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A2BK91

- SYE_HYPBU

UniProt

A2BK91 - SYE_HYPBU

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHBUT415426:GC56-542-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:Hbut_0542
    OrganismiHyperthermus butylicus (strain DSM 5456 / JCM 9403)
    Taxonomic identifieri415426 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaeHyperthermus
    ProteomesiUP000002593: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 578578Glutamate--tRNA ligasePRO_0000367801Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi415426.Hbut_0542.

    Structurei

    3D structure databases

    ProteinModelPortaliA2BK91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi97 – 10711"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000073585.
    KOiK01885.
    OMAiAFRIIDT.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    2.40.240.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2BK91-1 [UniParc]FASTAAdd to Basket

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    MLNAVGHGGR AAVGPVMGKI MAERPDLRPQ AKQIVAIVRE VVEEVNKLSL    50
    EEQKRLLEEK YSWVIEKKLQ KRREAVEKKL PPLPDAEEGR VVTRFAPNPD 100
    FVIHLGNARP ALLSYEYAVM YRGKMILRFE DTDPRIKTPL PEAYELIRED 150
    LKWLGIRWDE EYIQSLRMHI YYDIARKLIE VGGAYVDDRS PEEFRRYRDE 200
    GRLEDYPPRK RSVEENLELW DKMVSGAFGE GEAVLRVKTD PRHPDPSVRD 250
    WVAFRIIDTS RYPHPLVGDR YVAWPTYNFA AAVDDKLMGV THILRAKEHM 300
    QNTIKQQFLY KHLGWSYPHV VHFGRLKLEG FIMSKSTLKR FLDAGISRGI 350
    DDPRFATIAG LRRRGIVPEA IKKLIMEVGV KYTDASISYD NLAAINRSII 400
    DPRAKRIMAA LSPVPVEVEG LPWREKEFRI PFHPSGQLGE RIVKLAGPKA 450
    TIYVSQSDAV QLAKGNIVRL MEAFNIEVLG ASPRRVRARY HSLTVDEARQ 500
    HNAPIIQWVP ATDNIAVEVL KPEGLDLVQE RGLAEPAAAQ LKPGEIIQLV 550
    RIGFARVDSV ETDEKGKVRK VVLIYAHD 578
    Length:578
    Mass (Da):66,009
    Last modified:February 20, 2007 - v1
    Checksum:iAB7854019C4E9E29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000493 Genomic DNA. Translation: ABM80402.1.
    RefSeqiYP_001012747.1. NC_008818.1.

    Genome annotation databases

    EnsemblBacteriaiABM80402; ABM80402; Hbut_0542.
    GeneIDi4782144.
    KEGGihbu:Hbut_0542.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000493 Genomic DNA. Translation: ABM80402.1 .
    RefSeqi YP_001012747.1. NC_008818.1.

    3D structure databases

    ProteinModelPortali A2BK91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 415426.Hbut_0542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM80402 ; ABM80402 ; Hbut_0542 .
    GeneIDi 4782144.
    KEGGi hbu:Hbut_0542.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000073585.
    KOi K01885.
    OMAi AFRIIDT.

    Enzyme and pathway databases

    BioCyci HBUT415426:GC56-542-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    2.40.240.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C."
      Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M., She Q., Garrett R.A., Klenk H.-P.
      Archaea 2:127-135(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 5456 / JCM 9403.

    Entry informationi

    Entry nameiSYE_HYPBU
    AccessioniPrimary (citable) accession number: A2BK91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3