A2BKC0 (ECX1_HYPBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable exosome complex exonuclease 1
EC=3.1.13.-

Gene names

Ordered Locus Names:

Hbut_0571

Organism

Hyperthermus butylicus (strain DSM 5456 / JCM 9403)

Taxonomic identifier

415426 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Pyrodictiaceae › Hyperthermus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probably involved in the 3'->5' degradation of a variety of RNA species Potential. HAMAP MF_00591
Subunit structure	Component of the archaeal exosome multienzyme ribonuclease complex Potential.
Subcellular location	Cytoplasm Potential HAMAP MF_00591.
Sequence similarities	Belongs to the RNase PH family.

Ontologies

Keywords
Cellular component	Cytoplasm Exosome
Molecular function	Exonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell exosome (RNase complex) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro exoribonuclease activity, producing 5'-phosphomonoesters Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Probable exosome complex exonuclease 1 HAMAP MF_00591		PRO_1000146956

Sequences

	Sequence		Length	Mass (Da)
	A2BKC0 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 4AC9EF94041D7568	FASTA	255	27,786
	10 20 30 40 50 60 MAGGAGEKPT LIRWEERDGQ KVAIRHDGRL PEQLRPIRME VGVLSNADGS ALVEYGGTRV 70 80 90 100 110 120 IAAVYGPREA HPRHVALPDR AIIRCRYHMA PFSTAERKTP APTRREVELS KVIREALEAV 130 140 150 160 170 180 VISELYPRTA IDVYMEVLQS DGGTRTAAIT AASLALADAG IAMRDLVAGV AVGKVDGVLV 190 200 210 220 230 240 LDIDEIEDNY AEADMPVAMA PSLDKVLLLQ LNGVLTHDEF VKALELARKG IQVIYNLQKE 250 ALRKKYVEVS VEEGA

References

[1]

"The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C." Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M., She Q., Garrett R.A., Klenk H.-P. Archaea 2:127-135(2007) [PubMed: 17350933] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 5456 / JCM 9403.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000493 Genomic DNA. Translation: ABM80431.1.
RefSeq	YP_001012776.1. NC_008818.1.
3D structure databases
ProteinModelPortal	A2BKC0.
SMR	A2BKC0. Positions 25-254.
ModBase	Search...
Protein-protein interaction databases
STRING	A2BKC0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4782637.
GenomeReviews	Gene locus Hbut_0571 in contig CP000493_GR.
KEGG	hbu:Hbut_0571.
Phylogenomic databases
eggNOG	arNOG04562.
HOGENOM	HBG737187.
OMA	HMAPFST.
PhylomeDB	A2BKC0.
Enzyme and pathway databases
BioCyc	HBUT415426:HBUT_0571-MONOMER.
Family and domain databases
HAMAP	MF_00591. Exosome_Exonucl_1. [Tree]
InterPro	IPR011807. ExoRNase_exosome_complex. IPR001247. ExoRNase_PH_dom1. IPR015847. ExoRNase_PH_dom2. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
KO	K11600.
Pfam	PF01138. RNase_PH. 1 hit. PF03725. RNase_PH_C. 1 hit. [Graphical view]
SUPFAM	SSF55666. 3_ExoRNase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR02065. ECX1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ECX1_HYPBU

Accession

Primary (citable) accession number: A2BKC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	February 20, 2007
Last modified:	November 16, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program