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A2BQX7 (UPPP_PROMS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA
Ordered Locus Names:A9601_09041
OrganismProchlorococcus marinus (strain AS9601) [Complete proteome] [HAMAP]
Taxonomic identifier146891 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290745

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane47 – 6721Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane254 – 27421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A2BQX7 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 544A079060447279

FASTA27430,620
        10         20         30         40         50         60 
MFRQVYNLLE YLKFFLYGLI QGFTEFIPVS STAHLKVISL FLGIDDPGAS LSATIQLGSV 

        70         80         90        100        110        120 
LAIAWYFKND IFNFRSQSSK KLIAYLLHKR LLRSILIGTI PIVLLGGSIK LFVPYFFDNV 

       130        140        150        160        170        180 
LRSNLSIALV SFLMAFFMYL ADSSRRGSIN IKNHNYSNSF LIGFFQAFAI FPGVSRSGIT 

       190        200        210        220        230        240 
ISSALISGWE RGDAAKFSFL LGIPAISLAA IVEFISSFND FFALGFFPLF VGLITTFVSS 

       250        260        270 
LLAIDFLLKY FSSNGLKIFI IYRVIFGIVI LLNL 

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AS9601.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000551 Genomic DNA. Translation: ABM70188.1.
RefSeqYP_001009295.1. NC_008816.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING146891.A9601_09041.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM70188; ABM70188; A9601_09041.
GeneID4717610.
KEGGpmb:A9601_09041.
PATRIC22983301. VBIProMar75723_0909.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBCLSK922039.

Enzyme and pathway databases

BioCycPMAR146891:GH90-922-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_PROMS
AccessionPrimary (citable) accession number: A2BQX7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 20, 2007
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families