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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Prochlorococcus marinus (strain AS9601)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei251ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR146891:G1G7X-517-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:A9601_05281
OrganismiProchlorococcus marinus (strain AS9601)
Taxonomic identifieri146891 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002590 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000019351 – 476Glutamate--tRNA ligaseAdd BLAST476

Proteomic databases

PRIDEiA2BPV5

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi146891.A9601_05281

Structurei

3D structure databases

ProteinModelPortaliA2BPV5
SMRiA2BPV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi248 – 252"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
1.10.1160.10, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020061 Glu_tRNA_lig_a-bdl
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A2BPV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKRLRLAPS PTGLFHIGTA RTALFNWLYA QKIGGKFLIR IEDTDFLRSK
60 70 80 90 100
SEYTKNILQG LKWLGLKWDE EPIKQSDRIS IHKSHIKKLL ECGAAYRCFT
110 120 130 140 150
SEDEISELRE EQKKKGLPPK HDNRHRSLSK EEIETFISQG RTSVIRFKID
160 170 180 190 200
EKIVIKWIDQ IRGEIKWQGK DLGGDLVLSR RAKGYEIGDP LYNLAVVVDD
210 220 230 240 250
NFMNITHVVR GEDHISNTAK QILIYNALNF NLPTFSHTPL ILNSEGKKLS
260 270 280 290 300
KRDCVTSIDE FREMGYLPEA LSNYMAFLGW SPKTADREIL SLEEISEIFD
310 320 330 340 350
LSEINKAGAK FSWEKLNWIN SQYIKNMESI KLVEIMRTYW DENGWEPPSQ
360 370 380 390 400
EWANKLAILI RDSMTLLKDS IDQSKPFFLI PTIQKEGQDF LENRESKLSL
410 420 430 440 450
KLILNYLIEK NTIKLNKEKA KEIINEISKK HNIKKGILMK SLRVAFFGSL
460 470
IGPDLIQSWE LFAESKTDRT RIERCL
Length:476
Mass (Da):55,285
Last modified:February 20, 2007 - v1
Checksum:i9D34A58CE8DBBCAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000551 Genomic DNA Translation: ABM69816.1
RefSeqiWP_011817983.1, NC_008816.1

Genome annotation databases

EnsemblBacteriaiABM69816; ABM69816; A9601_05281
GeneIDi4717226
KEGGipmb:A9601_05281

Similar proteinsi

Entry informationi

Entry nameiSYE_PROMS
AccessioniPrimary (citable) accession number: A2BPV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health