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Protein

Fructose-1,6-bisphosphate aldolase/phosphatase

Gene

fbp

Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).UniRule annotation

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.UniRule annotation
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei15Proton acceptor; for FBP phosphatase activityUniRule annotation1
Metal bindingi15Magnesium 1UniRule annotation1
Metal bindingi22Magnesium 1; via pros nitrogenUniRule annotation1
Binding sitei22FBP; via tele nitrogenUniRule annotation1
Metal bindingi56Magnesium 1UniRule annotation1
Metal bindingi56Magnesium 2UniRule annotation1
Metal bindingi57Magnesium 2UniRule annotation1
Binding sitei94FBPUniRule annotation1
Metal bindingi98Magnesium 1UniRule annotation1
Metal bindingi135Magnesium 2UniRule annotation1
Binding sitei136FBP/DHAPUniRule annotation1
Active sitei232Proton donor/acceptor; for FBP aldolase activityUniRule annotation1
Active sitei235Schiff-base intermediate with DHAP; for FBP aldolase activityUniRule annotation1
Metal bindingi235Magnesium 3; via carbonyl oxygenUniRule annotation1
Metal bindingi236Magnesium 3UniRule annotation1
Metal bindingi236Magnesium 4UniRule annotation1
Metal bindingi237Magnesium 2UniRule annotation1
Metal bindingi237Magnesium 3UniRule annotation1
Binding sitei269FBP/DHAP; via amide nitrogenUniRule annotation1
Binding sitei290FBP/DHAPUniRule annotation1
Binding sitei351FBPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation, LyaseUniRule annotation
Biological processCarbohydrate metabolismUniRule annotation, GluconeogenesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation, Schiff baseUniRule annotation

Enzyme and pathway databases

BioCyciHBUT415426:GC56-487-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphate aldolase/phosphataseUniRule annotation (EC:3.1.3.11UniRule annotation, EC:4.1.2.13UniRule annotation)
Short name:
FBP A/PUniRule annotation
Short name:
FBP aldolase/phosphataseUniRule annotation
Gene namesi
Name:fbpUniRule annotation
Ordered Locus Names:Hbut_0487Imported
OrganismiHyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)Imported
Taxonomic identifieri415426 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaeHyperthermus
Proteomesi
  • UP000002593 Componenti: Chromosome

Interactioni

Subunit structurei

Homooctamer; dimer of tetramers.UniRule annotation

Protein-protein interaction databases

STRINGi415426.Hbut_0487.

Structurei

3D structure databases

ProteinModelPortaliA2BK38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 108FBP bindingUniRule annotation2
Regioni245 – 246FBP binding; shared with dimeric partnerUniRule annotation2

Domaini

Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.UniRule annotation

Sequence similaritiesi

Belongs to the FBP aldolase/phosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04180. Archaea.
COG1980. LUCA.
HOGENOMiHOG000229394.
KOiK01622.
OMAiHLVAGWM.
OrthoDBiPOG093Z0396.

Family and domain databases

HAMAPiMF_02067. FBP_aldolase_phosphatase. 1 hit.
InterProiView protein in InterPro
IPR002803. FBPase_V.
PfamiView protein in Pfam
PF01950. FBPase_3. 1 hit.
PIRSFiPIRSF015647. FBPtase_archl. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014260. FBPase_V. 1 hit.
SUPFAMiSSF111249. SSF111249. 1 hit.

Sequencei

Sequence statusi: Complete.

A2BK38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEERRVTIS VIKADIGSIA GHHKVHPDTI AAATRVLAEA KRKGTIIDFY
60 70 80 90 100
VTHVGDDLQL IMTHRKGVDS PEIHGLAWEA FKKAAEVAKE LGLYAAGQDL
110 120 130 140 150
LSDAFSGNVR GLGPGVAEME FVERPSEPIV VFMADKTEPG AFNLPLYRIF
160 170 180 190 200
ADPFNTAGLV IDPRMHDGFK FEVLDVLEGK YVVLNAPEEL YDLLALIGTP
210 220 230 240 250
SRYVIKRIYR KRDNEIAAVV SVERLNLIAG RYVGKDDPVA IVRAQSGFPA
260 270 280 290 300
VGEILEPFSF PHLVAGWMRG SHWGPLMPVS LRDAKCTRFD GPPRIVALGF
310 320 330 340 350
QVTKGKLIGP VDLFDDPAFD EARRLAQQIA DYMRRHGPFM PHRLGPEEME
360 370 380 390
YTTLPQVLEK LKNRFAEAKD YEKYIKPKIK KSELLTGEET HD
Length:392
Mass (Da):43,696
Last modified:February 20, 2007 - v1
Checksum:i9C00243E10504A9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000493 Genomic DNA. Translation: ABM80349.1.
RefSeqiWP_011821667.1. NC_008818.1.

Genome annotation databases

EnsemblBacteriaiABM80349; ABM80349; Hbut_0487.
GeneIDi4781725.
KEGGihbu:Hbut_0487.

Similar proteinsi

Entry informationi

Entry nameiA2BK38_HYPBU
AccessioniPrimary (citable) accession number: A2BK38
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 27, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported