV DWDREFATCD ENYYIWTQYL
160 170 180 190 200
FLELYKSGLV YQKESEVNWD PIDNTVLANE QVDSEGKSWR SGAVVEKKLL
210 220 230 240 250
KQWFLRITNY ADELLKDLEK LDNWPERVKI MQDNWIGKSI GANINFNINT
260 270 280 290 300
NPEKNITVFT TRPDTLFGVT YLAISVNHSL IKKITDQETI QDIENLKQYL
310 320 330 340 350
KDNKNNELEK IGIKTSLIAI NPVNSEPIPI WVASYVLDEY GTGAVMGVPA
360 370 380 390 400
HDLRDFEFAK KNNIDIKQVI VKDKSEQSNE LDNAYVENGY LINSNHYNGL
410 420 430 440 450
ANTIAKLKIA EEGVNNGWAE NKIQYRLRDW LISRQRYWGC PIPIVNCKKC
460 470 480 490 500
GAVPLNQSDL PVSLPKDIEI SANKINALGN NNDWINTTCP KCGIGARKET
510 520 530 540 550
DTMDTFMCSS WYFLRYPSSK CSTKPFEKNE INKWLPVDQY VGGVEHAILH
560 570 580 590 600
LLYARFFTKA LRDNELFDID EPFKKLLTQG MVQSAAYKNN KTGKYVSPSD
610 620 630 640 650
ITDLSNPTDP IDNSKLEVLF EKMSKSKYNG IDPESVIKKY GADTARMFIL
660 670 680 690 700
FKAPPEKDLE WGDTDVEGQF RFLSRIWKLY INCAKNINSK SNSHPDKEKS
710 720 730 740 750
LIKSMNIAIK EISNDILNNQ FNTAISELMK FYNSLSNSIN DINNNLKIDA
760 770 780 790 800
LKTFCILLAP FAPHIAEEIW HLIGFKKSVH LEHWPSFNAE ALKEDSYELV
810 820 830 840 850
IQVNGKVRDK VNINNDMSED QIKELTLKRP NILKWTQDKE IRKIIIVKGK

IMNIVV
Length:856
Mass (Da):98,448
Last modified:February 20, 2007 - v1
Checksum:i757A16FBD1430C56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000551 Genomic DNA Translation: ABM70256.1
RefSeqiWP_011818411.1, NC_008816.1

Genome annotation databases

EnsemblBacteriaiABM70256; ABM70256; A9601_09721
GeneIDi4717682
KEGGipmb:A9601_09721

Similar proteinsi

Entry informationi

Entry nameiSYL_PROMS
AccessioniPrimary (citable) accession number: A2BR45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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