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A2BQX7

- UPPP_PROMS

UniProt

A2BQX7 - UPPP_PROMS

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Prochlorococcus marinus (strain AS9601)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciPMAR146891:GH90-922-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA
    Ordered Locus Names:A9601_09041
    OrganismiProchlorococcus marinus (strain AS9601)
    Taxonomic identifieri146891 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002590: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274Undecaprenyl-diphosphatasePRO_0000290745Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi146891.A9601_09041.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalUniRule annotationAdd
    BLAST
    Transmembranei47 – 6721HelicalUniRule annotationAdd
    BLAST
    Transmembranei95 – 11521HelicalUniRule annotationAdd
    BLAST
    Transmembranei120 – 14021HelicalUniRule annotationAdd
    BLAST
    Transmembranei161 – 18121HelicalUniRule annotationAdd
    BLAST
    Transmembranei197 – 21721HelicalUniRule annotationAdd
    BLAST
    Transmembranei224 – 24421HelicalUniRule annotationAdd
    BLAST
    Transmembranei254 – 27421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2BQX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRQVYNLLE YLKFFLYGLI QGFTEFIPVS STAHLKVISL FLGIDDPGAS    50
    LSATIQLGSV LAIAWYFKND IFNFRSQSSK KLIAYLLHKR LLRSILIGTI 100
    PIVLLGGSIK LFVPYFFDNV LRSNLSIALV SFLMAFFMYL ADSSRRGSIN 150
    IKNHNYSNSF LIGFFQAFAI FPGVSRSGIT ISSALISGWE RGDAAKFSFL 200
    LGIPAISLAA IVEFISSFND FFALGFFPLF VGLITTFVSS LLAIDFLLKY 250
    FSSNGLKIFI IYRVIFGIVI LLNL 274
    Length:274
    Mass (Da):30,620
    Last modified:February 20, 2007 - v1
    Checksum:i544A079060447279
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000551 Genomic DNA. Translation: ABM70188.1.
    RefSeqiWP_011818345.1. NC_008816.1.
    YP_001009295.1. NC_008816.1.

    Genome annotation databases

    EnsemblBacteriaiABM70188; ABM70188; A9601_09041.
    GeneIDi4717610.
    KEGGipmb:A9601_09041.
    PATRICi22983301. VBIProMar75723_0909.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000551 Genomic DNA. Translation: ABM70188.1 .
    RefSeqi WP_011818345.1. NC_008816.1.
    YP_001009295.1. NC_008816.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 146891.A9601_09041.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM70188 ; ABM70188 ; A9601_09041 .
    GeneIDi 4717610.
    KEGGi pmb:A9601_09041.
    PATRICi 22983301. VBIProMar75723_0909.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci PMAR146891:GH90-922-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AS9601.

    Entry informationi

    Entry nameiUPPP_PROMS
    AccessioniPrimary (citable) accession number: A2BQX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3