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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:Hbut_0947
OrganismiHyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)
Taxonomic identifieri415426 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaeHyperthermus
Proteomesi
  • UP000002593 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000189951 – 373Tryptophan--tRNA ligaseAdd BLAST373

Interactioni

Protein-protein interaction databases

STRINGi415426.Hbut_0947

Structurei

3D structure databases

ProteinModelPortaliA2BLD4
SMRiA2BLD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi79 – 87"HIGH" region9
Motifi257 – 261"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
HOGENOMiHOG000224743
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z044X

Family and domain databases

Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

A2BLD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGYRLDPWA SAIRLEYEKL FRYFGIKPFQ PLLPEVEKAF GKPHRLMRRG
60 70 80 90 100
IIFGHRDYEK ILEAYRSGER IALVTGFMPS GKFHFGHKMV ADQIIYYQKL
110 120 130 140 150
GFEIFVVIAD AEAYAVRRLD RRKIIEIGLY EYVANLIALG LEKNKHTHIY
160 170 180 190 200
FQTNYETPYY RLIQMFSRRV TLEEMSAIYG DLEPSKIMAA LTQAADILHP
210 220 230 240 250
QLDYFGGFKY VVVPVGADQD PHIRLTRDIA ARFENELGLR RPASTYHRFQ
260 270 280 290 300
TGLDGNKMSS SRPEYTIFLT DPVDIAVRKL KRALTGGRAT VEEQRRLGGE
310 320 330 340 350
PEKCTVYEFY LYHLIEDDTQ LRKIYEDCRG SRLLCGPDKE YAAELLAKFL
360 370
EEHQRRLERA RDRVLEYVEP PKF
Length:373
Mass (Da):43,646
Last modified:February 20, 2007 - v1
Checksum:iF351ABD38649A86C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000493 Genomic DNA Translation: ABM80795.1
RefSeqiWP_011822113.1, NC_008818.1

Genome annotation databases

EnsemblBacteriaiABM80795; ABM80795; Hbut_0947
GeneIDi4782824
KEGGihbu:Hbut_0947

Similar proteinsi

Entry informationi

Entry nameiSYW_HYPBU
AccessioniPrimary (citable) accession number: A2BLD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health