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A2BKA9 (A2BKA9_HYPBU) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6,7-dimethyl-8-ribityllumazine synthase HAMAP MF_00178
Short name=DMRL synthase HAMAP MF_00178
Short name=Lumazine synthase HAMAP MF_00178
EC=2.5.1.9 HAMAP MF_00178
Alternative name(s):
Riboflavin synthase beta chain HAMAP MF_00178
Gene names
Name:ribH HAMAP MF_00178
Ordered Locus Names:Hbut_0560
OrganismHyperthermus butylicus (strain DSM 5456 / JCM 9403)
Taxonomic identifier415426 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Pyrodictiaceae › Hyperthermus

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate yielding 6,7-dimethyl-8-lumazine By similarity. HAMAP MF_00178

Catalytic activity

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. HAMAP MF_00178 RuleBase RU003795

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2. HAMAP MF_00178 RuleBase RU003795

Sequence similarities

Belongs to the DMRL synthase family. HAMAP MF_00178 RuleBase RU003795

Sequences

Sequence LengthMass (Da)Tools
A2BKA9 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: DF950D292A5E077C

FASTA15417,040
        10         20         30         40         50         60 
MSAADVRLAF VVAEFNYDVT YLMLQRALSY ARFRGATVTY IVYSPGAYDM PILVEELLIK 

        70         80         90        100        110        120 
DDVDAVVALG AIITGATKHD EVIAHQVARK LMDLAEKHGK PVTLGISGPG MNRVQALERV 

       130        140        150 
DDYARRAVEA AVKLAKRLKM LREARFEGET VTIQ

« Hide

References

[1]"The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C."
Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M., She Q., Garrett R.A., Klenk H.-P.
Archaea 2:127-135(2007) [PubMed: 17350933] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 5456 / JCM 9403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000493 Genomic DNA. Translation: ABM80420.1.
RefSeqYP_001012765.1. NC_008818.1.

3D structure databases

ProteinModelPortalA2BKA9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2BKA9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4781803.
GenomeReviewsGene locus Hbut_0560 in contig CP000493_GR.
KEGGhbu:Hbut_0560.

Phylogenomic databases

eggNOGarNOG09975.
HOGENOMHBG311126.
OMAIQGATKH.

Family and domain databases

HAMAPMF_00178. Lumazine_synth.
[Tree]
InterProIPR002180. DMRL_synthase.
[Graphical view]
Gene3DG3DSA:3.40.50.960. DMRL_synthase. 1 hit.
KOK00794.
PANTHERPTHR21058. DMRL_synthase. 1 hit.
PfamPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMSSF52121. DMRL_synthase. 1 hit.
TIGRFAMsTIGR00114. Lumazine-synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA2BKA9_HYPBU
AccessionPrimary (citable) accession number: A2BKA9
Entry history
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 16, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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