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A2BLD4

- SYW_HYPBU

UniProt

A2BLD4 - SYW_HYPBU

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Protein
Tryptophan--tRNA ligase
Gene
trpS, Hbut_0947
Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHBUT415426:GC56-947-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:Hbut_0947
OrganismiHyperthermus butylicus (strain DSM 5456 / JCM 9403)
Taxonomic identifieri415426 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaeHyperthermus
ProteomesiUP000002593: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Tryptophan--tRNA ligaseUniRule annotation
PRO_1000018995Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi415426.Hbut_0947.

Structurei

3D structure databases

ProteinModelPortaliA2BLD4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi79 – 879"HIGH" regionUniRule annotation
Motifi257 – 2615"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000224743.
KOiK01867.
OMAiKTFIFNN.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

A2BLD4-1 [UniParc]FASTAAdd to Basket

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MEGYRLDPWA SAIRLEYEKL FRYFGIKPFQ PLLPEVEKAF GKPHRLMRRG    50
IIFGHRDYEK ILEAYRSGER IALVTGFMPS GKFHFGHKMV ADQIIYYQKL 100
GFEIFVVIAD AEAYAVRRLD RRKIIEIGLY EYVANLIALG LEKNKHTHIY 150
FQTNYETPYY RLIQMFSRRV TLEEMSAIYG DLEPSKIMAA LTQAADILHP 200
QLDYFGGFKY VVVPVGADQD PHIRLTRDIA ARFENELGLR RPASTYHRFQ 250
TGLDGNKMSS SRPEYTIFLT DPVDIAVRKL KRALTGGRAT VEEQRRLGGE 300
PEKCTVYEFY LYHLIEDDTQ LRKIYEDCRG SRLLCGPDKE YAAELLAKFL 350
EEHQRRLERA RDRVLEYVEP PKF 373
Length:373
Mass (Da):43,646
Last modified:February 20, 2007 - v1
Checksum:iF351ABD38649A86C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000493 Genomic DNA. Translation: ABM80795.1.
RefSeqiWP_011822113.1. NC_008818.1.
YP_001013140.1. NC_008818.1.

Genome annotation databases

EnsemblBacteriaiABM80795; ABM80795; Hbut_0947.
GeneIDi4782824.
KEGGihbu:Hbut_0947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000493 Genomic DNA. Translation: ABM80795.1 .
RefSeqi WP_011822113.1. NC_008818.1.
YP_001013140.1. NC_008818.1.

3D structure databases

ProteinModelPortali A2BLD4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 415426.Hbut_0947.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM80795 ; ABM80795 ; Hbut_0947 .
GeneIDi 4782824.
KEGGi hbu:Hbut_0947.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000224743.
KOi K01867.
OMAi KTFIFNN.

Enzyme and pathway databases

BioCyci HBUT415426:GC56-947-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C."
    Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M., She Q., Garrett R.A., Klenk H.-P.
    Archaea 2:127-135(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5456 / JCM 9403.

Entry informationi

Entry nameiSYW_HYPBU
AccessioniPrimary (citable) accession number: A2BLD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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