A2BQ50 (A2BQ50_PROMS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dihydroorotase EMBL ABM69911.1
EC=3.5.2.3 EMBL ABM69911.1

Gene names

Ordered Locus Names:

A9601_06251

Organism

Prochlorococcus marinus (strain AS9601) [Complete proteome] [HAMAP] EMBL ABM69911.1

Taxonomic identifier

146891 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. SAAS SAAS004721
Cofactor	Binds 2 zinc ions per subunit By similarity. SAAS SAAS004721
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. SAAS SAAS004721
Subunit structure	Homodimer By similarity. SAAS SAAS004721

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis SAAS SAAS004721
Ligand	Metal-binding SAAS SAAS004721 Zinc SAAS SAAS004721
Molecular function	Hydrolase SAAS SAAS004721 EMBL ABM69911.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	dihydroorotase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2BQ50 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 88D0AA929B3AA0FF	FASTA	349	39,815
	10 20 30 40 50 60 MKTLNIIKPD DWHLHLREGL VLKNIIQFTS EYFGRAIVMP NTKSPITSIN RAISYRKSIV 70 80 90 100 110 120 EALPESSKFE PLMTIYLTDE TDKRELINGF KNNVFFAAKL YPANATTNSS HGVRKIENLY 130 140 150 160 170 180 KIFELMQDSG MPLLIHGEVT DSEVDVFDRE EVFIDKELSQ ITKRFPKLKI VLEHITTSYA 190 200 210 220 230 240 VDFVQENNIG ATITPHHLHI NRNAMFFGGL NSDFYCLPVA KRENNRLALR KAATSGKKCF 250 260 270 280 290 300 FLGTDSAPHL RKWKAFCGCA GIFNSPVALE SYLTVFEEED ALDNFEKFAS LNGPNFYNVP 310 320 330 340 PNKEKLKLVS RPYKIKEYID VVEEKNIVGQ IKPFHAGETL QWQVEGIAN

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000551 Genomic DNA. Translation: ABM69911.1.
RefSeq	YP_001009018.1. NC_008816.1.
3D structure databases
ProteinModelPortal	A2BQ50.
ModBase	Search...
Protein-protein interaction databases
STRING	A2BQ50.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4717325.
GenomeReviews	Gene locus A9601_06251 in contig CP000551_GR.
KEGG	pmb:A9601_06251.
PATRIC	22982728. VBIProMar75723_0625.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0418.
HOGENOM	HBG628648.
OMA	CLPVAKR.
PhylomeDB	A2BQ50.
ProtClustDB	PRK05451.
Enzyme and pathway databases
BioCyc	PMAR146891:A9601_06251-MONOMER.
Family and domain databases
InterPro	IPR006680. Amidohydro_1. IPR004721. DHOdimr. IPR002195. Dihydroorotase_CS. [Graphical view]
KO	K01465.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
PIRSF	PIRSF001237. DHOdimr. 1 hit.
TIGRFAMs	TIGR00856. PyrC_dimer. 1 hit.
PROSITE	PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A2BQ50_PROMS

Accession

Primary (citable) accession number: A2BQ50

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)