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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Hbut_0542
OrganismiHyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)
Taxonomic identifieri415426 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaeHyperthermus
Proteomesi
  • UP000002593 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003678011 – 578Glutamate--tRNA ligaseAdd BLAST578

Interactioni

Protein-protein interaction databases

STRINGi415426.Hbut_0542.

Structurei

3D structure databases

ProteinModelPortaliA2BK91.
SMRiA2BK91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi97 – 107"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04302. Archaea.
COG0008. LUCA.
HOGENOMiHOG000073585.
KOiK01885.
OMAiMRFAPNP.
OrthoDBiPOG093Z013J.

Family and domain databases

Gene3Di2.40.240.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_02076. Glu_tRNA_synth_type2. 1 hit.
InterProiView protein in InterPro
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_N.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A2BK91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNAVGHGGR AAVGPVMGKI MAERPDLRPQ AKQIVAIVRE VVEEVNKLSL
60 70 80 90 100
EEQKRLLEEK YSWVIEKKLQ KRREAVEKKL PPLPDAEEGR VVTRFAPNPD
110 120 130 140 150
FVIHLGNARP ALLSYEYAVM YRGKMILRFE DTDPRIKTPL PEAYELIRED
160 170 180 190 200
LKWLGIRWDE EYIQSLRMHI YYDIARKLIE VGGAYVDDRS PEEFRRYRDE
210 220 230 240 250
GRLEDYPPRK RSVEENLELW DKMVSGAFGE GEAVLRVKTD PRHPDPSVRD
260 270 280 290 300
WVAFRIIDTS RYPHPLVGDR YVAWPTYNFA AAVDDKLMGV THILRAKEHM
310 320 330 340 350
QNTIKQQFLY KHLGWSYPHV VHFGRLKLEG FIMSKSTLKR FLDAGISRGI
360 370 380 390 400
DDPRFATIAG LRRRGIVPEA IKKLIMEVGV KYTDASISYD NLAAINRSII
410 420 430 440 450
DPRAKRIMAA LSPVPVEVEG LPWREKEFRI PFHPSGQLGE RIVKLAGPKA
460 470 480 490 500
TIYVSQSDAV QLAKGNIVRL MEAFNIEVLG ASPRRVRARY HSLTVDEARQ
510 520 530 540 550
HNAPIIQWVP ATDNIAVEVL KPEGLDLVQE RGLAEPAAAQ LKPGEIIQLV
560 570
RIGFARVDSV ETDEKGKVRK VVLIYAHD
Length:578
Mass (Da):66,009
Last modified:February 20, 2007 - v1
Checksum:iAB7854019C4E9E29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000493 Genomic DNA. Translation: ABM80402.1.

Genome annotation databases

EnsemblBacteriaiABM80402; ABM80402; Hbut_0542.
KEGGihbu:Hbut_0542.

Similar proteinsi

Entry informationi

Entry nameiSYE_HYPBU
AccessioniPrimary (citable) accession number: A2BK91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 20, 2007
Last modified: February 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome