A2BQS4 (A2BQS4_PROMS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523
EC=2.3.1.- HAMAP MF_00523

Gene names

Name:	lpxD HAMAP MF_00523
Ordered Locus Names:	A9601_08511

Organism

Prochlorococcus marinus (strain AS9601) [Complete proteome] [HAMAP] EMBL ABM70135.1

Taxonomic identifier

146891 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523 UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl-carrier-protein]. SAAS SAAS020573
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523 Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6. SAAS SAAS020573
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily. HAMAP MF_00523

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00523 SAAS SAAS020573 Lipid synthesis
Domain	Repeat HAMAP MF_00523 SAAS SAAS020573
Molecular function	Acyltransferase HAMAP MF_00523 SAAS SAAS020573 EMBL ABM70135.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2BQS4 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: E17B121C11E027E9	FASTA	344	36,955
	10 20 30 40 50 60 MLLSDLVDLI KKGNSNFISA NIFEDLNIDD AASLDAAVKH QISFLEENNI LKEKLDQTKA 70 80 90 100 110 120 SAIITTNNDE IVSALKKLNI SSIIVKNPRI AFAEVLDYLY KTINFKPGIH ASAVIDKTAI 130 140 150 160 170 180 IGADCHIGPN VYIGENTVIG DNNHILPGSS ILGNVQIGNN NIIHPNCVIY ENTTLKNNCV 190 200 210 220 230 240 INSNSVIGSE GFGYIPENGK WVKMPQKGGV KIMSFVEIGT NCCIDRPAVG FTFIDEGTKL 250 260 270 280 290 300 DNLIQIGHGV KIGKNCAFAA QVGIAGGANI GDGVILAGQV GVNNRVKVGN NVIASSKCGI 310 320 330 340 HCDIEDGKVI SGFPAMENKS WLRSSSIFKK LPELAKKLRQ LDKQ

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000551 Genomic DNA. Translation: ABM70135.1.
RefSeq	YP_001009242.1. NC_008816.1.
3D structure databases
ProteinModelPortal	A2BQS4.
ModBase	Search...
Protein-protein interaction databases
STRING	A2BQS4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4717556.
GenomeReviews	Gene locus A9601_08511 in contig CP000551_GR.
KEGG	pmb:A9601_08511.
PATRIC	22983195. VBIProMar75723_0856.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1044.
HOGENOM	HBG469615.
OMA	CFVGKNT.
PhylomeDB	A2BQS4.
ProtClustDB	PRK00892.
Enzyme and pathway databases
BioCyc	PMAR146891:A9601_08511-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 4 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A2BQS4_PROMS

Accession

Primary (citable) accession number: A2BQS4

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)