A2BMK0 (A2BMK0_HYPBU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

Hbut_1386

Organism

Hyperthermus butylicus (strain DSM 5456 / JCM 9403)

Taxonomic identifier

415426 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Pyrodictiaceae › Hyperthermus

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515 PIRSR PIRSR001415-3
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515 EMBL ABM81211.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	203	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	256	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	124	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	126	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	134	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	241	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	213	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	225	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	283	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	322	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	A2BMK0 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 07D97D265DB2CEC1	FASTA	338	37,617
	10 20 30 40 50 60 MPGFPELRPR RLRLTKAIRD LVAETLVSPS QLMMPIFVKE GIKEPEPIPS MPGQYRYPPE 70 80 90 100 110 120 RVVDVIREAL DLGIKSFLLF GVVPDEKKDL RGTYAYDPRG PVPTAIRLIR RELGWEPAIF 130 140 150 160 170 180 TDVCICGYTT HGHCGIPVER HGRQLIDNDS TLEVIARIAV THAEAGADFV APSGMMDGMV 190 200 210 220 230 240 SAIREALDDA GYTEVGIMSY AVKYASGFYG PFREAAGSAP RFGDRRSYQM DPRNAMEAIK 250 260 270 280 290 300 EAMLDIEEGA DILMVKPALA YLDVIRLVKE AFPQYPLAAY NVSAEYSMVK AAAEKGWIDE 310 320 330 KLVTMEIITA IRRAGADIVI TYHALDVARW LREGYSPF

References

[1]

"The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C." Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M., She Q., Garrett R.A., Klenk H.-P. Archaea 2:127-135(2007) [PubMed: 17350933] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 5456 / JCM 9403.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000493 Genomic DNA. Translation: ABM81211.1.
RefSeq	YP_001013556.1. NC_008818.1.
3D structure databases
ProteinModelPortal	A2BMK0.
SMR	A2BMK0. Positions 7-332.
ModBase	Search...
Protein-protein interaction databases
STRING	A2BMK0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4781943.
GenomeReviews	Gene locus Hbut_1386 in contig CP000493_GR.
KEGG	hbu:Hbut_1386.
Phylogenomic databases
eggNOG	arNOG05029.
HOGENOM	HBG285270.
OMA	ADLCFCE.
PhylomeDB	A2BMK0.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A2BMK0_HYPBU

Accession

Primary (citable) accession number: A2BMK0

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)