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A2BQG2 (AROB_PROMS) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:A9601_07371
OrganismProchlorococcus marinus (strain AS9601) [Complete proteome] [HAMAP]
Taxonomic identifier146891 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3633633-dehydroquinate synthase HAMAP MF_00110
PRO_1000094567

Sequences

Sequence LengthMass (Da)Tools
A2BQG2 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: B28C4E846D6E9F49

FASTA36340,725
        10         20         30         40         50         60 
MNKRKILVPL GDKSYEVTLE AGILNNISEE LLKIGITKKR KILVISNEEI SNLYGEKFLN 

        70         80         90        100        110        120 
NLKDNKFQAK MFLIKAGESY KNLKTLSEIY DVAFEFGLDR NSIIIALGGG IVGDVSGFAA 

       130        140        150        160        170        180 
ATWLRGIEYI QIPTTLLSMV DSSVGGKTGV NHPKGKNLIG AFNQPKAVFI DPETLKSLPK 

       190        200        210        220        230        240 
REFSAGMAEV IKYGVIRDKE LFEYLEIEKN KNELINLKNE YLIKIINSSI KTKSNVVSQD 

       250        260        270        280        290        300 
EHENGVRAIL NYGHSFGHVI ENLCGYGKFL HGEAISIGMN IAGKIAIEKG LWSKEELERQ 

       310        320        330        340        350        360 
RILLESYDLP TEIPKINKED VLTILMGDKK VRDGKMRFIL PKEIGAVDIY DDVEDSLFLK 


FFS

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AS9601.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000551 Genomic DNA. Translation: ABM70023.1.
RefSeqYP_001009130.1. NC_008816.1.

3D structure databases

ProteinModelPortalA2BQG2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2BQG2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4717442.
GenomeReviewsGene locus A9601_07371 in contig CP000551_GR.
KEGGpmb:A9601_07371.
PATRIC22982964. VBIProMar75723_0741.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAGTFTQPD.
PhylomeDBA2BQG2.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycPMAR146891:A9601_07371-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_PROMS
AccessionPrimary (citable) accession number: A2BQG2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 20, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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