A2BLY5 (DCD_HYPBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	Hbut_1159

Organism

Hyperthermus butylicus (strain DSM 5456 / JCM 9403) [Reference proteome] [HAMAP]

Taxonomic identifier

415426 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Pyrodictiaceae › Hyperthermus › Hyperthermus butylicus

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP-Rule MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP-Rule MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dUMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine ribonucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	dCTP deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Probable deoxycytidine triphosphate deaminase HAMAP-Rule MF_00146		PRO_1000009740

Sequences

	Sequence		Length	Mass (Da)
	A2BLY5 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 884D9B5995938104	FASTA	176	20,022
	10 20 30 40 50 60 MILSDRDIAW YIEKGLLRID PLLDDTIREN GVDLRLDSEF CRFNPDAPEL DTRKPFNREI 70 80 90 100 110 120 YYNCVKVDPE QGFTVKPYEH VLATTMETVC LPDDLVGLVN VRSTFARYGI FVPPTVIDAG 130 140 150 160 170 FCGQITIEII GSAYPVRLYP GQRFLHVVFV RTTSPVANPY HGKYQGQRGV TPPRPD

References

[1]

"The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C." Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M., She Q., Garrett R.A., Klenk H.-P. Archaea 2:127-135(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 5456 / JCM 9403.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000493 Genomic DNA. Translation: ABM80996.1.
RefSeq	YP_001013341.1. NC_008818.1.
3D structure databases
ProteinModelPortal	A2BLY5.
ModBase	Search...
Protein-protein interaction databases
STRING	415426.Hbut_1159.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABM80996; ABM80996; Hbut_1159.
GeneID	4782584.
KEGG	hbu:Hbut_1159.
Phylogenomic databases
eggNOG	COG0717.
HOGENOM	HOG000228601.
KO	K01494.
OMA	GSFAWVD.
ProtClustDB	PRK00416.
Enzyme and pathway databases
BioCyc	HBUT415426:GC56-1159-MONOMER.
UniPathway	UPA00610; UER00665.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase.
InterPro	IPR011962. dCTP_deam. IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. dCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_HYPBU

Accession

Primary (citable) accession number: A2BLY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 20, 2007
Last modified:	May 29, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program