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A2BLD4

- SYW_HYPBU

UniProt

A2BLD4 - SYW_HYPBU

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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHBUT415426:GC56-947-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:Hbut_0947
OrganismiHyperthermus butylicus (strain DSM 5456 / JCM 9403)
Taxonomic identifieri415426 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaeHyperthermus
ProteomesiUP000002593: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Tryptophan--tRNA ligasePRO_1000018995Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi415426.Hbut_0947.

Structurei

3D structure databases

ProteinModelPortaliA2BLD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi79 – 879"HIGH" region
Motifi257 – 2615"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000224743.
KOiK01867.
OMAiKTFIFNN.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

A2BLD4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGYRLDPWA SAIRLEYEKL FRYFGIKPFQ PLLPEVEKAF GKPHRLMRRG
60 70 80 90 100
IIFGHRDYEK ILEAYRSGER IALVTGFMPS GKFHFGHKMV ADQIIYYQKL
110 120 130 140 150
GFEIFVVIAD AEAYAVRRLD RRKIIEIGLY EYVANLIALG LEKNKHTHIY
160 170 180 190 200
FQTNYETPYY RLIQMFSRRV TLEEMSAIYG DLEPSKIMAA LTQAADILHP
210 220 230 240 250
QLDYFGGFKY VVVPVGADQD PHIRLTRDIA ARFENELGLR RPASTYHRFQ
260 270 280 290 300
TGLDGNKMSS SRPEYTIFLT DPVDIAVRKL KRALTGGRAT VEEQRRLGGE
310 320 330 340 350
PEKCTVYEFY LYHLIEDDTQ LRKIYEDCRG SRLLCGPDKE YAAELLAKFL
360 370
EEHQRRLERA RDRVLEYVEP PKF
Length:373
Mass (Da):43,646
Last modified:February 20, 2007 - v1
Checksum:iF351ABD38649A86C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000493 Genomic DNA. Translation: ABM80795.1.
RefSeqiWP_011822113.1. NC_008818.1.
YP_001013140.1. NC_008818.1.

Genome annotation databases

EnsemblBacteriaiABM80795; ABM80795; Hbut_0947.
GeneIDi4782824.
KEGGihbu:Hbut_0947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000493 Genomic DNA. Translation: ABM80795.1 .
RefSeqi WP_011822113.1. NC_008818.1.
YP_001013140.1. NC_008818.1.

3D structure databases

ProteinModelPortali A2BLD4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 415426.Hbut_0947.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM80795 ; ABM80795 ; Hbut_0947 .
GeneIDi 4782824.
KEGGi hbu:Hbut_0947.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000224743.
KOi K01867.
OMAi KTFIFNN.

Enzyme and pathway databases

BioCyci HBUT415426:GC56-947-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C."
    Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M., She Q., Garrett R.A., Klenk H.-P.
    Archaea 2:127-135(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5456 / JCM 9403.

Entry informationi

Entry nameiSYW_HYPBU
AccessioniPrimary (citable) accession number: A2BLD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3