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A2BLD4

- SYW_HYPBU

UniProt

A2BLD4 - SYW_HYPBU

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHBUT415426:GC56-947-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:Hbut_0947
    OrganismiHyperthermus butylicus (strain DSM 5456 / JCM 9403)
    Taxonomic identifieri415426 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaeHyperthermus
    ProteomesiUP000002593: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373Tryptophan--tRNA ligasePRO_1000018995Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi415426.Hbut_0947.

    Structurei

    3D structure databases

    ProteinModelPortaliA2BLD4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi79 – 879"HIGH" region
    Motifi257 – 2615"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000224743.
    KOiK01867.
    OMAiKTFIFNN.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_A. Trp_tRNA_synth_A.
    InterProiIPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2BLD4-1 [UniParc]FASTAAdd to Basket

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    MEGYRLDPWA SAIRLEYEKL FRYFGIKPFQ PLLPEVEKAF GKPHRLMRRG    50
    IIFGHRDYEK ILEAYRSGER IALVTGFMPS GKFHFGHKMV ADQIIYYQKL 100
    GFEIFVVIAD AEAYAVRRLD RRKIIEIGLY EYVANLIALG LEKNKHTHIY 150
    FQTNYETPYY RLIQMFSRRV TLEEMSAIYG DLEPSKIMAA LTQAADILHP 200
    QLDYFGGFKY VVVPVGADQD PHIRLTRDIA ARFENELGLR RPASTYHRFQ 250
    TGLDGNKMSS SRPEYTIFLT DPVDIAVRKL KRALTGGRAT VEEQRRLGGE 300
    PEKCTVYEFY LYHLIEDDTQ LRKIYEDCRG SRLLCGPDKE YAAELLAKFL 350
    EEHQRRLERA RDRVLEYVEP PKF 373
    Length:373
    Mass (Da):43,646
    Last modified:February 20, 2007 - v1
    Checksum:iF351ABD38649A86C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000493 Genomic DNA. Translation: ABM80795.1.
    RefSeqiWP_011822113.1. NC_008818.1.
    YP_001013140.1. NC_008818.1.

    Genome annotation databases

    EnsemblBacteriaiABM80795; ABM80795; Hbut_0947.
    GeneIDi4782824.
    KEGGihbu:Hbut_0947.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000493 Genomic DNA. Translation: ABM80795.1 .
    RefSeqi WP_011822113.1. NC_008818.1.
    YP_001013140.1. NC_008818.1.

    3D structure databases

    ProteinModelPortali A2BLD4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 415426.Hbut_0947.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM80795 ; ABM80795 ; Hbut_0947 .
    GeneIDi 4782824.
    KEGGi hbu:Hbut_0947.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000224743.
    KOi K01867.
    OMAi KTFIFNN.

    Enzyme and pathway databases

    BioCyci HBUT415426:GC56-947-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_A. Trp_tRNA_synth_A.
    InterProi IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C."
      Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M., She Q., Garrett R.A., Klenk H.-P.
      Archaea 2:127-135(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 5456 / JCM 9403.

    Entry informationi

    Entry nameiSYW_HYPBU
    AccessioniPrimary (citable) accession number: A2BLD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3